Dowling-Degos Disease

Watchlist

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Retrieved

2021-01-23

Source

Orphanet

Trials

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Genes

KRT5, POFUT1, POGLUT1, PSENEN, ADAM10, CFH, IL1B, TYRP1, ACAN, CFHR5, TNF, TRP-AGG2-6, RANBP2, DCT, TBPL1, TRPV1, SHBG, LZTR1, TRPC6, SIRT1, TRPC3, TRP-TGG3-1, SMC1A, SYNGAP1, TGFBR2, TGFB1, TAC1, SPTBN2, FTO, OPA1, SET, EGF, ANG, SERPINA6, COL9A2, COL9A3, COMT, CSF1, CCN2, CTNNB1, DDT, EGR3, PTH1R, HNRNPA1, IGF1, IL4, IL5, IL6, CXCL8, LEP, LTA, NFKB1, DDTL

Drugs

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A rare, genetic, hyperpigmentation of the skin disease characterized by adulthood-onset of reticular, reddish-brown to dark-brown, macular and/or comedone-like, hyperkeratotic papules with hypopigmented macules, predominantly affecting flexural areas and, on occasion, progressing to involve trunk and acral regions. Histologically, epidermal acanthosis, thin, branch-like, rete ridges, and a tendency for acantholysis and pigmentary incontinence is observed.