Shiga Toxin-Associated Hemolytic Uremic Syndrome

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Retrieved

2021-01-23

Source

Orphanet

Trials

—

Genes

STX2, PROC, TFPI

Drugs

Eculizumab ( SOLIRIS ), equine immunoglobulin F(ab')2 fragments targeting Shiga toxin

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Typical hemolytic-uremic syndrome (typical HUS) is a thrombotic microangiopathy characterized by mechanical hemolytic anemia, thrombocytopenia, and renal dysfunction that is usually associated with prodromal enteritis caused by Shigella dysentriae type 1 or E. Coli.