Renal Tubular Acidosis Iii

Morris et al. (1969) observed 2 unrelated infant girls with a distinct form of bicarbonate-wasting RTA, which they referred to as dislocation type. Huth et al. (1960) separated the group with onset in infancy and childhood from that with onset in later life. The former seems to be a genetic disorder transmitted as an autosomal recessive, although a predominance of males has been observed. Wilson et al. (1967) studied 2 families, each with a case of late-onset renal tubular acidosis, and found elevation of serum immunoglobulins in close relatives but no other cases of renal tubular acidosis. Renal tubular acidosis becomes apparent because of: periodic paralysis due to hypokalemia; rickets or osteomalacia; kidney stones; or nephrocalcinosis by abdominal x-ray.