Distichiasis With Congenital Anomalies Of The Heart And Peripheral Vasculature

In a mother and her 4 children, Goldstein et al. (1985) described a previously unreported syndrome of distichiasis with congenital heart defects and mixed peripheral vascular anomalies. The 52-year-old mother had ventricular septal defect. Two daughters had surgery for patent ductus arteriosus (see 607411). Sinus bradycardia alone (elder son), with stress-induced asystole (younger son), and with wandering atrial pacemaker (both daughters) were documented electrocardiographically. Of the 5, 3 had edema, 2 had visible varicosities, 3 had symptoms of chronic venous disease of the legs, and the older daughter, aged 19, had complaints suggesting arterial disease in the legs.