Prostate Cancer, Hereditary, 7
For a general discussion of hereditary prostate cancer, see 176807.
MappingLange et al. (2006) performed a genomewide linkage scan on 71 informative families with 2 or more men with aggressive prostate cancer. When only men with aggressive prostate cancer were coded as affected, statistically significant evidence for linkage at chromosome 15q12 was detected, with a lod score of 3.49 (genomewide p = 0.005). The evidence for linkage increased when analyses were restricted to 65 Caucasian American pedigrees (lod score, 4.05) or to 42 pedigrees with 2 confirmed aggressive cases (lod score, 4.76). No significant linkage was found to either 7q32 or 19q12, two quantitative trait loci that have been associated with prostate cancer aggressiveness (see 607592).
FitzGerald et al. (2010) performed genomewide SNP linkage analysis of 96 families with hereditary prostate cancer, each of which had 1 or more first-degree relatives with colon cancer. The strongest linkage signal was identified at chromosome 15q14 for a 31.04-cM interval spanning rs732165 and rs1989223, when both prostate and colon cancer phenotypes were considered to be affected in families with 2 or more colon cancer cases (recessive HLOD = 3.88).