Polyposis, Gastric
Clinical Features
Dos Santos and de Magalhaes (1980) described a family in which 10 members of 3 generations had multiple polyposis, with adenocarcinomatous propensities, limited to the stomach. No male-to-male transmission was observed. Seruca et al. (1991) restudied the family reported by dos Santos and de Magalhaes (1980) and added an observation of male-to-male transmission. Contrary to the original description, the histology of the gastric polyps present in the affected members revealed hyperplastic features and no adenomatous changes. Severe psoriasis was present in some members of the family as a probable coincidental disorder.
InheritanceBased on the observation of male-to-male transmission of gastric polyposis in the family originally reported by Dos Santos and de Magalhaes (1980), Seruca et al. (1991) suggested autosomal dominant inheritance.