Leiomyosarcoma

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Retrieved

2022-04-26

Source

Gard

Trials

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Genes

USP18, HMGA1, PTGS2, CSF3, DMD, CHEK2, MED12, TP53, KIT, CDKN2A, MDM2, IGF2, BCL2, TP63, PIK3CA, MYC, H3P10, PIK3CB, PIK3CD, PTEN, FH, ESR1, CD274, PIK3CG, ALK, VCAN, MYOCD, HMGA2, CALD1, HHAT

USP18, HMGA1, PTGS2, CSF3, DMD, CHEK2, MED12, TP53, KIT, CDKN2A, MDM2, IGF2, BCL2, TP63, PIK3CA, MYC, H3P10, PIK3CB, PIK3CD, PTEN, FH, ESR1, CD274, PIK3CG, ALK, VCAN, MYOCD, HMGA2, CALD1, HHAT, AKT1, SERPINE1, HTC2, BRCA1, IGF1, ATM, HDAC9, CDH1, CD163, PGR, ABCB1, SMUG1, RRAS2, PRUNE2, ACTB, AXL, VIM, CTNNB1, ZEB1, MIR200C, TYRO3, DFFB, SNAI2, DES, TOPBP1, NDC80, VDR, FERMT2, RASSF1, EDIL3, TP73, AGTR2, AGTR1, TP53BP1, TPX2, ARL4C, IFITM1, VEGFA, IRS2, MVP, DLEC1, ZEB2, VIPR2, CCDC6, KLF4, SLC33A1, COIL, LATS1, SOCS3, SLC25A11, PEG10, PDCD4, TBC1D9, RFTN1, NACC1, AZIN2, RICTOR, CHAMP1, GADL1, RTL1, MIR10A, MIR125A, MIR152, MIR21, MIR221, MIR34C, MIR93, GGTLC5P, SSX2B, GGTLC3, GGT2, GGTLC4P, PGR-AS1, WDR20, MYLK3, MYLK2, BCOR, ZNF281, LMOD1, TOP2A, PARP1, LEF1, UBASH3A, MOV10L1, FBLIM1, ANO1, TRIM63, RCBTB1, SMARCAD1, PNPLA2, WDR48, PRUNE1, ZNF250, FERMT3, OBSCN, AMHR2, CDO1, TNS1, GAS6, F3, ACSL4, FASN, FCGR3A, FCGR3B, FGF2, FOLH1, FUS, GGT1, CDH2, GLI1, GRN, HIF1A, CD68, HMMR, HSP90AA1, CD34, IL1R1, EWSR1, ERCC5, TERT, DDIT3, CHGA, COL1A1, CR2, CSF1, CDK8, NKX2-5, DAP, DCC, DFFA, EPHB2, DHCR24, CDK4, DPEP1, E2F1, EGF, EGFR, ELN, SLC29A1, CXCL8, INSRR, ITGA7, TSPAN31, BGN, BCL6, ACVRL1, PLAG1, PLAU, MAPK1, APEX1, RB1, SCN1A, JAK1, SETMAR, SLPI, CETN1, SP3, SRC, SRF, SSX2, STAT3, PECAM1, PDGFRB, PDGFRA, PDGFB, CCK, KRAS, LGALS3, MBD1, MEF2A, MEF2D, MET, MMP2, MRC1, GADD45B, MYLK, PPP1R12A, NME1, NPAS2, NTRK1, ROR2, PCP4, SMARCB1

Drugs

(-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1yl)-4-(1H-indol-3-yl) pyrrolidine-2, 5-dione, (1-methyl-2-nitro-1H-imidazole-5-yl)methyl N,N'-bis(2-bromoethyl) diamidophosphate, 16-base single-stranded peptide nucleic acid oligonucleotide linked to a 7-amino acid peptide, 18-(p-(, 4-oxo-4H-chromene-2-carboxylic acid (2-(2-4-(2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl)-phenyl-2H-tetrazol-5-yl)-4,5-dimethoxy-phenyl)-amide, 7-ethyl-10-hydroxy-camptothecin, Anlotinib, Autologous CD4+ and CD8+ T cells transduced with a lentiviral vector encoding an affinity enhanced T cell receptor specific to MAGE-A4, Autologous CD4+ and CD8+ T cells transduced with lentiviral vector containing an affinity-enhanced T-cell receptor targeting the New York esophageal antigen-1, Brostallicin, Camsirubicin, Crenolanib besylate, Deforolimus, Doxorubicin hydrochloride (liposomal) ( DOXIL ), Doxorubicin(6-maleimidocaproyl)hydrazone, Fenretinide, Fibromun, Genetically modified serotype 5/3 adenovirus coding for granulocyte-macrophage colony-stimulating factor, Human/murine chimeric monoclonal antibody against endoglin, Larotrectinib ( VITRAKVI ), Mammalian target of rapamcyin (mTOR) inhibitor, N-acetylsarcosyl-glycyl-L-valyl-D-allo-isoleucyl-L-threonyl-L-norvalyl-L-isoleucyl-L-arginyl-L-prolyl-N-ethylamide, Olaratumab ( LARTRUVO ), Ombrabulin, Paclitaxel ( TAXOL ), Palifosfamide, Propranolol hydrochloride ( HEMANGEOL ), Sindbis virus envelope pseudotyped lentiviral vector encoding New York oesophageal squamous cell carcinoma-1 protein, Trabectedin ( YONDELIS ), Vinorelbine tartrate, Yttrium (90Y)-DTPA-radiolabelled chimeric monoclonal antibody against frizzled homologue 10

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Leiomyosarcoma is a rare cancerous tumor that consists of smooth (involuntary) muscle cells. Leiomyosarcoma is a type of sarcoma. It spreads through the blood stream and can affect the lungs, liver, blood vessels, or any other soft tissue in the body. The exact cause of leiomyosarcoma is not known, although genetic and environmental factors appear to be involved. It is most often found in the uterus or abdomen.