Adult T-Cell Leukemia/lymphoma
Watchlist
Retrieved
2022-04-26
Source
Trials
—
Genes
IRF4,
IL2,
CCR4,
FOXP3,
IFNA1,
IL10,
IL4,
STAT3,
TERF2,
TLX1,
IFNG,
BIRC5,
FYN,
PRKCB,
PLCG1,
BMP6,
IKZF2,
GATA3,
CTLA4,
CARD11,
VAV1,
HNRNPA2B1,
CCR7,
CSNK1A1,
CSNK2A1,
CSNK2B,
IFNA2,
TP73,
GPR183,
CD28
IRF4,
IL2,
CCR4,
FOXP3,
IFNA1,
IL10,
IL4,
STAT3,
TERF2,
TLX1,
IFNG,
BIRC5,
FYN,
PRKCB,
PLCG1,
BMP6,
IKZF2,
GATA3,
CTLA4,
CARD11,
VAV1,
HNRNPA2B1,
CCR7,
CSNK1A1,
CSNK2A1,
CSNK2B,
IFNA2,
TP73,
GPR183,
CD28,
ICOS,
CD86,
CD80,
TRBV20OR9-2,
CNTN2,
PTHLH,
HBZ,
ERVK-32,
THBS1,
ATF7IP,
TP53,
CDKN2A,
ISG20,
IL2RA,
CADM1,
TAL1,
NOTCH1,
ERVK-20,
ERVW-1,
FAS,
ICAM1,
ATN1,
H3P10,
SERPINH1,
CD274,
TXN,
ERVK-6,
TNFRSF8,
ERVK-18,
F9,
HLA-A,
H3P13,
BCL2,
CDKN2D,
REG1A,
IL23A,
TCL1A,
TCL1B,
APRT,
MFAP1,
IL1B,
CREBBP,
STAT1,
EZH2,
CDKN2B,
TGFB1,
IFNA13,
IL6,
IL1A,
BCL11B,
GORASP1,
WNK1,
JUN,
JUND,
IL15,
FOS,
CDKN1A,
MVP,
SOAT1,
RELA,
SYT1,
PTH,
PTPA,
PIK3CG,
NDRG2,
PIK3CD,
PIK3CB,
PIK3CA,
CREB1,
MYC,
GZMM,
H3P9,
HSP90AA1,
LCK,
IL13,
NXT1,
TPPP,
SUB1,
ITGAL,
ITGB2,
JAK3,
MRPL28,
MCL1,
TNFSF10,
MSH3,
MYB,
TNFSF11,
VCAM1,
TNF,
PTEN,
RAD51,
CDKN1B,
B2M,
CDK2,
FOSL2,
AKT1,
TRBV16,
TRBV7-9,
TRBC1,
CD40LG,
PTPRA,
KRT20,
CD58,
PSMD10,
S100A4,
PSMD9,
TMED5,
TMED7,
SCLY,
SAI1,
RHOA,
ATM,
FUT4,
CCL3,
MTAP,
MDM2,
MET,
POLD4,
AICDA,
MMP9,
MSH2,
CRP,
POLE4,
CD52,
NCAM1,
NFKB1,
NOS1,
NOS2,
FBXW7,
ABCB1,
TET2,
SIRT1,
CCL22,
LRP1,
SELL,
TNFRSF4,
PRMT5,
CASP3,
PATJ,
BCAP31,
XPO1,
DNALI1,
TOX,
CDR3,
GOSR1,
SOCS1,
TBPL1,
GSTO1,
NOG,
TNFRSF10A,
MAGI1,
CFLAR,
CAT,
CIB1,
ZNRD2,
STAT5B,
CCND1,
SMARCA4,
CHP1,
TMED2,
CD34,
DCTN6,
STAT5A,
SYK,
BCR,
MS4A1,
CD9,
TAL2,
TARS1,
ZEB1,
TRB,
TERT,
CTAG1B,
PDCD1,
LOXL2,
RPSA,
JUNB,
DPP4,
NRSN1,
CNKSR3,
IL9,
CTAG1A,
IL27,
TICAM2,
ETS1,
IFI27,
TMED7-TICAM2,
FCGRT,
HRES1,
HLA-DRB1,
HLA-B,
FOSB,
HGF,
MSH6,
CCR10,
H3P23,
H3P24,
H3P19,
H3P5,
KRT7,
IFNL3,
ALK,
CTNNB1,
ATL2,
LMO2,
LORICRIN,
LGALS9,
NOX5,
LBX1,
CTCF,
MIR1193,
CXCR6,
TXNIP,
CDKN2B-AS1,
PDLIM5,
MIR3662,
AHSA1,
XIAP,
BATF,
RPL17-C18orf32,
RTN4,
POTEF,
AZI2,
H3P37,
JPX,
PIM3,
MIR31,
MIR28,
CCR9,
CCL27,
BCL6,
MIR212,
DSTN,
BCL2L1,
MAP4K5,
AKAP13,
ATG7,
STAMBPL1,
KAT5,
SPATA2,
LPAR2,
PRDM16,
APOBEC3G,
UBL5,
GRAP2,
IL21,
ADRA1A,
ADRA2B,
LOC110283621,
BUB1,
HERPUD1,
SART3,
AGRP,
SUPT7L,
MIR150,
RN7SL263P,
BRS3,
KMT2C,
NAMPT,
PDLIM2,
GPHN,
DLEU1,
SUGP1,
PIAS3,
LOC102724334,
JAG1,
AHR,
CFDP1,
MIR155,
MIR146A,
PBK,
GEMIN4,
ASZ1,
RBM45,
ATF3,
SLC12A9,
NLRP3,
ATL1,
POLK,
NCKIPSD,
IL17F,
FOXP2,
PWWP3A,
H2BS1,
ZDHHC16,
ASCC2,
TMED9,
USP44,
PLVAP,
TM9SF3,
AHI1,
ARTN,
FEZF2,
URM1,
THUMPD1,
FASLG,
TDP1,
PAG1,
EPC1,
HDAC8,
NSFL1C,
SPOCK3,
ACKR3,
MIR145,
IL21R,
MIR126,
SACM1L,
TPX2,
TBC1D9,
MIR106A,
DICER1,
TBPL2,
SLC44A1,
BAX,
RNF19A,
TIGAR,
POT1,
APC,
ATL3,
POLDIP2,
IFT172,
PTPN22,
TINF2,
LAT,
PCBP4,
SND1,
ANK1,
AMFR,
NRK,
BAK1,
BAD,
CENPV,
TLX3,
CADM4,
CLDN10,
CCNB1,
BCL10,
LBR,
SMAD3,
LTA,
LMO1,
LIF,
LGALS3,
LGALS1,
LCT,
LCN2,
KIT,
MAS1,
CUX1,
CX3CR1,
CYP1A1,
JAK1,
ITGB7,
DDIT3,
ITGB1,
ITGAX,
SMAD7,
ADAM11,
DNTT,
MTTP,
NRF1,
CISH,
CNOT3,
NFKB2,
NFE2L1,
ATF2,
CRK,
MUC1,
MTHFR,
MDM4,
ABCC1,
MRC1,
MMP7,
MMP2,
KMT2A,
MLH1,
MIP,
MAPK14,
DLG1,
IRF3,
CDK5R1,
FN1,
EPOR,
FCGR3A,
IRF8,
FCGR3B,
FOXN2,
HSF1,
TLX2,
FKBP4,
HAL,
EP300,
MTOR,
GSTM1,
GSN,
GPR42,
GLP1R,
GFI1,
GDNF,
GBP2,
IFNB1,
IGH,
ING1,
EGFR,
IL17A,
IL16,
E2F4,
EDNRA,
EGF,
CXCL8,
IL7,
IL6R,
IL5,
IKBKB,
EGR1,
IL3,
IL2RG,
IL2RB,
EIF4E,
EIF4G2,
ELAVL2,
ENO2,
OAS3,
TNFRSF11B,
PCNA,
TRG,
TNFRSF1A,
GATA4,
TMSB4X,
CCND3,
CD3D,
TFRC,
CD3G,
TERF1,
CD247,
CAV1,
CD5,
CD27,
SSTR4,
SRPK1,
SPTAN1,
SOX4,
CD38,
FSCN1,
TNFRSF1B,
CASP8,
PDE4A,
CA9,
NRP1,
TNFRSF10B,
TNFRSF6B,
ADAM21,
BUB1B,
TP63,
TSPO,
ZNF282,
AIMP2,
TYR,
DEK,
CXCR4,
ZAP70,
WNT5A,
VIM,
VEGFA,
VCP,
CASP2,
SNCA,
SNAP25,
SMARCB1,
MAPK1,
ACTB,
RAB4A,
PTPN13,
PTPN6,
CD68,
CD69,
PSMD2,
MAP2K7,
CD70,
PMEL,
CD151,
PMS1,
PLEK,
PLAU,
PIN1,
CDK9,
PIM1,
CES1,
RAF1,
RBL2,
RBP4,
OPN1LW,
CCL21,
CCL20,
CCL18,
CCL2,
CCL1,
SCT,
CLEC11A,
SATB1,
S100B,
S100A1,
RPL17,
RORC,
RNASE3,
RGS1,
RENBP,
CD44,
REL,
ABL1
Drugs
A lentiviral vector pseudotyped by the Indiana serotype of the vesicular stomatitis virus G protein encoding an antigen derived from the Tax, HBZ, p12I and p30II HTLV-1 proteins,
A lentiviral vector pseudotyped by the New-Jersey serotype of the vesicular stomatitis virus G protein encoding an antigen derived from the Tax, HBZ, p12I and p30II HTLV-1 proteins,
A-dmDT390-bisFv(UCHT1)
A lentiviral vector pseudotyped by the Indiana serotype of the vesicular stomatitis virus G protein encoding an antigen derived from the Tax, HBZ, p12I and p30II HTLV-1 proteins,
A lentiviral vector pseudotyped by the New-Jersey serotype of the vesicular stomatitis virus G protein encoding an antigen derived from the Tax, HBZ, p12I and p30II HTLV-1 proteins,
A-dmDT390-bisFv(UCHT1),
Adenovirus-Interferon gamma - coding DNA sequence,
Alisertib,
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus,
Belinostat
(
BELEODAQ
),
Brentuximab vedotin
(
ADCETRIS
),
Chlormethine
(
Ledaga
),
Darinaparsin,
Denileukin diftitox,
Fenretinide,
Forodesine hydrochloride,
Human monoclonal antibody against CD4,
Humanised IgG1 monoclonal antibody against human KIR3DL2,
Iodine (131I) tositumomab,
Miltefosine
(
IMPAVIDO
),
Mogamulizumab
(
POTELIGEO
),
N-(2-aminophenyl)-4-(1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]piperidin)benzamide,
Naloxone hydrochloride dihydrate,
Panobinostat
(
FARYDAK
),
Pralatrexate
(
FOLOTYN
),
Recombinant anti-CD3-bi-single-chain-Fv-diphtheria toxin fusion protein,
Resiquimod,
Romidepsin
(
ISTODAX
),
Sintilimab,
Siplizumab,
Suberolylanilide hydroxamic acid,
Synthetic hypericin,
Vorinostat
(
ZOLINZA
),
Zanolimumab,
haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate
Registered!
Adult T-cell leukemia/lymphoma (ATL) is is a rare and aggressive T-cell lymphoma that is linked to infection by the human T-cell lymphotropic virus 1 (HTLV-1). The exact mechanism by which HTLV-I infection causes the ATL is unknown. The clinical features of ATL include generalized swelling of the lymph nodes (lymphadenopathy), increased liver and spleen size (hepatosplenomegaly), immunosuppression, high levels of calcium in the blood, lytic bone lesions (spots that appear as “holes” on a standard bone x-ray), and skin lesions. There are four basic clinical variants of ATL: acute (60% of cases), lymphomatous (20 % of cases), chronic (10% of cases) and smoldering (10% of cases). The best treatment for these patients is unclear and patients should be enrolled in clinical trials whenever possible. Medication may include CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisone) or EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide and prednisone). In some patients, a bone marrow transplant may be recommended.