Photodermatitis

Photodermatitis, sometimes referred to as sun poisoning or photoallergy, is a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. It is distinct from sunburn.

Signs and symptoms

Photodermatitis may result in swelling, difficulty breathing, a burning sensation, a red itchy rash sometimes resembling small blisters, and peeling of the skin. Nausea may also occur. There may also be blotches where the itching may persist for long periods of time. In these areas an unsightly orange to brown tint may form, usually near or on the face.

Causes

Many medications and conditions can cause sun sensitivity, including:

• Sulfa used in some drugs, among them some antibiotics, diuretics, COX-2 inhibitors, and diabetes drugs.
• Psoralens, coal tars, photo-active dyes (eosin, acridine orange)
• Musk ambrette, methylcoumarin, lemon oil (may be present in fragrances)
• PABA (found in sunscreens)
• Oxybenzone (UVA and UVB chemical blocker also in sunscreens)
• Salicylanilide (found in industrial cleaners)
• St John's Wort
• Hexachlorophene (found in some prescription antibacterial soaps)
• Tetracycline antibiotics (e.g., tetracycline, doxycycline, minocycline)
• Benzoyl peroxide
• Retinoids (e.g., isotretinoin)
• Some NSAIDs (e.g., ibuprofen, naproxen sodium)
• Fluoroquinolone antibiotic: Sparfloxacin in 2% of cases
• Amiodarone, used to treat atrial fibrillation
• Pellagra

Photodermatitis can also be caused by plants such as Ammi majus, parsnip, giant hogweed (Heracleum mantegazzianum), common rue (Ruta graveolens), and Dictamnus, a genus of flowering plants in the family Rutaceae with a single species Dictamnus albus, commonly called the burning bush. Photodermatitis caused by plants is called phytophotodermatitis.

Prevention

Prevention includes avoiding exposure to chemicals that can trigger the reaction, such as by wearing gloves, or avoiding sunlight or wearing sunscreen preferably with at least factor 30 and with a high UVA protection level on the affected area.

See also

• Photosensitivity
• Solar urticaria