Foreign Body Granuloma

The foreign body granuloma is a response of biological tissue to any foreign material in the tissue. Tissue-encapsulation of an implant is an example, as is inflammation around a splinter.

The presence of the implant changes the healing response, and this is called the foreign-body reaction (FBR). FBR consists of: protein adsorption, macrophages, multinucleated foreign body giant cells (macrophage fusion), fibroblasts, and angiogenesis. It has also been proposed that the mechanical property of the interface between an implant and its surrounding tissues is critical for the host response.

Gallery

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  A foreign-body response to talc (talcosis) due to intravenous drug use. H&E stain.

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  Foreign body giant cell reaction to nylon suture material

See also

• Foreign body
• List of cutaneous conditions