Hand-Foot-Genital Syndrome Watchlist (log in to enable) Retrieved 2021-01-23 Source Orphanet Trials — Genes HOXA13, HOTTIP, HOXD13, HOXA@ Drugs — Interested in hearing about new therapies? Registered! Hand-foot-genital syndrome (HFGS) is a very rare multiple congenital abnormality syndrome characterized by distal limb malformations and urogenital defects.