Birdshot Chorioretinopathy

Watchlist

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Retrieved

2022-04-26

Source

Gard

Trials

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Genes

HLA-A, LNPEP, TECPR2, ERAP2, GEM, KIR3DL1, HLA-C, HLA-DQA1, IFNG, IL17A, KIR2DL2, POU2F1, SLC22A1, ERAP1, KIR2DS2

Drugs

3-{[2,3,5,6-tetrafluoro-3'-(trifluoromethoxy)biphenyl-4-yl]carbamoyl}thiophene-2-carboxylic acid, 4-((E)-(5-(2-(2-((S)-2-((S)-1-(L-threonyl-L-lysyl)pyrrolidine-2-carboxamido)-5-guanidinopentanamido)acetamido)-2-carboxyethyl)-2-hydroxyphenyl)diazenyl)phenyl (2-(trimethylammonio)ethyl) phosphate, Adalimumab ( CYLTEZO, AMGEVITA, AMSPARITY, HALIMATOZ, HEFIYA, HULIO, HUMIRA, HYRIMOZ, KROMEYA, IDACIO, IMRALDI ), Autologous collagen type II-specific regulatory T cells, Cyclo {{(E,Z)-(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)nona-6,8-dienoyl}-L-2-aminobutyryl-N-methyl-glycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-Dalanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl}, Dexamethasone (intravitreal implant) ( OZURDEX ), Fluocinolone ( RETISERT ), Fluocinolone acetonide (prolonged-release intravitreal implant), Gevokizumab, HLA-B27 derived peptide (amino acid 125-138), Voclosporin

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Birdshot chorioretinopathy is an eye condition in which painless, light-colored spots develop on the retina. These spots are scattered in a "birdshot" pattern. The effects of this condition on vision are quite variable; some individuals' vision is only mildly affected, whereas others experience a significant decline in vision, the appearance of floaters (small specks that appear in one's line of sight), night blindness, and other vision problems. Symptoms typically begin around middle age; Caucasians are affected more than individuals of other ethnicities. The cause of birdshot chorioretinopathy is currently unknown, but it is suspected to be an autoimmune disease. Treatment may include medications that aim to regulate the body's immune response.