Merkel Cell Carcinoma
Watchlist
Retrieved
2022-04-26
Source
Trials
—
Genes
MYC,
SDHD,
CD274,
TP53,
KRT20,
KIT,
PDCD1,
C17orf97,
CDKN2A,
PIK3CA,
PIK3CG,
PIK3CD,
PIK3CB,
PDGFRA,
TP63,
ALK,
BCL2,
MIR375,
ATOH1,
INSM1,
SST,
EZH2,
SMUG1,
RB1,
RPE65,
NCAM1,
PAX5,
SATB2,
CTLA4,
ASCL1
MYC,
SDHD,
CD274,
TP53,
KRT20,
KIT,
PDCD1,
C17orf97,
CDKN2A,
PIK3CA,
PIK3CG,
PIK3CD,
PIK3CB,
PDGFRA,
TP63,
ALK,
BCL2,
MIR375,
ATOH1,
INSM1,
SST,
EZH2,
SMUG1,
RB1,
RPE65,
NCAM1,
PAX5,
SATB2,
CTLA4,
ASCL1,
UVRAG,
CKAP4,
BMI1,
NTRK1,
MYCL,
MRTFA,
FHIT,
FOXP3,
MUC1,
CD200,
CD163,
MDM2,
MCC,
DNER,
MICA,
TTF1,
TP73,
SYP,
EGFR,
APC,
ETFA,
PTPRC,
AHR,
TLR4,
POSTN,
RPP14,
SDS,
TLR2,
TWIST1,
TNFRSF4,
SUB1,
IGF2BP3,
TMEFF1,
TYR,
SPHK1,
GNLY,
VIM,
YWHAE,
NDRG1,
CXCR4,
AXIN1,
CDK2AP2,
ZBTB24,
AXIN2,
FZD4,
RASSF1,
GPR65,
SELENBP1,
VEGFA,
ADAM10,
SF3B1,
MRGPRX1,
MRGPRX3,
MRGPRX4,
FOPNL,
CD200R1,
GPR151,
PRUNE2,
OXER1,
DDX53,
ASXL1,
GPRC6A,
MMS,
SPPL2A,
ABCB5,
SLC35B2,
LINC01194,
MIR203A,
VN1R17P,
GPR166P,
KRT8P3,
BCC1,
COMMD3-BMI1,
LOC110806263,
LMLN,
CCDC54,
BRD4,
TET2,
LPAR3,
CLIC4,
SGSM3,
LAMTOR2,
GPR132,
NKX2-1,
SH3GLB1,
SF3B6,
SPA17,
CCHCR1,
IMPAD1,
TMPRSS13,
IMP3,
FBXW7,
MMP26,
MRTFB,
EP400,
LGR6,
PIEZO2,
MMP28,
CD276,
ARHGAP24,
TLR1,
S100A9,
TERT,
GPR4,
EWSR1,
FCGR3A,
FCGR3B,
FGFR1,
FLI1,
FLII,
GJA1,
GPC3,
GLI1,
GUCY2D,
ERBB2,
HLA-A,
HLA-DRB1,
HRAS,
HSPA4,
HTC2,
IFNA2,
IL4,
IDO1,
KRAS,
ERBB3,
ENO2,
PRDX2,
MS4A1,
JAG1,
AKT1,
ALOX15,
BIRC5,
BAX,
CCND1,
BRAF,
CASP3,
CD9,
CD68,
DUSP2,
CD151,
CHGA,
CLIC1,
CLTA,
CCR4,
COL11A2,
CTNNB1,
SARDH,
ATN1,
KRT5,
KRT8,
LDHB,
SDHB,
POU4F3,
PTPA,
MAP2K7,
PTEN,
PTGS2,
PTPRG,
REST,
PARP1,
CCL17,
SELE,
SMAD4,
SHBG,
SHH,
SLN,
SNAI2,
SORD,
SOX2,
STAT3,
STAT5B,
TDO2,
POU3F2,
PECAM1,
PDGFA,
PAFAH1B1,
MCL1,
MCM4,
MCM6,
MCM7,
MDM4,
KITLG,
MGMT,
CD99,
MMP10,
MMP12,
MSMB,
MST1,
MST1R,
NEUROD1,
NGF,
NOTCH1,
NOTCH2,
NOTCH3,
PEBP1,
H3P8
Drugs
(S)-ethyl 2-amino-3-(4-(2-amino-6((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)- 2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate,
Avelumab
(
Bavencio
),
Gallium [Ga-68]-N-[(4,7,10-tricarboxymethyl-1,4,7,10-tetraazacyclododec-1-yl)acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophanyl-L-lysyl-L-threoninyl-Lcysteinyl-L-threonine-cyclic(2-7)disulfide
(
NETSPOT
)
(S)-ethyl 2-amino-3-(4-(2-amino-6((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)- 2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate,
Avelumab
(
Bavencio
),
Gallium [Ga-68]-N-[(4,7,10-tricarboxymethyl-1,4,7,10-tetraazacyclododec-1-yl)acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophanyl-L-lysyl-L-threoninyl-Lcysteinyl-L-threonine-cyclic(2-7)disulfide
(
NETSPOT
),
Live-attenuated non-replicative Pseudomonas aeruginosa strain expressing large T antigen of Merkel cell polyomavirus,
Maytansinoid-conjugated humanized monoclonal antibody against CD56
Registered!
Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. It usually develops as a single, painless, bump on sun-exposed skin. The bump may be skin-colored or red-violet, and tends to grow rapidly over weeks to months. It may spread quickly to surrounding tissues, nearby lymph nodes, or more distant parts of the body. Factors associated with developing MCC include increasing age, fair skin, a history of extensive sun exposure, chronic immune suppression, and the Merkel cell polyomavirus. This virus has been detected in about 80% of people with MCC. Treatment may include surgery, radiation therapy, and/or chemotherapy. Treatment options and prognosis depend on the location(s) and size of the cancer, whether it has just been diagnosed or has come back (recurred), and how deeply it has grown into the skin.