Rheumatoid Nodulosis

Watchlist

(log in to enable)

Retrieved

2019-09-22

Source

Omim

Trials

—

Genes

HLA-DRB1, IL1B, MMP3, RBM45, MMP12, PDCD1LG2, TLR9, CD274, SMUG1, VCAM1, TNF, SLC11A1, SELE, MTR, IL1A, IL1RN, IFNG, MMP1, MBL2, IL18, IL17A, IL15, IL10, IL4R, IL2, MMP7

Drugs

—

Interested in hearing about new therapies?

Clinical Features

Brown et al. (1979) described longstanding, multiple, subcutaneous nodules with the histopathologic characteristics of rheumatoid nodules, in 2 males without clinical or serologic evidence of rheumatic disease. No abnormality of leukocyte function was found. One patient had a positive family history with 7 persons (5 males) in 4 sibships of 3 generations affected. The nodules were located on the elbows, hands, heels and shin. Seemingly, only the proband was studied in the multiply affected family.