Optic Atrophy With Demyelinating Disease Of Cns

Lees et al. (1964) described a kindred in 5 generations of which 12 males and 3 females were affected with optic neuritis accompanied in some by neurologic manifestations resembling disseminated sclerosis. One had ataxia, right leg weakness and dysarthria. Another developed left hemiparesis during a 2-week period and then recovered partially. Went (1974) expressed the opinion that this kindred is an example of Leber optic atrophy (535000) and not a separate entity.