Frontotemporal Dementia
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
GRN,
MAPT,
PSEN1,
TARDBP,
CHMP2B,
C9orf72,
TREM2,
SQSTM1,
UBQLN2,
CHCHD10,
FUS,
TBK1,
TMEM106B,
VCP,
HNRNPA1,
DCTN1,
HNRNPA2B1,
PRKAR1B,
WASHC5,
RAB38,
BTNL2,
SNCA,
SOD1,
LINC01867,
NEFL,
MEF2C,
IGFALS,
HLA-DRB9,
NDUFS1,
GFRA2
GRN,
MAPT,
PSEN1,
TARDBP,
CHMP2B,
C9orf72,
TREM2,
SQSTM1,
UBQLN2,
CHCHD10,
FUS,
TBK1,
TMEM106B,
VCP,
HNRNPA1,
DCTN1,
HNRNPA2B1,
PRKAR1B,
WASHC5,
RAB38,
BTNL2,
SNCA,
SOD1,
LINC01867,
NEFL,
MEF2C,
IGFALS,
HLA-DRB9,
NDUFS1,
GFRA2,
ZFYVE26,
APOE,
ST18,
TSBP1-AS1,
ATP9B,
COL28A1,
NDUFAF8,
TEPSIN,
CEP131,
TNIK,
PLA2G6,
FUT10,
PRNP,
LAMC2,
CSF2,
PSEN2,
GEMIN4,
EIF4G2,
CFDP1,
PSMD2,
OPTN,
CHI3L1,
ATXN2,
TIA1,
APP,
LRRK2,
DCTN4,
PTBP1,
KHDRBS1,
NUP62,
GTF2H1,
CTSD,
CCNF,
PFN1,
GRIA3,
SMUG1,
RBM8A,
PSPN,
SRRM2,
PNO1,
BCHE,
PCBP2,
MAK16,
MSMB,
BPIFA2,
RBMS3,
EWSR1,
PSPH,
GFAP,
RIDA,
RAN,
REG1A,
STXBP3,
HNRNPA1P10,
CHCHD2,
CASP2,
RRM1,
PIK3R4,
SFPQ,
SETX,
NRGN,
SORT1,
PIN1,
RMDN1,
CASP3,
SYBU,
ACHE,
PSAP,
RMDN3,
RAB3GAP2,
ABL1,
MIR659,
CHAF1A,
HNRNPH2,
TOMM40,
CLU,
RIPK1,
ANPEP,
ELP1,
TSBP1,
LAMP1,
STH,
LMNA,
HNRNPH1,
FLNC,
TAF15,
RMDN2,
GAP43,
CTR9,
MMP9,
CALCOCO2,
CHMP2A,
SPAG8,
CDK6,
SIGMAR1,
GNE,
HNRNPR,
GLCE,
ALYREF,
CTSC,
L3MBTL1,
DKK1,
SPTLC1,
SYNCRIP,
ZNF629,
CIT,
UNC13A,
TPPP,
KDM1A,
CDK1,
SARM1,
STMN2,
CARM1,
CBS,
RNPS1,
MASP2,
PDLIM5,
RBMX,
ATG7,
CDK5,
SLC25A38,
SGSM3,
CAMK2A,
MFSD8,
NEAT1,
APEX1,
ZNF763,
MCIDAS,
CDRT1,
ALB,
TMEM189,
TMEM189-UBE2V1,
KMT5A,
ADARB1,
MIR127,
MIR181C,
MIR204,
MIR206,
MIR210,
MIR29B1,
MIR29B2,
PSG8,
MIR632,
AAA1,
LINC01672,
ADA,
APOC1,
PTCRA,
ZNF569,
ATP5F1A,
UBN1,
FMNL1,
BRCA1,
DCUN1D1,
CYCS,
BNIP1,
TMED9,
ELP2,
TDP1,
ZNF253,
SMURF1,
APOD,
ERGIC1,
AARS2,
SH3RF1,
PTBP2,
CHMP6,
SPG11,
ZNF436,
DNER,
RBM45,
TTBK2,
HNRNPDL,
AFF2,
CEACAM4,
NOTCH3,
DNM2,
MMP2,
ND1,
CEACAM6,
DNAH8,
NEFM,
NEFH,
DLD,
NFKB2,
NONO,
NOS2,
NPY,
NSF,
MATR3,
NUP98,
SERPINF1,
PGF,
PHF1,
SERPINI1,
POLD1,
DECR1,
MAPK3,
MAPK8,
DDX3X,
DCT,
ACE,
DNMT1,
MAOA,
LEP,
LCN2,
FMR1,
GABRB2,
GLDC,
GNA12,
F11,
GSK3B,
HCRT,
HTT,
HLA-DRB1,
EXT2,
HMBS,
EXT1,
HNRNPC,
HRES1,
HSPA4,
IFNA1,
IFNA13,
IGF1,
ERBB4,
CXCL8,
IRF7,
ITGB2,
KIF5A,
LAD1,
DPP6,
PSG1,
PSG2,
PSG7,
VEGFA,
XPO1,
XRCC5,
TFPI2,
AAAS,
PABPN1,
PICALM,
BAP1,
CDC7,
CRHR1,
SRSF9,
NAPG,
SUCLA2,
FRAXE,
RAB29,
HAP1,
MAP3K14,
CLDN2,
INA,
ITM2B,
MAP4K4,
EIF2AK3,
SLC25A27,
ADAMTS2,
NPEPPS,
CHIT1,
WNT5A,
CSNK1D,
PYY,
SUMO1,
DAPK1,
RANBP2,
RPS25,
RREB1,
CYP27A1,
SRSF3,
SRSF4,
ST3GAL4,
SLC6A3,
SLC6A4,
SLC18A2,
SMARCA1,
SNAP25,
CYP2D6,
SST,
SYN1,
MAP3K7,
TEAD1,
TIMP1,
TNF,
NR2C2,
TRP-AGG2-6,
TUBA4A,
TYRO3,
UBE2V1,
CDK5R1
Registered!
Frontotemporal dementia (FTD) comprises a group of neurodegenerative disorders, characterized by progressive changes in behavior, executive dysfunction and language impairment, as a result of degeneration of the medial prefrontal and frontoinsular cortices. Four clinical subtypes have been identified: semantic dementia, progressive non-fluent aphasia, behavioral variant FTD and right temporal lobar atrophy (see these terms).