Diabetes Mellitus, Insulin-Dependent, 24

Mapping

Barrett et al. (2009) reported the findings of a genomewide association study of type 1 diabetes (IDDM; see 222100), combined in a metaanalysis with 2 previously published studies (Wellcome Trust Case Control Consortium, 2007; Cooper et al., 2008). The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with type 1 diabetes in the metaanalysis (P less than 10(-6)). Using an analysis that combined comparisons over the 3 studies, Barrett et al. (2009) confirmed several previously reported associations. Barrett et al. (2009) further tested 27 novel regions in an independent set of 4,267 cases and 4,463 controls, and 2,319 affected sib pair families. Of these, 18 regions were replicated (P less than 0.01; overall P less than 5 x 10(-8)) and 4 additional regions provided nominal evidence of replication. The strongest evidence of association among these novel regions was achieved at rs10509540 (combined P = 1.3 x 10(-28)), on chromosome 10q23.31 near the RNLS gene (609360).

Possible Role in Insulin-Dependent Diabetes Mellitus

For discussion of a possible role of the SIRT1 gene in type 1 diabetes mapping to 10q23, see 604479.0001.