Acute Liver Failure
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
TNF,
ATP7B,
HGF,
FAS,
ALB,
IL1RN,
GC,
MAPK8,
KRT8,
KRT18,
GFER,
FASLG,
CSF3,
SERPINC1,
CAST,
GPNMB,
PANX1,
CD74,
FST,
POMC,
SCO1,
ALDOB,
INHBA,
INS,
IL6,
TLR4,
CASP3,
NOS3,
PTGS2,
ABCC2
TNF,
ATP7B,
HGF,
FAS,
ALB,
IL1RN,
GC,
MAPK8,
KRT8,
KRT18,
GFER,
FASLG,
CSF3,
SERPINC1,
CAST,
GPNMB,
PANX1,
CD74,
FST,
POMC,
SCO1,
ALDOB,
INHBA,
INS,
IL6,
TLR4,
CASP3,
NOS3,
PTGS2,
ABCC2,
NOS2,
MET,
CD14,
CASP9,
ATM,
KCNJ10,
PTAFR,
CASP12,
UCP2,
COL1A2,
HSPA8,
FGA,
BRIP1,
THBD,
INS-IGF2,
LTC4S,
NBAS,
POLG,
RINT1,
TRMU,
FAH,
POLG2,
JAK2,
SCYL1,
MST1,
PORCN,
HADH,
GPT,
GPR35,
VPS13A,
MPV17,
ITCH,
F5,
CYC1,
RYR1,
GFM1,
ACAD9,
IKZF1,
MEFV,
CACNA1S,
EIF2AK3,
LARS1,
TCF4,
HLA-B,
HMGB1,
IL1B,
F2,
CCL4,
IL10,
MIR122,
HMOX1,
PPARA,
STON1,
AFM,
GTF2A1L,
MIR223,
NLRP3,
SLC1A2,
HDAC2,
STON1-GTF2A1L,
HDAC6,
MSC,
IL1A,
UGT1A,
TP53,
SLC17A5,
ABCG2,
SYT1,
CXCL12,
PEBP1,
OTC,
PRKAA1,
RELA,
WNK1,
BCHE,
AFP,
IFNG,
AHSG,
GORASP1,
GSK3B,
PIM3,
DDIT3,
DGUOK,
EXOSC3,
BCL2L11,
MIR17,
MFN2,
MIR155,
ABCB6,
AIM2,
BTBD8,
YAP1,
IFNL3,
PPARGC1B,
APOA5,
PIK3IP1,
LMLN,
MIR19A,
LONP1,
MIR210,
ATG7,
PPIG,
MIR214,
RGN,
TIMELESS,
SQSTM1,
MIR375,
MIR1224,
TNFRSF10B,
RIPK1,
OCLN,
BECN1,
SOCS1,
ARHGEF5,
SHANK3,
KHDRBS1,
TXNIP,
KCTD9,
HAMP,
ACKR3,
NAT10,
HAVCR1,
SIGLEC9,
PDLIM3,
IGHV1-3,
ATRNL1,
TLR9,
STX18,
ERO1A,
SCLC1,
RRM2B,
SLC25A37,
CXCL16,
NUP62,
SERAC1,
SLC27A5,
DCTN4,
CYSLTR1,
CCL27,
SLA2,
EVA1A,
TMPRSS13,
SESN2,
SIRT1,
PARP9,
ASRGL1,
DHDDS,
GSDMD,
SIRT2,
TBC1D9,
TFEB,
ACADM,
VWF,
GABPA,
CYP2E1,
CYP3A4,
ESR1,
FABP1,
FABP7,
FBP1,
FCGR3A,
FCGR3B,
FOXO3,
G6PD,
GFAP,
VIP,
CXCR3,
GTF2H1,
HIF1A,
HNF4A,
HSPA5,
HSPG2,
ID1,
IFNA1,
IFNA13,
IFNB1,
CYP1A2,
CX3CR1,
CTNNB1,
CTLA4,
AHR,
AKT1,
ALAS1,
ALPP,
AMCN,
AQP4,
AR,
ATHS,
BCL2,
OPN1SW,
BID,
BST2,
CASP8,
CD86,
ENTPD1,
CD40LG,
CEL,
CGA,
CCR5,
KLF6,
CRP,
IL1R1,
IL2,
CXCL8,
S100A10,
CCL2,
SDC1,
SLC6A12,
SLC12A2,
SLPI,
SOAT1,
STAR,
STAT1,
STAT3,
MAP3K7,
PPP1R11,
TGFB1,
TGFBR2,
THBS1,
THPO,
TLR2,
TLR3,
TNFAIP3,
TNFAIP6,
TXN,
UGT2B7,
S100A12,
RHD,
IL18,
ACP3,
ITGAM,
MARS1,
KMT2A,
MPO,
MSMB,
COX2,
MYD88,
NFE2L2,
NT5E,
SERPINE1,
ABCB1,
PIK3CA,
PIK3CB,
PIM1,
PIK3CD,
PIK3CG,
SERPINF2,
PPP2R5A,
PRKAA2,
PRKAB1,
RBP4,
MTCO2P12
Drugs
Cardiotrophin-1,
Heterologous human adult liver derived stem cells
(
Promethera HepaStem
),
Human heterologous liver cells (for infusion)
Cardiotrophin-1,
Heterologous human adult liver derived stem cells
(
Promethera HepaStem
),
Human heterologous liver cells (for infusion),
Immortalised human C3A hepatoblastoma cells,
Ornithine phenylacetate,
Recombinant human hepatocarcinoma-intestine-pancreas / pancreatic associated protein,
human hepatoma cell line HepaRG in bioartificial liver
Registered!
A rare hepatic disease characterized by acute onset of severe liver dysfunction without evidence of underlying chronic liver disease. Patients present with nonspecific symptoms like jaundice, upper right abdominal pain, nausea, vomiting, pruritus, fatigue, and fever. The condition may rapidly progress to hepatic encephalopathy, coagulopathy, and life-threatening multiorgan failure. Liver biopsy typically shows massive hepatic necrosis.