Acral Peeling Skin Syndrome

Acral peeling skin syndrome is a genetic skin disorder characterized by painless peeling of the top layer of skin. "Acral" refers to the fact that the peeling is most apparent on the hands and feet, although peeling may also occur on the arms and legs. The peeling is usually present from birth, but can appear later in childhood or early adulthood. Acral peeling skin syndrome can be caused by mutations in the TGM5 gene. Mutations in the CSTA gene have also been linked to this condition. It is inherited in an autosomal recessive pattern. There is no cure for acral peeling skin syndrome. Treatment is aimed at treating the symptoms present in each individual.