Van Bogaert-Hozay Syndrome

Van Bogaert (1953) and Hozay (1953) described a form of acroosteolysis with facial abnormalities in a brother and sister, aged 27 and 28, respectively. The parents were distantly related. The fingers and toes appeared infantile. The distal end of the ulna was underdeveloped. The facies were characterized by flat nasal bridge, thickened cheeks, deformed ears, micrognathia with abnormal dental position, and absent beard. Myopia and astigmatism were present. The male was mildly retarded; the female had done well in school.

Ludo van Bogaert (1897-1989) lived and worked all his life in Antwerp, Belgium. As a neurologist and neuropathologist, he was a master of clinicopathologic correlation (Karcher, 1990).