Preeclampsia/eclampsia 3

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Retrieved

2019-09-22

Source

Omim

Trials

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Genes

NOS3, STOX1, CORIN, FLT1, AGT, ACE, SERPINE1, EPHX1, EDN1, INHBA, CP, SCNN1A, HMOX1, ARHGAP45, DDAH2, ANXA5, ENG, LEP, PGF, LEPR, ICAM1, TLR3, CCL5, PTGS1, PDE5A, CYP2J2, C3, AKR1C3, COMT, IDO1

NOS3, STOX1, CORIN, FLT1, AGT, ACE, SERPINE1, EPHX1, EDN1, INHBA, CP, SCNN1A, HMOX1, ARHGAP45, DDAH2, ANXA5, ENG, LEP, PGF, LEPR, ICAM1, TLR3, CCL5, PTGS1, PDE5A, CYP2J2, C3, AKR1C3, COMT, IDO1, CD40LG, NOTCH2, ASB4, ITGA4, F5, CYP11B2, CFI, EED, HBA1, HBA2, PPARG, LBR, SOS1, CD46, GNAS, HELLPAR, CFH, NSD1, FGF14, SLC25A20, ADGRG6, CYP11B1, DHPS, ZMPSTE24, MYCBP2, ZNF295-AS1, TMEM94, KMT2B, AGTR1, ADM, VEGFA, IGFBP1, INHA, MTHFR, IL16, MMP9, MBL2, THBD, ERVW-1, SELP, ADIPOQ, TLR4, TNF, IL10, CSF1, PLAC1, GCM1, SYNPO, KIR3DL3, S100B, TAP1, TAC3, SOCS3, APLN, TDO2, SLC1A5, EBAG9, SELL, FLT1P1, SELE, CD24, TAP2, NOD2, TEK, PROZ, TFPI, ADAMTS13, TGFB1, ADAM12, VWF, VCAM1, LGALS13, NOX1, TIMP2, TPBG, TLR2, SERBP1, NAT2, REN, CGB3, SERPIND1, GSTP1, GH2, FABP4, F2, ESR1, EFNA1, CRP, CRH, CPB2, CLU, CHRNA7, TNFRSF8, PYGM, CALR, CALCA, BOK, BDKRB2, ANGPT2, APLNR, AGTR2, ADRB3, ADRB2, ADORA2B, ADA, ACVR2A, HDC, HIF1A, HLA-G, HP, PTX3, PSG5, HTRA1, PRCP, PON1, PEE1, ENPP1, OLR1, NPHS1, CCN3, NOS2, ACTG2, LGALS1, CXCL10, IL18, IL15, IL6ST, IL6, IL4, CCN1, IGF2, IGF1, IFNGR2, IFNG, HSD11B2, LIPC

Drugs

Digoxin immune FAB (Ovine) ( DIGIBIND ), Recombinant human alpha-1-microglobulin, S-nitrosoglutathione

Digoxin immune FAB (Ovine) ( DIGIBIND ), Recombinant human alpha-1-microglobulin, S-nitrosoglutathione, recombinant human placental growth factor

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For a general phenotypic description and a discussion of genetic heterogeneity of preeclampsia, see PEE1 (189800).

Mapping

Hypothesizing that the genetic background of preeclampsia might show reduced heterogeneity in a founder population such as that of the Kainuu province in central eastern Finland, Laivuori et al. (2003) performed a genomewide scan in 15 multiplex families in that area. They found 2 loci that exceeded the threshold for significant linkage: 2p25, at 21.70 cM (PEE2; 609402), and 9p13 (PEE3), at 38.90 cM.