Generalized Lymphadenopathy

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Retrieved
2021-01-18
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Generalized lymphadenopathy is swollen lymph glands in many areas of the body.

Usually this is in response to a body-wide infectious disease such as influenza and will go away once the person has recovered, but sometimes it can persist long-term, even when there is no obvious cause of disease. This is then called persistent generalized lymphadenopathy (PGL).

Causes of generalized lymphadenopathy

  • Infection :
    • Viral : Infectious mononucleosis, Infective hepatitis, AIDS
    • Bacterial : Tuberculosis, Brucellosis, secondary syphilis, Tularemia
    • Protozoal : Toxoplasmosis
    • Fungal : Histoplasmosis
  • Malignant :
    • Leukaemia
    • Metastatic carcinoma
  • Immunological :
    • Systemic lupus erythematosus
    • Felty's syndrome
    • Still's disease
    • Drug hypersensitivity as Hydantoin, Hydralazine, Allopurinol
  • Misc. :
    • Sarcoidosis
    • Amyloidosis
    • Lipid storage disease
    • Hyperthyroidism