Teratoma, Pineal

From Japan, Wakai et al. (1980) described 2 teenage brothers with pineal teratoma. The parents were not related. Both showed upward gaze palsy and horizontal nystagmus with lateral gaze. One showed abnormal intracranial calcification on plain skull film. One presented at age 13 years with a 7-month history of polydipsia, polyuria and loss of appetite. The second presented at age 17 years with progressive right-sided hemiparesis and a 2-year history of diplopia. The familial occurrence of presacral teratoma is noted elsewhere (176450). As noted by Wakai et al. (1980), medulloblastoma has been reported in sibs on a number of occasions and occurs as part of the basal cell nevus syndrome (109400). Schimke (1983) described a paraventricular germinoma in a 22-year-old male whose paternal uncle had a benign cystic teratoma removed from his mediastinum at the age of 18 years.