Graham Little-Piccardi-Lassueur Syndrome

A variant of lichen planopilaris characterized by the clinical triad of progressive cicatricial (scarring) alopecia of the scalp, follicular keratotic papules on glabrous skin, and variable alopecia of the axillae and groin.

Epidemiology

It is a very rare disease but the exact prevalence is not known. It mainly affects women during adulthood (30-60 years of age).

Clinical description

Scarring alopecia presents as small confluent patches that are atrophic and cicatricial in the center but erythematous and squamous around the edges. Follicular keratosis presents as pruritic, red-brown, follicular spiny papules on the trunk and extremities. Generally, the three clinical features appear simultaneously but in some cases, scalp alopecia precedes the follicular keratosis.

Etiology

Etiology is unknown.