Liposarcoma

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Retrieved

2021-01-23

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Orphanet

Trials

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Genes

CDK4, FRS2, FASN, YEATS4, NF1, CDK6, IL22, FUS, TP53, MDM2, DDIT3, PPARG, HMGA2, CD6, CDKN2A, MIR155, TBC1D9, TARDBP, PLIN1, CD274, ABCB1, MIR193B, EWSR1, MXLPO, HCCS, FOLH1, PNPLA2, TSN, NANS, PIK3CA, MBTPS2, HSP90AA1, AURKA, AKT1, CRK, SREBF1, PTEN, TERT, CTAG1A, CAVIN1, CTAG1B, TSPAN31, MAP3K5, RET, CAVIN2, KL, EIF2S2, DYRK1B, TAF15, PER2, AIMP2, MBTPS1, TRIO, PAX8, ZIC1, XPO1, VIM, GPNMB, TOP2A, TIMP4, TIMP1, THRSP, TCN1, TAL1, TAF12, STC1, STAT6, STAT3, GRAP2, A2M, IFI44, MIR143, PNPLA3, CRISPLD2, IMMP2L, DNER, MYOCD, SPPL3, PDIK1L, CENPV, MIR144, AHSA1, MIR145, MIR214, MIR25, MIR26A2, MIR451A, BCRP1, CCDC180, LOC107228383, PRUNE1, TP53INP2, MEPE, HEATR3, IGF2BP2, SPIN1, SOX21, RASSF1, ATF6, CDK19, TAB2, SOX10, SMUG1, RNF19A, WWTR1, DNM3, POLDIP2, FGF21, FOXP1, EML4, G0S2, SRC, PTK2, SOX2, FGFR1, HBEGF, E2F1, E2F4, EGFR, EIF2S1, EIF2S3, EIF4E, EPAS1, GDNF, CTNNB1, GH1, GHR, GNAS, GPS2, HMBS, HMGB2, HMGA1, HOXA5, DAXX, CSF1R, HTC2, CAPN3, PARP1, APC, APCS, STS, ATP2A2, CCND1, BCL2, CALR, CASP10, MAPK14, CAV2, CCK, CD38, CDK11B, CEBPB, CHEK1, KLF6, CPM, HOXC13, IGF1, SOD1, MAPK1, PDGFRB, PER1, PIK3CB, PIK3CD, PIK3CG, PLAG1, PLK1, PML, PSMD8, OSBP, PLIN2, PTK7, PTX3, RASA2, RPS14, S100A4, SBF1, SDC1, PDGFRA, DDR2, IGF2, LEPR, IGFBP5, IL6, JUN, KCNH1, KIT, LBR, LDLR, LEP, LPP, YBX1, MAZ, MDM4, MLH1, MMP2, MSH2, MSRA, MYC, NAB2, H3P10

Drugs

(-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1yl)-4-(1H-indol-3-yl) pyrrolidine-2, 5-dione, (1-methyl-2-nitro-1H-imidazole-5-yl)methyl N,N'-bis(2-bromoethyl) diamidophosphate, (3'R,4'S,5'R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6''-chloro-4'-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2''-oxo-1'',2''-dihydrodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indole]-5'-carboxamide mono(4-methylbenzenesulfonate) monohydrate, 16-base single-stranded peptide nucleic acid oligonucleotide linked to a 7-amino acid peptide, 18-(p-(, 4-oxo-4H-chromene-2-carboxylic acid (2-(2-4-(2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl)-phenyl-2H-tetrazol-5-yl)-4,5-dimethoxy-phenyl)-amide, 7-ethyl-10-hydroxy-camptothecin, Anlotinib, Autologous CD4+ and CD8+ T cells transduced with a lentiviral vector encoding an affinity enhanced T cell receptor specific to MAGE-A4, Autologous CD4+ and CD8+ T cells transduced with lentiviral vector containing an affinity-enhanced T-cell receptor targeting the New York esophageal antigen-1, Brostallicin, Camsirubicin, Crenolanib besylate, Deforolimus, Doxorubicin hydrochloride (liposomal) ( DOXIL ), Doxorubicin(6-maleimidocaproyl)hydrazone, Fenretinide, Fibromun, Genetically modified serotype 5/3 adenovirus coding for granulocyte-macrophage colony-stimulating factor, Glucopyranosyl lipid A stable emulsion and recombinant New York oesophageal squamous cell carcinoma-1 protein (NY-ESO-1), Human/murine chimeric monoclonal antibody against endoglin, Larotrectinib ( VITRAKVI ), Mammalian target of rapamcyin (mTOR) inhibitor, N-acetylsarcosyl-glycyl-L-valyl-D-allo-isoleucyl-L-threonyl-L-norvalyl-L-isoleucyl-L-arginyl-L-prolyl-N-ethylamide, Olaratumab ( LARTRUVO ), Ombrabulin, Paclitaxel ( TAXOL ), Palifosfamide, Propranolol hydrochloride ( HEMANGEOL ), Sindbis virus envelope pseudotyped lentiviral vector encoding New York oesophageal squamous cell carcinoma-1 protein, Trabectedin ( YONDELIS ), Vinorelbine tartrate, Yttrium (90Y)-DTPA-radiolabelled chimeric monoclonal antibody against frizzled homologue 10

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Liposarcoma (LS), a type of soft tissue sarcoma, describes a group of lipomatous tumors of varying severity ranging from slow-growing to aggressive and metastatic. Liposarcomas are most often located in the lower extremities or retroperitoneum, but they can also occur in the upper extremities, neck, peritoneal cavity, spermatic cord, breast, vulva and axilla.

Epidemiology

Liposarcomas account for approximately 15-20% of all soft tissue sarcomas. The incidence is approximately 1 per 100, 000 persons/years.

Clinical description

They can affect all age groups but are most frequently seen in middle-aged and older adults. Liposarcomas are classified into 4 biological groups (encompassing five histological subtypes): well-differentiated (WDLS), dedifferentiated (DDLS), myxoid /round cell (MRCLS) and pleomorphic (PLS) (see these terms).

Etiology

The etiology is unknown but many chromosomal aberrations are found in liposarcomas.

Prognosis

The prognosis is dependent on the specific subtype, size, stage and location of the disease.