Allergies

Overview

Allergies occur when your immune system reacts to a foreign substance — such as pollen, bee venom or pet dander — or a food that doesn't cause a reaction in most people.

Your immune system produces substances known as antibodies. When you have allergies, your immune system makes antibodies that identify a particular allergen as harmful, even though it isn't. When you come into contact with the allergen, your immune system's reaction can inflame your skin, sinuses, airways or digestive system.

The severity of allergies varies from person to person and can range from minor irritation to anaphylaxis — a potentially life-threatening emergency. While most allergies can't be cured, treatments can help relieve your allergy symptoms.

Symptoms

Allergy symptoms, which depend on the substance involved, can affect your airways, sinuses and nasal passages, skin, and digestive system. Allergic reactions can range from mild to severe. In some severe cases, allergies can trigger a life-threatening reaction known as anaphylaxis.

Hay fever, also called allergic rhinitis, can cause:

• Sneezing
• Itching of the nose, eyes or roof of the mouth
• Runny, stuffy nose
• Watery, red or swollen eyes (conjunctivitis)

A food allergy can cause:

• Tingling in the mouth
• Swelling of the lips, tongue, face or throat
• Hives
• Anaphylaxis

An insect sting allergy can cause:

• A large area of swelling (edema) at the sting site
• Itching or hives all over the body
• Cough, chest tightness, wheezing or shortness of breath
• Anaphylaxis

A drug allergy can cause:

• Hives
• Itchy skin
• Rash
• Facial swelling
• Wheezing
• Anaphylaxis

Atopic dermatitis, an allergic skin condition also called eczema, can cause skin to:

• Itch
• Redden
• Flake or peel

Anaphylaxis

Some types of allergies, including allergies to foods and insect stings, can trigger a severe reaction known as anaphylaxis. A life-threatening medical emergency, anaphylaxis can cause you to go into shock. Signs and symptoms of anaphylaxis include:

• Loss of consciousness
• A drop in blood pressure
• Severe shortness of breath
• Skin rash
• Lightheadedness
• A rapid, weak pulse
• Nausea and vomiting

When to see a doctor

You might see your health care provider if you have symptoms you think are caused by an allergy, and nonprescription allergy medications don't provide enough relief. If you have symptoms after starting a new medication, call the provider who prescribed it right away.

For a severe allergic reaction (anaphylaxis), call 911 or your local emergency number or seek emergency medical help. If you carry an epinephrine auto-injector (Auvi-Q, EpiPen, others), give yourself a shot right away.

Even if your symptoms improve after an epinephrine injection, you should go to the emergency department to make sure symptoms don't return when the effects of the injection wear off.

If you've had a severe allergy attack or any signs and symptoms of anaphylaxis in the past, make an appointment to see your health care provider. Evaluation, diagnosis and long-term management of anaphylaxis are complicated, so you'll probably need to see a provider who specializes in allergies and immunology.

Causes

An allergy starts when your immune system mistakes a normally harmless substance for a dangerous invader. The immune system then produces antibodies that remain on the alert for that particular allergen. When you're exposed to the allergen again, these antibodies can release a number of immune system chemicals, such as histamine, that cause allergy symptoms.

Common allergy triggers include:

• Airborne allergens, such as pollen, animal dander, dust mites and mold
• Certain foods, particularly peanuts, tree nuts, wheat, soy, fish, shellfish, eggs and milk
• Insect stings, such as from a bee or wasp
• Medications, particularly penicillin or penicillin-based antibiotics
• Latex or other substances you touch, which can cause allergic skin reactions

Risk factors

You might be more likely to develop an allergy if you:

• Have a family history of asthma or allergies, such as hay fever, hives or eczema
• Are a child
• Have asthma or another allergic condition

Complications

Having an allergy increases your risk of certain other medical problems, including:

• Anaphylaxis. If you have severe allergies, you're at increased risk of this serious allergy-induced reaction. Foods, medications and insect stings are the most common triggers of anaphylaxis.
• Asthma. If you have an allergy, you're more likely to have asthma — an immune system reaction that affects the airways and breathing. In many cases, asthma is triggered by exposure to an allergen in the environment (allergy-induced asthma).
• Sinusitis and infections of the ears or lungs. Your risk of getting these conditions is higher if you have hay fever or asthma.

Prevention

Preventing allergic reactions depends on the type of allergy you have. General measures include the following:

• Avoid known triggers. Even if you're treating your allergy symptoms, try to avoid triggers. If, for instance, you're allergic to pollen, stay inside with windows and doors closed when pollen is high. If you're allergic to dust mites, dust and vacuum and wash bedding often.
• Keep a diary. When trying to identify what causes or worsens your allergic symptoms, track your activities and what you eat, when symptoms occur and what seems to help. This may help you and your provider identify triggers.
• Wear a medical alert bracelet. If you've had a severe allergic reaction, a medical alert bracelet (or necklace) lets others know that you have a serious allergy in case you have a reaction and you're unable to communicate.

Diagnosis

To evaluate whether you have an allergy, your health care provider will likely:

• Ask detailed questions about signs and symptoms
• Perform a physical exam
• Have you keep a detailed diary of symptoms and possible triggers

If you have a food allergy, your provider will likely:

• Ask you to keep a detailed diary of the foods you eat
• Ask if you've stopped eating the suspected food during the allergy evaluation

Your provider might also recommend one or both of the following tests. However, be aware that these allergy tests can be falsely positive or falsely negative.

• Skin test. Your skin will be pricked with small amounts of the proteins found in common allergens. If you're allergic, you'll likely develop a raised bump (hive) at the test location on your skin.
• Blood test. Specific IgE (sIgE) blood testing, commonly called radioallergosorbent test (RAST) or ImmunoCAP testing, measures the amount of allergy-causing antibodies in your bloodstream, known as immunoglobulin E (IgE) antibodies. A blood sample is sent to a medical laboratory, where it can be tested for evidence of sensitivity to possible allergens.

If your provider suspects your problems are caused by something other than an allergy, other tests might help identify — or rule out — other medical problems.

Treatment

Allergy treatments include:

• Allergen avoidance. Your provider will help you take steps to identify and avoid your allergy triggers. This is generally the most important step in preventing allergic reactions and reducing symptoms.
• Medications. Depending on your allergy, medications can help reduce your immune system reaction and ease symptoms. Your provider might suggest nonprescription or prescription medication in the form of pills or liquid, nasal sprays, or eyedrops.

• Immunotherapy. For severe allergies or allergies not completely relieved by other treatment, your provider might recommend allergen immunotherapy. This treatment involves a series of injections of purified allergen extracts, usually given over a period of a few years.

  Another form of immunotherapy is a tablet that's placed under the tongue (sublingual) until it dissolves. Sublingual drugs are used to treat some pollen allergies.

• Emergency epinephrine. If you have a severe allergy, you might need to carry an emergency epinephrine shot at all times. Given for severe allergic reactions, an epinephrine shot (Auvi-Q, EpiPen, others) can reduce symptoms until you get emergency treatment.

Clinical trials

Explore Mayo Clinic studies testing new treatments, interventions and tests as a means to prevent, detect, treat or manage this condition.

Lifestyle and home remedies

Some allergy symptoms improve with home treatment.

• Sinus congestion and hay fever symptoms. These often improve with saline nasal irrigation — rinsing out the sinuses with a salt and water solution. You can use a neti pot or a specially designed squeeze bottle to flush out thickened mucus and irritants from your nose. However, improper use of a neti pot or other device can lead to infection.
• Household airborne allergy symptoms. Reduce your exposure to dust mites or pet dander by frequently washing bedding and stuffed toys in hot water, maintaining low humidity, regularly using a vacuum with a fine filter such as a high-efficiency particulate air (HEPA) filter and replacing carpeting with hard flooring.
• Mold allergy symptoms. Reduce moisture in damp areas, such as your bath and kitchen, by using ventilation fans and dehumidifiers. Fix leaks inside and outside your home.

Alternative medicine

Clinical practice guidelines suggest that some people with allergic rhinitis may benefit from acupuncture.

Preparing for your appointment

For symptoms that could be caused by an allergy, see your primary health care provider. You might be referred to a provider who specializes in treating allergies (allergist).

What you can do

Ask if you should stop taking allergy medications before your appointment, and for how long. For example, antihistamines can affect the results of an allergy skin test.

Make a list of:

• Your symptoms, including any that seem unrelated to allergies, and when they began
• Your family's history of allergies and asthma, including specific types of allergies, if you know them
• All medications, vitamins and other supplements you take, including doses
• Questions to ask during your appointment

Some basic questions to ask include:

• What is the most likely cause of my signs and symptoms?
• Are there other possible causes?
• Will I need allergy tests?
• Should I see an allergy specialist?
• What treatment do you recommend?
• I have these other health conditions. How can I best manage them together?
• What emergency symptoms should my friends and family be aware of?

Don't hesitate to ask other questions.

What to expect from your doctor

Your provider is likely to ask you questions, including:

• Have you recently had a cold or other respiratory infection?
• Are your symptoms worse at certain times of the day?
• Does anything seem to improve or worsen your symptoms?
• Are your symptoms worse in certain areas of your house or at work?
• Do you have pets, and do they go into bedrooms?
• Is there dampness or water damage in your home or workplace?
• Do you smoke, or are you exposed to secondhand smoke or other pollutants?
• What treatments have you tried so far? Have they helped?