Discoid Lupus Erythematosus
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
CYBB,
CR2,
C2,
C5,
TSPYL2,
SPP1,
C1QA,
STAT4,
IRAK1,
NCF2,
IL10,
IL6,
IL2,
C1R,
TLR9,
IL21,
TNF,
IFNA1,
CD40LG,
FCGR2B,
TRIM21,
DNMT1,
CYBA,
IL17A,
IFNA13,
IRF5,
TLR7,
NCF1,
CD70,
TNFSF13B
CYBB,
CR2,
C2,
C5,
TSPYL2,
SPP1,
C1QA,
STAT4,
IRAK1,
NCF2,
IL10,
IL6,
IL2,
C1R,
TLR9,
IL21,
TNF,
IFNA1,
CD40LG,
FCGR2B,
TRIM21,
DNMT1,
CYBA,
IL17A,
IFNA13,
IRF5,
TLR7,
NCF1,
CD70,
TNFSF13B,
TLR5,
IL1B,
MTOR,
ITGAM,
TREX1,
RO60,
ESR1,
BTK,
IFNG,
FLI1,
MAPK1,
IL22,
TRBV20OR9-2,
CTLA4,
HLA-DRB1,
CD28,
TP53BP1,
BLK,
ITGAL,
RAB4A,
IFIH1,
FCGR3A,
CCL2,
FOXP3,
MBL2,
EZH2,
RNPC3,
EPHB2,
ICOS,
PRL,
ACE,
CRP,
TLR4,
PBX1,
STAT1,
MECP2,
AIM2,
PTPN22,
IL4,
FCGR3B,
IL2RA,
KIR3DL2,
C3,
CD44,
TGFB1,
ITGB2,
F11R,
BTG3,
DECR1,
BANK1,
IFN1@,
IRF7,
HDAC6,
IFI16,
HRES1,
ISG20,
MYDGF,
IGHG3,
CXCL12,
FLII,
RFX1,
MAVS,
F5,
IL18,
KIR3DL1,
FCGR2A,
CBLIF,
GEM,
CXCL10,
F3,
CASP1,
STAT3,
MIR31,
CALR,
CAMK4,
CREM,
BCR,
MIR21,
VEGFA,
APOH,
MIR146A,
TNFRSF17,
TLR8,
AR,
FASLG,
CXADRP1,
ARR3,
BCL2,
CXCR5,
IL17D,
PRDM1,
TRIM13,
KIR2DS1,
IL1A,
TREM1,
IFNAR1,
MIR155,
CASR,
TLR2,
MIR148A,
IRAK4,
MIR663A,
ANXA6,
SLEB4,
P2RX7,
PDCD1,
NOS3,
CXCR4,
SIRT1,
ACTB,
MYD88,
MTHFR,
PPARD,
PADI4,
PTPA,
ADAM10,
MMP9,
PRKAR1A,
CXCL13,
CD274,
VCAM1,
PRKCB,
SH2D1A,
LGALS9,
LGALS3,
LEP,
IL21R,
TNFSF4,
TRPM2,
MIR125A,
CXADR,
NR1I3,
CD40,
XRCC6,
CD69,
CD72,
APOL1,
VSIR,
NEAT1,
HMGB1,
CDR1,
SYK,
IL27,
IL34,
SSB,
ETS1,
EMB,
SRCIN1,
FAM167A,
RBM45,
UBASH3B,
SLAMF1,
EGFR,
MBD2,
TNFSF13,
SLAMF6,
CTNNB1,
SPG7,
GATA3,
KRT20,
CXCR3,
IGAN1,
REN,
RPS19,
CD38,
CD19,
TGFB3,
STING1,
MS4A1,
HDAC9,
AHSA1,
FCGR2C,
IER3,
SPATA2,
SH2B2,
ATG12,
DCTN6,
EIF2AK3,
TNFSF12,
TNFSF9,
AIMP2,
TNFSF15,
C1QL1,
HNRNPDL,
LILRB4,
MBTPS1,
LILRA3,
H4C5,
CORO1A,
PADI2,
H4C13,
PSME3,
PROCR,
XPR1,
DGAT1,
H4C11,
H4C12,
TRIM38,
NR0B2,
MAEA,
H4C6,
ZNRD2,
H4C3,
OASL,
H4C8,
ATG5,
H4C2,
H4C1,
MACROH2A1,
BECN1,
GRAP2,
CD163,
H4C14,
ANP32B,
H4C9,
KLK4,
TAM,
TNIP1,
H4C4,
NAT2,
SYNPO,
DNER,
VGLL3,
GSTK1,
TICAM2,
H3C15,
RSPO1,
IFNL3,
SGMS1,
TIGIT,
CENPV,
BTLA,
IL23R,
DOCK11,
SLCO6A1,
H3C14,
H4-16,
CTHRC1,
TNFRSF13C,
CGAS,
NLRP3,
IL17F,
PRRT2,
LBX1-AS1,
MIR142,
MIR145,
MIR633,
LOC102723971,
ERVW-4,
ERVK-20,
KLRC4-KLRK1,
RPL17-C18orf32,
TMED7-TICAM2,
H3C9P,
SIGLEC14,
CCR2,
H3C13,
MIR150,
MIR485,
H4C15,
WG,
TNFSF12-TNFSF13,
MIR17HG,
MIR29B2,
MIR29B1,
MIR23B,
MIR224,
ORMDL3,
IL33,
KLRK1,
ELOF1,
CD244,
IL23A,
NT5C3A,
TMED7,
DUOX2,
CD209,
ERVW-1,
TBX21,
PDCD4,
PHGDH,
POLDIP2,
RNF19A,
CABIN1,
TNFRSF13B,
BRD4,
NBEAL2,
KDM6B,
ZNF423,
DKK1,
ATF6,
PLA2R1,
DUOX1,
RIPK4,
VIP,
HIVEP3,
LBH,
CD276,
VTCN1,
WNK1,
IL25,
GORASP1,
ERVK-6,
BACH2,
RFH1,
HAMP,
LARP6,
PHRF1,
MRTFA,
SCYL1,
SLC12A9,
BDH2,
SPHK2,
IFNK,
APOM,
CHST12,
VWF,
PTPRC,
VIM,
DUSP4,
F10,
F2,
ERN1,
ERBB2,
EPO,
EPHX2,
ELF1,
EIF4EBP1,
EGR2,
EFNA2,
TSC22D3,
FCER1G,
ATN1,
ARID3A,
DNMT3B,
DNMT3A,
DNASE1,
DLAT,
CX3CR1,
CTBP2,
CSF3R,
CSF1,
F12,
FCN2,
EZR,
HIF1A,
IFNAR2,
IFI27,
HSPG2,
HSPA5,
HSPA4,
HNRNPC,
HMGN2,
HLA-H,
HLA-DQA1,
HLA-C,
HGF,
FOXC1,
CFHR1,
CFH,
H1-0,
GSTP1,
GRIN2A,
GRN,
GPER1,
GPI,
GFI1,
IFI6,
MAPK14,
CRK,
CRH,
KLK3,
CAMP,
C4B,
C1QC,
TSPO,
BST2,
BGN,
ATF3,
SERPINC1,
ABCC6,
FAS,
APOE,
CREBBP,
ANXA2,
AMELX,
ABCD1,
ALB,
AKT1,
AGER,
PARP1,
ADD2,
ACP5,
ACR,
CAST,
CASP6,
CASP8,
CASP9,
COX8A,
CCR5,
CHRM3,
AKR1C4,
CD52,
CDKN1A,
CDH13,
CDK1,
CD48,
ENTPD1,
CD36,
CD80,
CD8B,
CD247,
CD3G,
CD2,
CD1D,
CD1A,
CBL,
RUNX1T1,
CAT,
IFNB1,
IFNR,
IL1RN,
RPL17,
SH3BP2,
SRSF1,
SELP,
SDC2,
CX3CL1,
CCL14,
CCL3L1,
SERPINB3,
S100B,
RPS6,
TRIM27,
PRKCD,
RELB,
RELA,
PTX3,
ABCA1,
PTPN11,
PTPN6,
PTGS2,
PTGS1,
PSMD9,
MASP1,
SLC4A1,
SIGLEC1,
SNCA,
SNRNP70,
VDR,
UMOD,
TYK2,
TRPC6,
TRAF6,
TRAF2,
HSP90B1,
TPO,
TP53,
TNFRSF1B,
TNFAIP3,
TIMP3,
THAS,
TG,
ZEB1,
ADAM17,
SYT1,
SUV39H1,
SRI,
SNRPB,
SNRPA,
MAP2K1,
PRKCA,
IL7R,
LCT,
MMP11,
MMP2,
AFF1,
CIITA,
MFGE8,
CD46,
MCL1,
CD180,
LY6E,
LDLR,
LCN2,
SRGN,
LBR,
LAG3,
KIR2DL4,
KIF5A,
ITGAX,
ITGAE,
IRF6,
TNFRSF9,
IL16,
IL15,
MNAT1,
MPL,
MPO,
MRC1,
PPARG,
PON1,
SERPINA1,
PGK1,
PF4,
PECAM1,
PDE7A,
PCNA,
PC,
PAK3,
OCA2,
NT5E,
PNP,
NOTCH1,
NHS,
NFKB1,
NF1,
NEDD9,
NCL,
COX1,
MSH5,
H3P23
Drugs
Registered!
A rare form of chronic cutaneous lupus erythematosus characterized by erythematous, scaly papules and plaques preferentially occurring on sun-exposed skin areas (scalp, face, and ears) and exhibiting follicular plugging, pigmentary changes, and central atrophy, scarring, and telangiectasia. Skin biopsy shows a perivascular and periadnexal lymphocytic infiltrate and involvement of the dermoepidermal junction with thickening of the basement membrane and vacuolar degeneration of the basal cells. A small percentage of patients may develop systemic lupus erythematosus.