Prostate Cancer, Hereditary, 3
For a general discussion of hereditary prostate cancer, see 176807.
MappingBerry et al. (2000) found evidence for a prostate cancer susceptibility locus on 20q13, which they called HPC20, particularly in families having fewer than 5 affected members (multipoint nonparametric linkage score (NPL) 3.22, p = 0.00079), a later average age of diagnosis (multipoint NPL 3.40, p = 0.0006), and no male-to-male transmission (multipoint NPL 3.94, p = 0.00007). The group of 19 patients having all 3 of these characteristics had a multipoint NPL of 3.69 (p = 0.0001).
To further assess the potential contribution of a 20q13 locus to prostate cancer susceptibility, Bock et al. (2001) studied 172 unrelated families affected by prostate cancer, using 17 polymorphic markers across a 98.5-cM segment of chromosome 20 that contains the candidate region. The strongest evidence for linkage was seen in a subset of 16 black families (lod 0.86), but in general the linkage study did not provide statistically significant support for the existence of a prostate cancer-susceptibility locus at 20q13.
Zheng et al. (2001) found elevated NPL scores in a study of 159 hereditary prostate cancer families and higher NPL scores in subsets of families with a later age of diagnosis (65 years or later; NPL 1.94), fewer than 5 affected family members (NPL 1.74), or no male-to-male disease transmission (NPL 1.01). The region with positive linkage scores spanned approximately 60 cM from 20pter to 20q11 in these subsets of families.