Clear Cell Renal Cell Carcinoma
Watchlist
Retrieved
2021-01-18
Source
Trials
—
Genes
FLCN,
VHL,
HNF1A,
SETD2,
PBRM1,
OGG1,
BAP1,
MTOR,
KDM5C,
MET,
TSC1,
HNF1B,
GSTM1,
PIK3CA,
ERBB2,
TFE3,
GJB1,
EPAS1,
ALK,
TP53,
MITF,
TSC2,
IL6,
ADIPOQ,
KDR,
PTGS2,
PTEN,
GSTT1,
TGM2,
GSTP1
FLCN,
VHL,
HNF1A,
SETD2,
PBRM1,
OGG1,
BAP1,
MTOR,
KDM5C,
MET,
TSC1,
HNF1B,
GSTM1,
PIK3CA,
ERBB2,
TFE3,
GJB1,
EPAS1,
ALK,
TP53,
MITF,
TSC2,
IL6,
ADIPOQ,
KDR,
PTGS2,
PTEN,
GSTT1,
TGM2,
GSTP1,
ELOC,
TNFSF10,
PRCC,
SLC2A1,
MAPK8,
FLT1,
DAPK1,
KDM6A,
IL13,
BIRC7,
ARID1A,
KRT7,
APAF1,
PVALB,
ATM,
POMC,
APRT,
SFRP2,
L1CAM,
HSPB1,
ANXA4,
KEAP1,
RELA,
IL4R,
TEK,
TMEM127,
KRT8,
RNF139,
BIRC5,
ALOX5,
ALDH1A1,
FLT4,
SOD2,
PAK1,
UNC5C,
NF2,
SCARB1,
DCLK3,
IFNA2,
NDRG1,
PEBP1,
HSPD1,
CASP2,
MUC4,
CRABP1,
PGK1,
BTG3,
SLC49A4,
PRAME,
CPQ,
HSPA9,
ZNF765,
CUL7,
WNK3,
NAV3,
CDK15,
IL6R,
CARD11,
ZNF536,
SHANK1,
KCNMA1,
LRP1B,
CAPG,
AHNAK,
MYO3A,
KRT32,
CRYAB,
INPP4B,
MERTK,
CSMD3,
FAM111B,
PDXDC1,
PNKD,
PIDD1,
LMAN2L,
LRRK2,
ERN1,
FPGT,
CNN2,
YIPF3,
CTSB,
SYNE2,
ASB15,
DNHD1,
GRB7,
CTSD,
MSGN1,
FAAH2,
CILK1,
TET2,
AP5M1,
AKAP13,
RIOK2,
FMN2,
HARS1,
EEF2,
ZNF804A,
NLRP12,
OR4C13,
VMO1,
SPTBN4,
RPL14,
LDHB,
BMPR1A,
MLLT10,
M6PR,
SLC5A3,
ALOX12B,
ACY1,
BRD3,
ALAD,
RYR1,
PDHB,
ROR1,
ACHE,
BCHE,
TAGLN2,
CRADD,
CHEK2,
NOD2,
MALAT1,
CCND1,
MME,
PDCD1,
MDM2,
VDR,
HIF1A,
HNF1A-AS1,
AXL,
CRP,
HLA-G,
VEGFA,
RASSF1,
MMP9,
FH,
MMP2,
STAT3,
MYC,
CD274,
SMUG1,
TGFA,
MPRIP,
TBC1D9,
TGFB1,
AR,
MIR200C,
TNF,
SMIM4,
PCNA,
BCL2,
CDKN2A,
AKT1,
FOLH1,
VIM,
MIR21,
PIK3CB,
PIK3CD,
IL10,
MIR155,
MIR210,
CTLA4,
SDHB,
TFEB,
CTNNB1,
EPO,
CASP3,
EGFR,
EGF,
CA9,
IL4,
PIK3CG,
CXCR4,
IFNG,
IFNA13,
EZH2,
ABCB1,
LARP6,
CD44,
MIR126,
IL2,
IFNA1,
IGF1,
MIR204,
PTHLH,
TERT,
PAX8,
FN1,
ELAVL2,
MIR141,
MIR30A,
FHIT,
CSF2,
ESR1,
MIR34A,
XRCC1,
PRKN,
PAX2,
ESR2,
MUL1,
NOTCH1,
HAVCR1,
DNMT1,
CCK,
MIR429,
KIT,
CASP8,
COX2,
CXCL8,
MIR10B,
DKK3,
ABCG2,
MIR221,
HPGDS,
MIR145,
COL18A1,
PDCD1LG2,
CCL2,
CXCL12,
JAK2,
MIR206,
MIR205,
NDRG2,
MAPK1,
PROM1,
MTCO2P12,
IL1B,
SFRP1,
HOTAIR,
ALB,
NFE2L2,
MIR451A,
SPP1,
SLCO6A1,
TGFBI,
GSK3B,
HGF,
CBLL2,
GSTK1,
YAP1,
HLA-A,
SPOP,
PVT1,
NFKB1,
KRAS,
IGF1R,
SPHK1,
E2F1,
MAPK3,
ZEB2,
ROCK1,
AMACR,
MCL1,
EIF4EBP1,
SMARCA1,
PPARG,
FOXM1,
EPHA3,
PECAM1,
SMAD4,
TIMP1,
PKM,
TIMP2,
SLC16A4,
SLC16A3,
HNF4A,
MMP1,
SARDH,
H3P10,
CAV1,
CDH1,
CLU,
PARP1,
ACTB,
CD38,
MIR122,
CDKN1A,
MIR106B,
HAVCR2,
CD70,
BSG,
MLH1,
MIR30C2,
MIR200A,
LDHA,
MST1,
LILRB1,
HMGB1,
CIB1,
EPHB2,
TWIST1,
HSPA5,
MTHFR,
FOXO1,
TUG1,
LEP,
MIR224,
TCHP,
SMAD2,
HMGA2,
LOXL2,
FOXP3,
MIR378A,
EIF4E,
MUC1,
FAS,
ITPR2,
BRD4,
PRKCA,
IL18,
DAB2IP,
GABPA,
PLIN2,
SDHA,
MIR183,
SDHD,
TMED7-TICAM2,
PDGFRB,
SERPINE1,
CDKN1B,
SOX2,
YBX1,
SOX4,
CXCR2,
TMED7,
BHD,
ACKR3,
TICAM2,
IGFBP3,
RUNX3,
MIR15A,
MIR144,
RBX1,
ASPSCR1,
CD34,
NEAT1,
GNAS,
KDM6B,
DKK1,
HEPACAM,
HDAC1,
SDS,
CDK4,
CDH6,
IFNB1,
HLA-C,
DCTN6,
ITGA5,
SPINT2,
ZNRD2,
CDK1,
IFI27,
KHDRBS1,
LEPR,
MIR182,
NNMT,
MIR338,
MT1G,
TGFBR1,
XIAP,
APEH,
TAP1,
NEDD9,
AURKA,
MIR497,
SORD,
SOCS3,
SMARCB1,
SDHC,
MICA,
S100A9,
PPARA,
PRKAA1,
PRKAB1,
MAP2K1,
H3P23,
THRB,
MSH2,
TIMP3,
MMP3,
KISS1,
MBD2,
SQSTM1,
MIR195,
CA12,
KRT19,
GATA3,
LGALS3,
MIR203A,
BRCA1,
MIR22,
MIR222,
WT1,
MCAM,
EZR,
MIR27A,
B2M,
MIR29A,
MIR30C1,
MYOF,
PSMD9,
RAB25,
GAS5,
CYP1A1,
ZC3H12A,
EDN1,
EDNRB,
SLC12A9,
XRCC6,
CYP1B1,
KLF6,
DEFB1,
FABP7,
MAP1LC3B,
ACE,
ANGPTL4,
EN2,
EPOR,
HILPDA,
SNAI2,
ICAM1,
SLC22A2,
TCF4,
ERBB4,
MIR590,
BMP6,
MEG3,
PGF,
UCA1,
CXCR1,
CD24,
ADIPOR1,
CIP2A,
ENG,
BNIP3,
KLK3,
MIR125A,
MAGEA6,
SMYD2,
TCF21,
PDK1,
VTCN1,
MIR106A,
ARHGAP24,
TCF7L2,
DUXAP8,
FGF2,
HDAC9,
RBM10,
CD80,
MIR223,
PCDH8,
PFN1,
FGFR3,
ILK,
BRAF,
FABP5,
CAPNS1,
ANGPT1,
ANGPT2,
FBXW7,
MIR185,
APLN,
LGALS1,
NME1,
SST,
BECN1,
EGLN1,
MIR199B,
MIR19A,
JADE1,
STK11,
TESC,
MIR200B,
TNFRSF10B,
EWSR1,
CCN3,
CD82,
SNAI1,
L2HGDH,
CUL2,
MIR17,
LCN2,
CAV2,
CXCL10,
ALPP,
NUCB2,
ROR2,
MIR508,
DCTN4,
MIB1,
CBFA2T2,
ITGB1,
GDE1,
MIR181A2,
LATS1,
MED15,
SART1,
CASR,
CD68,
ABCC1,
CD74,
CDCP1,
CMTM4,
PRKAA2,
REN,
MKI67,
TGFB2,
KLF8,
PPBP,
CDKN2B,
GSTM2,
CISH,
MIR29C,
POU2F2,
GTF2H1,
SFPQ,
FAM107A,
FSTL1,
TYMS,
S100A1,
WNK1,
GPT,
PMS2,
MIR99A,
LAT,
PTBP1,
UCN3,
ABCC2,
CMAS,
PTK2,
TLR1,
NUP62,
ACSS2,
TPM1,
MT1E,
ASS1,
BBC3,
SIRT1,
MOK,
BRK1,
TGFBR2,
GATA5,
TRPM3,
CASC2,
ESM1,
VEGFC,
MIR384,
LUCAT1,
SIX2,
MAP3K8,
HOTTIP,
POSTN,
MIR425,
ADM,
MTDH,
HMOX1,
ATG7,
UHRF1,
CTSK,
NDUFA4L2,
TFAP2A,
FOXO3,
LINC01194,
CLDN7,
PLAU,
GOLPH3,
SCD,
HLA-DRB1,
UCP1,
EGLN3,
MFAP1,
CDK2,
MIR29B2,
RALBP1,
COL11A2,
PLK1,
MIR29B1,
SATB1,
VCAM1,
VCL,
MIR373,
ADAM17,
ELOB,
THBS1,
TFRC,
RETN,
MIR452,
TAZ,
SYT1,
RNF20,
MAP3K7,
ZEB1,
TRBV20OR9-2,
TGFBR3,
GRHL2,
TAP2,
MIR372,
MIR363,
WLS,
MUC13,
ESRP2,
CYTOR,
STK3,
GORASP1,
RPL17,
RPS6,
RPL17-C18orf32,
RBM14-RBM4,
S100A4,
S100A6,
S100A8,
S100A10,
RAB4B-EGLN2,
S100A11,
S100B,
CCL18,
CCL21,
SAV1,
CXCL16,
SELE,
BCL2L2-PABPN1,
RNASE3,
MIR489,
LOC110013312,
FSD1,
H3P8,
LNCRNA-ATB,
PTPRG,
BHLHE41,
LNCARSR,
LOC110806263,
GHET1,
HMGN5,
PANDAR,
RAC1,
RAF1,
REG1A,
FRTS1,
COMETT,
MARCKSL1,
MUC3B,
MIR1233-1,
SET,
SPAG4,
SMN1,
MIR486-1,
SMN2,
SNCA,
FSCN1,
MIR509-1,
SOX9,
SPARC,
KLLN,
TP73-AS1,
SREBF1,
ST14,
MIR499A,
STAT1,
MIR490,
STC1,
KLHL1,
MIR411,
SLPI,
SLC16A1,
SYCE1L,
MIR543,
MIR877,
SFRP4,
SH3BP2,
ST3GAL4,
VTRNA2-1,
SLC5A2,
TEC,
MIR663A,
MIR630,
SLC6A3,
SLC12A3,
MIR625,
SLC15A1,
CRNDE,
MIR212,
SLC50A1,
CXCR6,
MCRS1,
KMT5A,
HOXB13,
SPTLC1,
CXCL13,
SLC34A2,
TXNIP,
CRB3,
MCTS1,
DLEC1,
NES,
FNIP1,
MTHFD2,
CCL27,
HPSE,
PGRMC1,
EGLN2,
LAMTOR2,
RBM14,
MIRLET7D,
TFCP2L1,
DLC1,
AKT3,
PTPRU,
NOX4,
G3BP1,
PSME3,
OBP2A,
WNT3A,
MIR10A,
COL23A1,
TRIM13,
MIR100,
SENP1,
FLOT1,
CDK2AP2,
PAK4,
AKR1A1,
IRF9,
PPARGC1A,
MCAT,
SUB1,
EPB41L3,
KANK1,
ARC,
SATB2,
PPP1R13B,
SIRT3,
CACYBP,
MUC17,
SEC14L2,
PACRG,
OSR1,
SNHG1,
PSMB9,
PLA2G15,
QPCT,
RWDD3,
ATRNL1,
INTS1,
DKK4,
PRRT2,
ANGPTL3,
NCOA6,
FERMT2,
PDLIM3,
PCDH17,
RPP14,
HHLA2,
MAGEA2B,
WIF1,
CADM2,
PDCD4,
SLC39A1,
AGO2,
SKA1,
RASSF6,
VASH1,
SLFN5,
DKK2,
SMG1,
SCO2,
SPATA2,
MIR337,
FSD1L,
MIR217,
MIR216A,
MIR215,
SLC7A5,
TCL6,
MIR211,
KDM5D,
SOX7,
RGS5,
MIR130B,
PPM1D,
BHLHE40,
KAT8,
EIF3D,
NAT10,
CEP55,
RIPK1,
TRPM7,
LAP,
CD276,
HIF1AN,
WNT10A,
MIR335,
MIR133B,
TOP2A,
MIR96,
MIR31,
TP73,
TPM3,
KDM3A,
NR2C2,
TRPC6,
MIR30B,
UCHL1,
ASRGL1,
MIR28,
PPP1R2C,
MIR23B,
MIR23A,
MIR20A,
TNFRSF10A,
MIR19B1,
PTTG1,
KLF4,
SLIT2,
KL,
QKI,
ING4,
AIM2,
GAL3ST1,
PCLAF,
APH1A,
MAML1,
MIR150,
MIR149,
MIR146A,
SNHG12,
MIR143,
MIR142,
MIR137,
PIWIL1,
MAGI1,
NRP2,
FTO,
NRP1,
ACCS,
RIOX2,
MIR193A,
CFLAR,
MIR191,
NR1I2,
DLL4,
NUDCD1,
MIR184,
MPC1,
HSPB3,
SF3B6,
SPAG9,
CLDN8,
EBAG9,
DCLK1,
AURKB,
BTG2,
PSMB8,
CD40,
CD47,
CD151,
CDC20,
CDH3,
MAGEA2,
SMAD3,
EPCAM,
LRPAP1,
CDH15,
LOX,
CDK6,
CDK7,
LHX1,
CEBPB,
LDLR,
CHI3L1,
LAMA4,
LAG3,
KIF22,
CMA1,
CCR4,
KLK1,
ITGA7,
COL5A1,
COX8A,
CREB1,
CRH,
CD40LG,
MDM4,
ANXA2,
CCNB1,
ANXA5,
APC,
NPTX2,
APEX1,
APOE,
NONO,
FASLG,
NFKB2,
MYCN,
ATHS,
ATP1A1,
ATP1B1,
MUC3A,
BAX,
BCL2L2,
MRC1,
BMP2,
BST2,
C1QBP,
MIP,
DDR1,
CXCL9,
CALR,
CASP9,
MGMT,
RUNX1,
MAP3K5,
CRHBP,
IL16,
IL13RA2,
IL11,
EEF1A1,
EGR1,
EPHA2,
CXCR3,
GOT2,
ENO1,
ENO2,
GLS,
EP300,
ERCC2,
GC,
ETFA,
ETS1,
GAS6,
GAD1,
G6PD,
G6PC,
F2R,
F2RL1,
FOS,
F3,
F12,
PTK2B,
FGFR2,
FCGR3B,
FCGR3A,
FBN2,
GRP,
EDNRA,
GSTM3,
HSPA4,
IL2RA,
IL1A,
IKBKB,
CCN1,
IGFBP7,
CSF1R,
IFNAR2,
VCAN,
CST3,
IRF8,
CYP2D6,
HSPB2,
HSPA2,
TYMP,
HSPA1B,
HSPA1A,
DAG1,
NQO1,
HOXA6,
DIO1,
DKC1,
HNRNPA2B1,
NR4A1,
HK2,
DUSP9,
E2F3,
P2RY1,
FBP1,
AGT,
AGER,
POU5F1,
ENPP2,
ALOX15,
PDPK1,
MAPK7,
POLR2A,
PPIA,
PLG,
ACVRL1,
ALOX12,
JAG1,
ADAM10,
MAP2K7,
PIK3R1,
SLC25A3,
ADRA1A,
PDZK1,
PIM1,
AHR,
PRKCB,
PML,
DES,
GNPTAB,
LINC01234,
CDC73,
SLC52A2,
DFFA,
DNASE1L3,
OTUD6B-AS1,
ADIPOR2,
DDC,
NANOG,
ADORA1,
ADH7,
DACH1,
MIR3133,
MIR1260B,
DHDDS,
LINC01094,
LPCAT1,
RASL11B,
AGMAT,
ZNF419,
RIOX1,
SAP30L,
RTL10,
DCN,
NDNF,
DNMT3A,
DPP4,
ZSCAN18,
LGR6,
COP1,
ERAP2,
MELTF-AS1,
DVL2,
FKBP10,
E2F2,
ADAMTS9-AS2,
SCPEP1,
MFSD14A,
ACE2,
HIVEP3,
LY6G6D,
ECE1,
CTDSP1,
NFE4,
ADAM8,
HIF3A,
DSG2,
OCLN,
MRPL41,
DNMT3B,
FTX,
DRD1,
THORLNC,
DRD2,
ATN1,
ACD,
CENPH,
COPS7B,
RCAN1,
USP46,
DDX31,
TNS3,
GIHCG,
ATPAF1,
SMURF2,
CYP27B1,
PDGFD,
CYP24A1,
KISS1R,
HAPLN1,
CRYBA4,
C19orf48,
PYROXD2,
AFAP1-AS1,
CRYGD,
SPZ1,
NT5C1A,
DOT1L,
MAP1LC3A,
MAK16,
LINC00887,
FILNC1,
SNORD35B,
ADRA2B,
ACSS1,
ORAI1,
CRK,
CORO6,
CRHR2,
CPOX,
CRABP2,
IGFN1,
IL33,
MED30,
EGOT,
LMLN,
ATF2,
SSH2,
SNORD14E,
SNORD14D,
SNORD14C,
SNORD14B,
DNM1P35,
UBASH3B,
TRAP,
CRYZ,
CYP4B1,
CTNNA1,
TRIM8,
TXNDC5,
MIR1291,
SLC35G2,
MIR1236,
CTAG1B,
CCN2,
CXXC4,
AKT1S1,
CXADR,
HES4,
FBXO11,
RNF34,
CYLD,
MIR1290,
CYP3A5,
CSNK2A1,
VMP1,
SH3BGRL3,
CSNK1E,
RPAIN,
MAPK14,
SETD3,
MINDY4,
NLRC5,
CSF1,
MAGT1,
TMPRSS13,
CCDC8,
MIR1294,
SETDB2,
SLC25A18,
SESN2,
CSF3,
RASSF5,
HAMP,
AMFR,
TRIB3,
PPP1R12C,
LINC01885,
ANKHD1,
EZH1,
ASIC2,
ERCC6L,
F2,
RNF111,
XAF1,
CMTM6,
TMED9,
UGT1A1,
LNCSRLR,
ACAT1,
DDIT4,
KRT20,
GFOD1,
CASZ1,
SARS2,
TREM2,
TPTEP2-CSNK1E,
LAPTM4B,
ESRRA,
RNF121,
ESRRB,
IMP3,
PACC1,
ESRRG,
SNHG14,
RNF125,
TMEM45A,
OXR1,
ETS2,
IRAIN,
ETV1,
PINX1,
SDHAF2,
SOX18,
F2RL2,
ECHS1,
LEF1,
SLC22A17,
TLR7,
CLEC1B,
NUSAP1,
AADAC,
HSPA14,
HAO2,
FBLN1,
TNFRSF12A,
EGFL7,
SDF4,
FBN1,
CHCHD2,
SERPINA3,
H3P42,
H3P47,
PLAC8,
COMMD10,
ACADM,
NUB1,
CDHR5,
IL20RB,
MNS16A,
IL17D,
RSF1,
WWOX,
RAB23,
ACACA,
SFMBT1,
FABP1,
TRIM33,
ACSL1,
ABL2,
IL23A,
SIRT6,
HIKESHI,
HJURP,
ERG,
ERCC4,
CIAPIN1,
ZMIZ1,
SMURF1,
RTN4,
MAN1C1,
CHMP1B,
EFNA1,
TIGAR,
ADAMTS9,
ADA,
ACTG2,
CHPT1,
PRDM9,
FAM20C,
EIF4B,
PNO1,
ACTG1,
SLC39A10,
CEMIP,
SAGE1,
ARRDC3,
ECT2,
EP400,
S1PR1,
CP,
ZNF492,
ERV3-2,
FNIP2,
SEMA6A,
DANCR,
TRIM52-AS1,
MTA3,
LOC100507703,
PHC1,
SCYL1,
RAB22A,
CLTRN,
ELANE,
ELF5,
ELK1,
DOK4,
IATPR,
PAG1,
EPHA1,
EPHA5,
CCAR1,
EPHB4,
ASF1B,
ERBB3,
ELN,
NLRP2,
ACLY,
PNRC2,
SMPD4,
SUPT20H,
RBM38,
KCNQ1DN,
GABRQ,
NPTN-IT1,
ZNF395,
ENPEP,
PANX2,
TWNK,
DIABLO,
SPRY4-IT1,
PPAN,
METTL3,
TRPV5,
PARD3,
MARK2,
SUSD2,
PDGFC,
MYDGF,
ACTA2,
SULF2,
ACR,
EGFR-AS1,
COX5B,
WDR20,
MIR196A2,
C5AR1,
VPS51,
CA4,
CA8,
MIR199A2,
MIR199A1,
MIR198,
MIR196A1,
KLF5,
MIR556,
MIR572,
CALCR,
MIR192,
MIR584,
MIR186,
CAPN1,
ALDOB,
PPAN-P2RY11,
CASP10,
CXCR5,
CXADRP1,
OPN1SW,
BDNF,
BGLAP,
CEACAM1,
MIR539,
BIK,
BNC1,
BRS3,
BMI1,
BMP1,
LINC00488,
BMP4,
BMP7,
BMPR1B,
BMX,
CAPN2,
MIR588,
TIMD4,
ENTPD1,
CD19,
MIR129-2,
MS4A1,
CD27,
MIR124-3,
CD28,
CD36,
MIR107,
MIR134,
MIR622,
ALDH9A1,
MIRLET7I,
MIRLET7F2,
MIRLET7C,
MIRLET7B,
ALDH3B1,
MIR132,
MIR136,
CAT,
CBS,
RUNX2,
MIR15B,
RUNX1T1,
MIR154,
CBL,
SERPINH1,
MIR148A,
ALDOA,
CD14,
MIR599,
CCNC,
CCNE1,
CCT,
MIR613,
CD1D,
MIR138-1,
BCL2A1,
BBS2,
MIR24-1,
MIR381,
H4C15,
POU5F1P3,
DUXAP9,
SMIM5,
APOH,
AQP1,
MIR383,
H3P16,
APLP2,
AQP4,
MIR377,
MIR376A1,
MIR375,
AQP9,
ARG1,
MIR367,
MIR362,
MIR20B,
MIR24-2,
MIR510,
MIR502,
MIR501,
ANXA1,
MIR498,
AMBP,
MIR193B,
MIR495,
MIR492,
SNHG6,
MIR146B,
ALPI,
ANXA6,
MIR488,
MIR409,
MIR455,
POTEM,
ARG2,
RHOB,
ARHGDIB,
ATP5F1A,
MIR32,
LINC00461,
MIR30E,
MIR30D,
ATIC,
IGFL2-AS1,
ATP2B1,
ATP5MC1,
MIR328,
POU5F1P4,
ATP5MC2,
MIR299,
AVP,
AZU1,
MIR26B,
MIR25,
ATF4,
PIK3CD-AS1,
MIR34B,
MIR34C,
MIR302C,
ARNT,
XRCC6P5,
GPR166P,
ZFAS1,
VN1R17P,
ARR3,
POTEKP,
MIAT,
TNFSF12-TNFSF13,
MIR17HG,
MIR99B,
ARRB2,
STS,
MIR93,
LINC00997,
LINC00511,
FENDRR,
CCR3,
AGTR1,
PNCK,
RALYL,
UNC5D,
MIR216B,
GPR151,
UBE2QL1,
ZFP42,
SELENOM,
MIR942,
RBM45,
TSACC,
MIR708,
ATP6V1G3,
B3GALT6,
PLK5,
CLN3,
APLNR,
CHEK1,
PWAR1,
BTLA,
SYT6,
CDKN2B-AS1,
DIRAS1,
KIF18B,
MGAT5B,
AKT2,
CHI3L2,
CLIC1,
LAYN,
PIWIL4,
FRMPD2,
CIRBP,
FCER1G,
KRT72,
UBE2F,
SLC43A2,
CANT1,
H4-16,
TP53INP1,
MED8,
MIR885,
COL6A3,
COL11A1,
COL15A1,
MYL12B,
SLC31A1,
HTRA3,
RHEBL1,
MUC16,
TTYH2,
DNER,
ARRDC1,
MIR505,
MTG1,
COX6B1,
AHNAK2,
AZIN2,
TRIM9,
COL4A3,
TMEM52B,
CNR2,
CYP2R1,
LARGE2,
GSTO2,
TWIST2,
MRGPRX4,
MRGPRX3,
CMTM5,
LRRC3B,
CTHRC1,
COL3A1,
MIR155HG,
MAL2,
NLRP3,
FGD5,
SPINK13,
ALKAL1,
KLHL35,
SNHG15,
ABCD1,
LYPD5,
MAGED4,
CAVIN1,
CDH9,
CDH13,
MAGEA9B,
DLX6-AS1,
NBAT1,
CDH16,
CDK5,
ASPM,
MRGPRX1,
NCR3,
CCR2,
ATG9B,
TRIM59,
ABCA13,
MIR645,
LINC01138,
TMIGD1,
CDC25B,
SLC16A12,
CDC42,
CDH2,
NDUFS7,
CDH5,
RAB37,
ACTBL2,
GPR149,
MIR646,
MIR660,
CDH8,
TREML3P,
GADL1,
CRPPA,
RICTOR,
STXBP4,
DNAJB8,
CADM4,
LDHD,
DNAJB1P1,
ADAMTS18,
FUT11,
GLIS3,
MIR766,
OXER1,
IL27,
CENPE,
CETN1,
RCC1,
ASS1P3,
SPAAR,
TMEM213,
AMOT,
MIR671,
NUDT17,
TXLNA,
TET3,
CTAG1A,
SCUBE3,
GPRC6A,
HOXA11-AS,
KDM1B,
MARCHF8,
CDKN1C,
CDO1,
UNC5B,
NRK,
PRSS55,
C4orf46,
SLC39A11,
CENPX,
CEACAM5,
SRXN1,
FLT3,
GAL,
COL14A1,
MAP3K3,
VBP1,
VASP,
UTY,
USP1,
UQCRFS1,
UQCRC1,
NR1H2,
UGT1A,
MCM5,
MGAT5,
UCN,
KITLG,
SUMO1,
TYK2,
TXNRD1,
MGP,
TUFM,
MCM6,
VEGFB,
TSG101,
WNT2,
XRCC3,
MAX,
XPO1,
XPNPEP2,
XPNPEP1,
XIST,
MB,
WNT11,
WNT1,
MCM4,
NSD2,
LAT2,
VTN,
TRPV1,
VIP,
MCC,
MCM2,
MCM3,
TTK,
CIITA,
NDUFA13,
MT1A,
MMP14,
ALDH6A1,
TIE1,
TIAM1,
KLF10,
MSMB,
MSN,
MST1R,
MT1H,
TLR4,
MT1M,
MTAP,
COX1,
MTHFD1,
ND3,
MTNR1A,
MTRR,
NR2F2,
MMP13,
TSPAN7,
MIF,
FOXO4,
TRPC4,
TRAF6,
TRAF1,
CRISP2,
TPT1,
MAP3K9,
KMT2A,
TPD52,
TP53BP2,
TM7SF2,
NR3C2,
MMP7,
TNFRSF1B,
TNFRSF1A,
TNFAIP6,
MMP11,
CLEC3B,
TMSB4X,
YY1,
ZFX,
ZNF148,
CUL1,
CDC14B,
LGALS9,
APOL1,
COPS3,
YBX3,
SLC43A1,
LIFR,
OGT,
LIG4,
USO1,
CAVIN2,
NR0B2,
SNHG3,
ULK1,
LIPA,
LMNB1,
SPARCL1,
H4C14,
MKNK1,
HSD17B6,
ZBTB17,
SLC4A4,
TNFRSF6B,
ADAM9,
LCN1,
TNFSF12,
TNFSF13,
LDHC,
ABCC3,
LETM1,
LGALS3BP,
LGALS8,
EIF3C,
EIF3B,
IRS2,
DYNLL1,
SOCS1,
NCOA1,
AKR1C3,
RTCA,
H4C13,
H4C5,
H4C2,
AIMP2,
MAD2L1,
KMT2D,
FGF23,
CUL5,
CUBN,
KAT6A,
TUSC3,
ARHGEF5,
MAGEA4,
H4C8,
MAGEA9,
ST8SIA4,
FZD5,
MAGEB2,
MAOB,
NAT2,
BSND,
PRDM2,
DPF3,
CAPRIN1,
CDR3,
LSAMP,
H4C3,
H4C11,
H4C12,
H4C6,
H4C4,
H4C1,
FZD8,
FZD7,
FZD4,
FZD1,
EOMES,
BRAP,
AXIN2,
AXIN1,
H4C9,
DYSF,
LRP2,
MUC5AC,
TERF2,
TERF1,
PON1,
SAG,
PLD2,
S100A12,
PLOD1,
PLOD2,
PMAIP1,
S100A5,
PRRX1,
RXRG,
PLD1,
RXRA,
RRM2,
RPS15A,
RPS6KB1,
POU3F2,
ROS1,
SNORD15A,
BRD2,
MAPK12,
PLCL1,
SFRP5,
PITX1,
PHF2,
SERPINA1,
SELENOW,
SEMG1,
SELP,
PIK3R2,
PIN1,
PIP,
CXCL5,
SRL,
CXCL11,
CCL22,
PITX2,
PLAGL1,
CCL17,
CCL11,
CCL7,
PLAUR,
RNF2,
PPP3CA,
RIT1,
PTPRC,
RAC2,
PRKDC,
RAB27B,
RAB27A,
PYCR1,
MAPK9,
PTPRZ1,
PTPRD,
PTPN6,
RHO,
KLK7,
KLK10,
PRTN3,
PTGS1,
PTGER4,
PSEN1,
PTCH1,
PSMB6,
PRKCZ,
PRKCE,
RAG2,
RAP1B,
RHEB,
RET,
PRF1,
PRKAR1A,
RCVRN,
RBP4,
RBP2,
RBP1,
KDM5A,
RB1,
RASA1,
RARRES1,
RARB,
RARA,
RAP2B,
RAP2A,
RAP1GAP,
PGR,
SRSF1,
TERC,
STAT6,
NELL1,
SYP,
SYCP1,
NEK1,
NELL2,
NEU1,
STIM1,
NFATC1,
STAT5B,
NEDD8,
STAT5A,
NFIA,
NFIC,
SSTR4,
NGFR,
SRPK1,
NME2,
SRC,
NEFH,
NDUFS1,
SGK1,
MYH9,
TEP1,
MMUT,
PRDX2,
MVD,
MXI1,
ZNF354A,
MYCL,
TCF3,
MYL2,
NDUFB6,
CEACAM6,
ELOA,
NBN,
NCF2,
TCEA1,
TBP,
NCL,
TAPBP,
SPINT1,
SPINK1,
SPG7,
SLC3A2,
SERPINA5,
CHMP1A,
SLC9A1,
SLC6A8,
PDC,
SLC6A1,
PDGFRA,
PDK3,
SLC2A5,
NOS1,
SLC2A4,
SLC1A5,
ENPP3,
ST3GAL2,
SHH,
FBXW4,
SHC1,
SH3GL2,
PCDHGC3,
SLC22A3,
PCBP2,
PBX1,
NOTCH3,
SP1,
SOX12,
SOX5,
NRAS,
NT5E,
NTRK1,
ORC2,
OTX1,
OVOL1,
P4HB,
PAEP,
PAFAH1B1,
SMARCA4,
SMARCA2,
PRDX1,
PAPPA,
MPDZ,
MATN4,
DLK1,
AVL9,
GPR42,
GRK5,
GPX1,
GPX3,
GRB2,
GRIA4,
KIF1B,
KDM4C,
SETD1B,
WWC1,
NR3C1,
GRM1,
GRM4,
PDZD2,
TPX2,
GRM5,
ELL2,
SIRT2,
MCF2L,
XCR1,
GIP,
GNG4,
GLI1,
GLI2,
LPAR3,
GNAI1,
GNAO1,
SRRM2,
CABIN1,
DAAM2,
TRAM1,
TRIM2,
HEY1,
ABCB10,
SF3B3,
TMED3,
GNG7,
SIRT5,
DICER1,
GPI,
PLA2R1,
MMRN1,
ZHX2,
IL24,
TBC1D8,
KIF3A,
PTPRT,
HCK,
HNRNPUL1,
HELLS,
TPPP,
KLK11,
SLC27A4,
MLXIP,
HFE,
COPS5,
HGFAC,
CKAP4,
STIP1,
HIC1,
PRDX3,
HLA-B,
HAS1,
CORO1A,
WDR45,
NUDT5,
CXCL2,
CHSY1,
OIP5,
ACOT7,
GPR182,
PARK7,
PDIA3,
GSK3A,
GSN,
MSH6,
PTENP1,
GTF2H4,
MAP4K1,
BAZ1A,
GZMB,
PSIP1,
H2AX,
GPC3,
TMEFF2,
DHRS4,
PSMD10,
MYLIP,
PYCARD,
UBE2T,
FLNB,
ATAD2,
HIPK2,
COMMD5,
NOB1,
TMEM176B,
MLANA,
DLL1,
IGHV1-12,
PCLO,
SGSM3,
FRK,
STK39,
RPS6KA6,
FRZB,
FLNA,
CARD10,
SGK3,
EHD2,
FGB,
FGFR1,
F11R,
GEMIN4,
DEF6,
ATP6V0A4,
DELEC1,
SYCP3,
CD209,
GRHL1,
NOP53,
FGFR4,
PSAT1,
VEGFD,
UBIAD1,
GPSM2,
FKBP4,
FOXI1,
TOX3,
FTH1,
RBMS3,
SOSTDC1,
PRPF31,
POLDIP2,
CHD5,
GGT1,
LRIG1,
KANK2,
GH1,
GHR,
RCHY1,
FUT3,
RNF19A,
PART1,
GHRH,
GHSR,
PISD,
C3CER1,
CADM1,
RAB38,
GDF9,
DGCR5,
PHGDH,
FBXO22,
FUT4,
KDSR,
SIGLEC8,
HSPB7,
GABPB1,
B4GALNT1,
GAPDH,
DMAC2L,
GAS1,
B3GAT1,
FOXP1,
NSG1,
USP21,
GATA1,
GATA2,
GREM1,
LATS2,
GADD45G,
HLA-E,
LBP,
INSRR,
IMPA2,
NRXN3,
SLC9A3R1,
IDO1,
INSR,
TCEAL1,
CD163,
TRIP10,
IRF1,
TSIX,
MSC,
IRF5,
ISG20,
MTA2,
XPR1,
ITGA2B,
LRRFIP1,
ARHGEF2,
COX5A,
GRAP2,
KIF20B,
MAGED1,
CXCL14,
TP53I3,
SCAMP1,
TBPL1,
GDF15,
TNFRSF9,
ADAMTS1,
ADAMTS2,
NAPSA,
NTN1,
RASAL2,
FHL5,
EIF2AK3,
IL17A,
GSTO1,
FOXK2,
NCR1,
ILF3,
LPAR2,
TMSB10,
ITGA9,
KIF11,
KHK,
FOXH1,
TIMELESS,
FUBP1,
KLK2,
KLRC1,
ARHGEF7,
PER2,
KIFC1,
PCSK7,
CDK5R1,
KAT2B,
CCN4,
KPNA2,
LAIR1,
IL18R1,
LAMP2,
LASP1,
SELENBP1,
LIMD1,
NOL3,
F2RL3,
NEURL1,
ITGAE,
ITGB2,
ITGB8,
ITK,
MTA1,
RGN,
JAG2,
PKMYT1,
CLDN1,
JAK3,
PIAS2,
SLC7A6,
SLC7A7,
JUN,
KCNH2,
KCNJ1,
APOBEC3B,
WTAP,
FGL2,
HSF1,
NPC2,
HOXD3,
HP,
HRAS,
ANP32B,
RNASEH2A,
AGFG1,
HRES1,
NXF1,
RBCK1,
GPNMB,
PRMT5,
HSP90AA1,
NDC80,
RACK1,
MYL9,
DNAJB1,
NDST1,
AHSA1,
MYL12A,
NFE2L3,
EBP,
ADAM28,
HMGCR,
HMGA1,
HMMR,
HSPH1,
FOXA1,
HNRNPA1,
USP39,
TNFSF13B,
HOXC11,
GNA13,
HNRNPK,
HOXA3,
HOXA5,
IGF2BP1,
NPRL2,
HOXA11,
PDPN,
NOD1,
TUBB3,
HTC2,
TNFSF15,
GNE,
HDAC6,
SRA1,
IGFBP5,
IGFBP6,
RCE1,
NR1I3,
MED12,
GAB2,
CNPY2,
IL1RN,
RAPGEF5,
KMT2B,
IL15,
DCAF1,
UBE3C,
SDC3,
RIN1,
ABCB6,
IGFBP4,
KIF20A,
ARL4C,
IAPP,
TNIP1,
DLEU1,
STAG1,
IDH1,
SPRY2,
STX6,
PLIN3,
CTDSPL,
IDUA,
IGF2,
TSHZ1,
MBNL2,
EBI3,
IGFBP2,
NAMPT,
OPTN,
NAT1
Drugs
(R, S)-3-(bromomethyl)-3-butanol-1-yl-diphosphate,
26 base single stranded phosphodiester DNA oligonucleotide,
4-amino-5-oxo-4 (pyridinium-1-ylmethyl) proline
(R, S)-3-(bromomethyl)-3-butanol-1-yl-diphosphate,
26 base single stranded phosphodiester DNA oligonucleotide,
4-amino-5-oxo-4 (pyridinium-1-ylmethyl) proline,
Aldesleukin
(
PROLEUKIN
),
Autologous Tumor-Derived gp96 Heat Shock Protein-Peptide Complex
(
ONCOPHAGE
),
Autologous renal cell tumor vaccine,
Axitinib
(
INLYTA
),
Bevacizumab
(
Equidacent,
AVASTIN,
Aybintio,
MVASI
),
Everolimus
(
AFINITOR,
VOTUBIA
),
Genetically modified allogeneic (human) tumour cells for the expression of IL-7, GM-CSF, CD80 and CD154, in fixed combination with a DNA-based double stem loop immunomodulator (dSLIM),
Girentuximab
(
RENCAREX
),
HLA class I/II binding tumour associated peptides (ADF-APO-CCN-GUC-K67-MET-MMPMMPMUC-RGS),
Human interleukin-2 (glycosylated tetrasaccharide, glycosylated trisaccharide and nonglycosylated) (inhalation use),
Humanized anti-KSA monoclonal antibody-human interleukin-2 fusion protein,
Interferon gamma 1b
(
ACTIMMUNE,
IMUKIN
),
Iodine (131I) chimeric IgG monoclonal antibody cG250,
N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N'-(5-methyl-3-isoxazolyl) urea hydrochloride monohydrate,
Naptumomab estafenatox,
Pazopanib hydrochloride
(
VOTRIENT
),
Recombinant human interleukin-21,
Recombinant modified vaccinia Ankara expressing human 5T4,
Siltuximab
(
SYLVANT
),
Sorafenib tosylate
(
NEXAVAR
),
Sunitinib malate
(
SUTENT
),
Talactoferrinum alfa,
Temsirolimus
(
TORISEL
)
Registered!
The Clear Cell Renal Cell Carcinoma (CCRCC) is a type of renal cell carcinoma.
Genetics
Cytogenetics
- Alterations of chromosome 3p segments occurs in 70 – 90% of CCRCCs
- Inactivation of von Hippel-Lindau disease (VHL) gene by gene mutation and promoter hypermethylation
- Gain of chromosome 5q
- Loss of chromosomes 8p, 9p, and 14q
Molecular genetics
Several frequently mutated genes were discovered in CCRCC: VHL, KDM6A/UTX, SETD2, KDM5C/JARID1C and MLL2. PBRM1 is also commonly mutated in CCRCC.
Histogenesis
CCRCC is derived from the proximal convoluted tubule.
Microscopy
Generally, the cells have a clear cytoplasm, are surrounded by a distinct cell membrane and contain round and uniform nuclei.
Microscopically, CCRCCs are graded by the ISUP/WHO as follows:
- Grade 1: Inconspicuous and basophilic nucleoli at ×400 magnification
- Grade 2: Clearly visible and eosinophilic nucleoli at ×400 magnification
- Grade 3: Clearly visible nucleoli at ×100 magnification
- Grade 4: Extreme pleomorphism or rhabdoid and/or sarcomatoid morphology
Epidemiology
- Most commonly affects male patients in their sixties and seventies.
- Majority of CCRCC arise sporadically.
- Only 2 – 4% of the cases presenting as part of an inherited cancer syndrome, such as von Hippel-Lindau syndrome.
Images
Clear cell renal cell carcinoma. Macroscopy.
Clear cell renal cell carcinoma. HE, x100.
Clear cell renal cell carcinoma. Führman Grade = 1. HE, x400.
Grade 3: Arrows point at a clearly visible nucleolus