Frontonasal Dysplasia With Alar Clefts

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2019-09-22

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Omim

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Rimoin (1969) and Fox et al. (1976) described 2 sisters with an identical malformation of the nose consisting mainly of hypoplasia and coloboma of the alar cartilages. Both also showed telecanthus. The parents and other relatives were unaffected and no parental consanguinity was reported. This remains a unique observation (Gorlin, 1982).