Primary Mediastinal Large B-Cell Lymphoma
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
XPO1,
BCL6,
MAL,
JAK2,
CD274,
MYC,
MS4A1,
PDCD1LG2,
KRT20,
SOCS1,
CIITA,
PAX5,
FSCN1,
IL4,
BCL2,
GATA3,
FOXP1,
CGB8,
REL,
RPE65,
SLC22A2,
SOAT1,
STAT6,
TNFAIP3,
IL4I1,
UVRAG,
CGB5,
CHRDL2,
TCL1A,
TP63
XPO1,
BCL6,
MAL,
JAK2,
CD274,
MYC,
MS4A1,
PDCD1LG2,
KRT20,
SOCS1,
CIITA,
PAX5,
FSCN1,
IL4,
BCL2,
GATA3,
FOXP1,
CGB8,
REL,
RPE65,
SLC22A2,
SOAT1,
STAT6,
TNFAIP3,
IL4I1,
UVRAG,
CGB5,
CHRDL2,
TCL1A,
TP63,
CARD11,
AICDA,
CD83,
PIK3CG,
TCL1B,
CKAP4,
POU2F2,
AKT1,
PIK3CD,
PIK3CB,
BCL2A1,
CD19,
TNFRSF8,
CGA,
CGB3,
EZH2,
FCER2,
FUT4,
HTC2,
IGH,
JCHAIN,
IL3RA,
IL4R,
IL13,
MAOA,
BORCS8-MEF2B,
KMT2A,
CD200,
NFKB1,
NFKBIE,
NOS1,
NOS2,
CCND1,
PDCD1,
PIK3CA,
MEF2B
Drugs
3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione hydrochloride,
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus
3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione hydrochloride,
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus,
Autologous CD4+ and CD8+ T cells expressing a CD19-specific chimeric antigen receptor,
Autologous engineered anti -CD19 Chimeric Antigen Receptor (CAR +) T -cells
(
KYMRIAH
),
Axicabtagene ciloleucel
(
YESCARTA
),
Brentuximab vedotin
(
ADCETRIS
),
Enzastaurin hydrochloride,
Everolimus
(
AFINITOR,
VOTUBIA
),
Humanised Fc engineered monoclonal antibody against CD19,
Humanised anti-CD37 monoclonal antibody conjugated to maytansinoid DM1,
Ibrutinib
(
IMBRUVICA
),
Iodine (131I) tositumomab,
Lenalidomide
(
LENALIDOMIDE ACCORD,
REVLIMID
),
Mocetinostat,
Obinutuzumab
(
GAZYVA,
GAZYVARO
),
Pixantrone dimaleate
(
PIXUVRI
),
Polatuzumab vedotin
(
POLIVY
),
Pralatrexate
(
FOLOTYN
),
Recombinant histidine-tagged idiotype immunoglobulin Fab fragment of clonal B-cell receptors,
Rituximab
(
BLITZIMA,
MABTHERA,
TRUXIMA,
RITEMVIA,
RITUXAN,
RITUZENA,
RIXATHON,
RIXIMYO,
Ruxience
),
Selinexor
(
XPOVIO
),
Tazemetostat
(
TAZVERIK
),
Valproic acid, sodium,
Venetoclax
(
VENCLEXTA,
VENCLYXTO
),
haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate
Registered!
Primary mediastinal B-cell lymphoma (PMBL) is a rare subtype of diffuse large B-cell lymphoma (DLBCL; see this term), arising from B cells of thymic origin, that affects mainly women between the ages of 20-30, that usually presents with a bulky and rapidly expanding anterior mediastinal mass, often with pleural and pericardial effusions, and that can invade the lungs, superior vena cava, pleura, pericardium, and chest wall, leading to manifestations of cough, dyspnea, and superior vena cava syndrome.