Primary Sjögren Syndrome
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
STAT4,
TNFAIP3,
TNIP1,
GTF2I,
IL12A,
FCGR2A,
NCF1,
PTTG1,
ITSN2,
PHIP,
TNF,
PRDM1,
IRAK1BP1,
DGKQ,
TNFSF13B,
THBS1,
IL2,
IL2RA,
IL4,
TGFB1,
NFKBIA,
CCR7,
CYP19A1,
AIRE,
ID3,
ST14,
FAS,
TRAF3IP2,
MAP3K14,
HMOX1
STAT4,
TNFAIP3,
TNIP1,
GTF2I,
IL12A,
FCGR2A,
NCF1,
PTTG1,
ITSN2,
PHIP,
TNF,
PRDM1,
IRAK1BP1,
DGKQ,
TNFSF13B,
THBS1,
IL2,
IL2RA,
IL4,
TGFB1,
NFKBIA,
CCR7,
CYP19A1,
AIRE,
ID3,
ST14,
FAS,
TRAF3IP2,
MAP3K14,
HMOX1,
E2F1,
RORC,
IRF5,
HLA-DPB1,
RELN,
BLK,
IL10,
IL12A-AS1,
KLRG1,
COL11A2P1,
TRIM21,
HLA-DRA,
CALR,
ATN1,
RO60,
SSB,
IL17A,
IFNG,
TNPO3,
SHISA9,
IL6,
AQP5,
IL1B,
CXCL13,
CTSS,
BPIFA2,
HLA-DRB1,
CXCL10,
LILRA3,
MIR146A,
RBM45,
CA6,
MUC1,
HMGB1,
BCL2,
EGF,
IL18,
IL23A,
CXCL12,
CXCL8,
IFNA1,
HT,
MMP9,
IL21,
IL22,
REG1A,
MYDGF,
MUC5AC,
ISG20,
IL13,
ICAM1,
IFNB1,
IFNA13,
OAS1,
HLA-A,
RTEL1,
CRISP3,
TXLNA,
VCAM1,
LINC02605,
TRAF6,
TRBV20OR9-2,
CNTN2,
TNFSF13,
CXCR5,
BMP6,
SPTAN1,
CASP3,
ADIPOQ,
CCL21,
ACR,
CHRM3,
IL7,
NLRP3,
IGHV3-52,
NGF,
PRL,
MYD88,
STXBP3,
SYT1,
ADAM17,
TAP2,
CCR9,
XBP1,
PSPN,
TP53,
MALT1,
PUF60,
TXN,
BTG3,
VEGFA,
VIP,
IL17D,
STAT1,
TLR7,
LTA,
RAB4A,
PSPH,
ITPR3,
ITPR1,
MBL2,
ITGB2,
PSMB9,
PTEN,
ITGAL,
ITGAE,
MSMB,
MDK,
TREX1,
RIDA,
CCL18,
CXCL9,
CXCL11,
TRIM38,
FOXP3,
PAX6,
RBBP4,
IL27,
IL17F,
GZMA,
GSTT1,
GSTM1,
LOC102723407,
CD40,
AQP1,
GSN,
CXCL1,
HLA-DQA1,
AQP4,
AREG,
ASCL2,
CXCR3,
IL33,
C3,
MTOR,
HLA-B,
EGFR,
LOC102724971,
CTLA4,
IL5,
AGER,
IL1A,
ALB,
IL23R,
ICA1,
IGH,
HRES1,
CDKN2A,
MUC19,
MIR200B,
ABCA7,
RAB3D,
CLOCK,
APOBEC3B,
MIR31,
IKBKE,
MIR223,
LINC01139,
MFN2,
NR1I3,
MIR181A2,
CHST3,
MIR130A,
AKT3,
EBI3,
PRAMEF13,
PRG4,
NCR3,
MIR155,
CDK2AP2,
TRIM22,
ATG5,
UGT2B28,
ABCG2,
MIR34C,
H3P8,
XDH,
LAPTM5,
CXCR4,
H3P13,
TAM,
SEMA7A,
PERCC1,
USO1,
TP63,
IFNG-AS1,
VAMP8,
MIR4484,
MIR4695,
TNFSF14,
OCLN,
IL18R1,
MIR1207,
MIR1248,
NRP1,
PSS,
SEMA3A,
MIR551B,
MIR483,
MIR146B,
MIR448,
MIR377,
MSC,
MIAT,
MUC5B,
SLC26A9,
NOD1,
NAPB,
TRBV5-6,
TRBV6-2,
PDLIM3,
CHIA,
AICDA,
EDA2R,
ACAD8,
NUDT10,
HEYL,
GNL3,
MYCBP,
ATRNL1,
ROBO3,
DDX58,
LAMTOR2,
PYCARD,
TBK1,
CD274,
RETN,
ATF7IP,
VAC14,
RNPC3,
TRAT1,
LEF1,
IL17RB,
NUDT15,
NAT10,
TRIM68,
SF3B6,
RNF125,
TET2,
GORASP1,
PADI4,
IL25,
TPPP,
IFNLR1,
NXF1,
NRSN1,
TMEM132D,
TNFRSF13C,
DNAJC10,
GRAP,
DBA2,
CCL27,
SUB1,
MUC16,
TMED2,
CKAP4,
DSTN,
RPP14,
SEC14L2,
WDHD1,
CHP1,
NT5C1A,
HMCN1,
NR1I4,
FAM167A,
ATF6,
MAP1LC3B,
CUL9,
ASRGL1,
KCNH3,
ARHGAP45,
DHX40,
WNK1,
XBP1P1,
ABCA1,
TRPV1,
VIPR2,
GOLGA4,
GOLGA1,
FUCA2,
FUCA1,
FPR2,
FMR1,
FLNB,
F9,
ESR1,
ERV3-1,
EPHB2,
ELN,
EDNRA,
EDA,
DNASE1,
DLAT,
CYP1A1,
CX3CR1,
CTSD,
GOT2,
GPT,
GRN,
CCN1,
TNFRSF9,
IL12RB1,
CXCR2,
CXCR1,
IL7R,
IL6R,
IL1RN,
RBPJ,
IFI27,
GRIN2A,
IFI16,
HSPA4,
HOXC6,
HLA-H,
HLA-DRB3,
HIF1A,
GSTM2,
NR3C1,
CTSB,
CST3,
CRP,
AQP3,
TSPO,
BTK,
BDNF,
BCL6,
BAX,
ATHS,
ATD,
STS,
FASLG,
CA1,
APOH,
AMY1C,
AMY1B,
AMY1A,
AMH,
ALPP,
ALCAM,
ADA,
C4A,
CA2,
CR2,
CD44,
CP,
CNN3,
CLN3,
CFTR,
CENPB,
CDKN2D,
CD69,
CD68,
CD40LG,
CAST,
TNFRSF8,
CD27,
CD14,
CD9,
CD8A,
CD4,
CD2,
CASP1,
ILF2,
ILF3,
INSRR,
RPE65,
CX3CL1,
CCL25,
CCL22,
CCL17,
CCL5,
SATB1,
S100A9,
S100A8,
TRIM27,
SLC17A1,
RELA,
PLAAT4,
PVT1,
PTPN2,
PTN,
PSMB8,
PRTN3,
EIF2AK2,
SELE,
SLC22A1,
MAPK8,
TARBP1,
VDR,
UVRAG,
UBTF,
TTR,
TRPM2,
TPMT,
TNFRSF1A,
CLDN5,
TAP1,
SLPI,
TAC1,
STIM1,
STAT3,
SSRP1,
SPTBN1,
SPRR2A,
SPRR1B,
SOAT1,
MAP2K7,
MAPK1,
IRAK1,
LTF,
MSN,
MSH5,
MS,
MPO,
MMP3,
MMP2,
LYZ,
LY9,
LTBR,
MYC,
LPL,
LEPR,
LEP,
LCN1,
KRT6B,
KDR,
IRF2,
IRF1,
MUC4,
NCL,
PRKAB1,
PIK3CB,
PRKAA2,
PRKAA1,
PPBP,
PPARG,
PPARA,
POU2F1,
PIK3CG,
PIK3CD,
PIK3CA,
NFKB1,
SERPINA1,
PDCD1,
PAX3,
PAEP,
P2RX7,
OXTR,
NR4A2,
NFKBIL1,
H3P19
Drugs
—
Registered!
A rare systemic autoimmune disease characterized by exocrine gland dysfunction, resulting predominately in keratoconjunctivitis sicca and xerostomia, but also affecting exocrine glands of the skin, as well as respiratory, urogenital, and digestive tract. Extraglandular manifestations include arthritis, interstitial lung disease, renal disease, and peripheral neuropathy. The disease is accompanied by a substantially increased risk to develop B-cell non-Hodgkin lymphoma, especially MALT (mucosa-associated lymphoid tissue) lymphoma.