Palant Cleft Palate Syndrome

Clinical Features

Palant et al. (1971) described 2 sisters with severe mental and motor retardation, short stature, similar facial appearance (almond-shaped eyes with upward slant, bulbous nasal tip, prominent cupid-bow of upper lip), cleft palate, and similar limb abnormalities (camptodactyly of fingers 4 and 5, firm nonbony prominences on the anteromedial aspects of both wrists, etc.). Chromosomes were apparently normal. This is a type of syndrome that could be due to a small chromosomal aberration or even a repeated intrauterine insult. It is a type of syndrome that is difficult to categorize here for later recovery.