Acute Promyelocytic Leukemia
Watchlist
            
          Retrieved
            2022-04-26
          Source
            
          Trials
            
                —
              
            Genes
            
                  
                  NPM1, 
                  RARA, 
                  NUMA1, 
                  PML, 
                  ZBTB16, 
                  STAT5B, 
                  IRF2BP2, 
                  PRKAR1A, 
                  FLT3, 
                  F3, 
                  KIT, 
                  ITGAM, 
                  CEBPA, 
                  AKT1, 
                  THBD, 
                  DNMT3A, 
                  WT1, 
                  IFNG, 
                  STAT3, 
                  ITGB2, 
                  TBL1XR1, 
                  CD44, 
                  BCOR, 
                  DAPK2, 
                  AQP9, 
                  NRAS, 
                  ITGAL, 
                  CEBPE, 
                  IDH1, 
                  IDH2
                
                
                  
                  NPM1, 
                  RARA, 
                  NUMA1, 
                  PML, 
                  ZBTB16, 
                  STAT5B, 
                  IRF2BP2, 
                  PRKAR1A, 
                  FLT3, 
                  F3, 
                  KIT, 
                  ITGAM, 
                  CEBPA, 
                  AKT1, 
                  THBD, 
                  DNMT3A, 
                  WT1, 
                  IFNG, 
                  STAT3, 
                  ITGB2, 
                  TBL1XR1, 
                  CD44, 
                  BCOR, 
                  DAPK2, 
                  AQP9, 
                  NRAS, 
                  ITGAL, 
                  CEBPE, 
                  IDH1, 
                  IDH2, 
                  ITGAX, 
                  IL17A, 
                  TET2, 
                  NABP1, 
                  GLI2, 
                  GLI1, 
                  SMO, 
                  DEFA3, 
                  SMC1A, 
                  FNDC3B, 
                  MIR15A, 
                  FIP1L1, 
                  MIR16-1, 
                  BIRC5, 
                  RAP1GAP, 
                  ASXL1, 
                  CCL7, 
                  MYC, 
                  TP53, 
                  FANCB, 
                  PRAM1, 
                  CSF3, 
                  RAB40B, 
                  BCRP3, 
                  CD34, 
                  ANXA2, 
                  BCR, 
                  MPO, 
                  TNF, 
                  SMPD1, 
                  CD38, 
                  SUMO1, 
                  RUNX1, 
                  ABCB1, 
                  BCL2, 
                  ELANE, 
                  CD33, 
                  MECOM, 
                  NCAM1, 
                  SP100, 
                  CCR7, 
                  PIK3CG, 
                  PIK3CB, 
                  CTSG, 
                  BCRP2, 
                  PIK3CA, 
                  PIK3CD, 
                  IL1B, 
                  ANXA8, 
                  ANXA8L1, 
                  RUNX1T1, 
                  CDKN2A, 
                  NCOR2, 
                  TRIB3, 
                  CXCL8, 
                  RARG, 
                  ERBB2, 
                  THRA, 
                  CASP3, 
                  CEBPB, 
                  VEGFA, 
                  CDKN1A, 
                  ABL1, 
                  NFE2L2, 
                  GABPA, 
                  ANPEP, 
                  NCOR1, 
                  RNF4, 
                  SUB1, 
                  RUNX2, 
                  KMT2A, 
                  IRF8, 
                  AS3MT, 
                  ICAM1, 
                  AIDA, 
                  SET, 
                  TRBV20OR9-2, 
                  ABCC11, 
                  TERT, 
                  PTK2B, 
                  ABCC8, 
                  NXT1, 
                  HIF1A, 
                  CSF2, 
                  TBC1D9, 
                  RARB, 
                  C20orf181, 
                  CDKN2B, 
                  REG1A, 
                  CDKN2D, 
                  VAV1, 
                  HOTAIRM1, 
                  MRPL28, 
                  PTEN, 
                  MAPK14, 
                  CSF1R, 
                  G0S2, 
                  LGALS3, 
                  RXRA, 
                  PLG, 
                  MAPK3, 
                  S100A8, 
                  KRAS, 
                  H3P9, 
                  CYP26A1, 
                  HPRT1, 
                  PIN1, 
                  MAP2K1, 
                  HOXA1, 
                  SUMO2, 
                  PPARG, 
                  MAP2K7, 
                  SOAT1, 
                  KDM1A, 
                  PTPA, 
                  SMYD5, 
                  BRD4, 
                  ODC1, 
                  NUP98, 
                  IL23A, 
                  PADI4, 
                  XAB2, 
                  S100A10, 
                  IL10, 
                  JAK1, 
                  CRLF3, 
                  IL7R, 
                  IL4, 
                  IL3, 
                  PRDX4, 
                  MATN1, 
                  HTC2, 
                  MCL1, 
                  RELA, 
                  SGSM3, 
                  IRF1, 
                  PTPN11, 
                  ABCC1, 
                  PTGS2, 
                  IRF9, 
                  MFAP1, 
                  SYT1, 
                  MIR146A, 
                  FASLG, 
                  EGFR, 
                  PTF1A, 
                  ATG5, 
                  TSHR, 
                  TRAP, 
                  GSTK1, 
                  APRT, 
                  DAXX, 
                  UBA7, 
                  SLC25A10, 
                  MIRLET7C, 
                  UBE2L6, 
                  CRABP1, 
                  H3P38, 
                  TOP2B, 
                  KDM6A, 
                  RERE, 
                  ATRX, 
                  CDKN1B, 
                  BCL6, 
                  BLM, 
                  CD19, 
                  MIR221, 
                  GPRC5A, 
                  BCRP1, 
                  CXCR4, 
                  MBD2, 
                  BRCA1, 
                  TP73, 
                  NEAT1, 
                  ANXA1, 
                  FCGR1A, 
                  ST13, 
                  ABL2, 
                  GSTT1, 
                  GORASP1, 
                  GSTM1, 
                  HDAC9, 
                  WNK1, 
                  FUT4, 
                  FUT1, 
                  FLT1, 
                  H3P13, 
                  BAALC, 
                  ERG, 
                  EOMES, 
                  SLCO6A1, 
                  JAG1, 
                  THBS1, 
                  TGM2, 
                  PCGF2, 
                  TGFB1, 
                  F9, 
                  DLK1, 
                  ADAMTS13, 
                  IER3, 
                  CD84, 
                  TNFSF10, 
                  BLZF1, 
                  CDKL1, 
                  RASSF1, 
                  PRDX3, 
                  PIAS1, 
                  EHMT2, 
                  RPP14, 
                  CKAP4, 
                  TP63, 
                  TNFRSF10D, 
                  TNFRSF10C, 
                  IL18R1, 
                  TNFRSF10A, 
                  PIM2, 
                  SRA1, 
                  SQSTM1, 
                  PPIG, 
                  SLC9A3R1, 
                  CHST3, 
                  ATG7, 
                  BCAR1, 
                  NR1D1, 
                  RACK1, 
                  RIN1, 
                  KLK4, 
                  NDRG1, 
                  ISG15, 
                  ZMPSTE24, 
                  CDK2AP2, 
                  PCLAF, 
                  MVP, 
                  ATP6AP2, 
                  UBD, 
                  PDLIM7, 
                  EBP, 
                  AGPAT2, 
                  NAE1, 
                  CCNA1, 
                  TNFSF13B, 
                  CTCF, 
                  KHDRBS1, 
                  PDPN, 
                  RNF8, 
                  PRC1, 
                  AURKB, 
                  TXNIP, 
                  XPR1, 
                  DMTF1, 
                  NOG, 
                  TRIM16, 
                  MSC, 
                  WIF1, 
                  NAT1, 
                  CHEK2, 
                  CBLL2, 
                  MIR10B, 
                  MIR10A, 
                  MIR107, 
                  MIRLET7B, 
                  ASPG, 
                  NCR3LG1, 
                  NUP43, 
                  RAB7B, 
                  CLEC4D, 
                  NCR3, 
                  CENPV, 
                  PTCRA, 
                  GPR180, 
                  RMDN2, 
                  PTGDR2, 
                  DRAM2, 
                  OVCA2, 
                  PRRT2, 
                  CGB8, 
                  CGB5, 
                  LGALS12, 
                  HAVCR2, 
                  LMNB2, 
                  TCHP, 
                  USP48, 
                  ARHGAP24, 
                  RNF34, 
                  WLS, 
                  MIR125B1, 
                  MIR142, 
                  MIR143, 
                  MIR15B, 
                  H3P30, 
                  H3P8, 
                  LOC110013312, 
                  RN7SL263P, 
                  PGR-AS1, 
                  PCAT1, 
                  KLRC4-KLRK1, 
                  MIR766, 
                  SNORD112, 
                  PSG10P, 
                  NCF1, 
                  MIR382, 
                  MIR342, 
                  MIR340, 
                  XRCC6P5, 
                  ZFAS1, 
                  PSG8, 
                  MIR17HG, 
                  MIR34B, 
                  MIR34A, 
                  MIR29B2, 
                  MIR29B1, 
                  MIR223, 
                  MIR222, 
                  MIR192, 
                  MIR182, 
                  MIR181A2, 
                  DHDDS, 
                  LIN28A, 
                  MUL1, 
                  HIPK2, 
                  LAMTOR2, 
                  IGHV1-12, 
                  EML4, 
                  HPGDS, 
                  PDCD4, 
                  DISC1, 
                  ZBTB32, 
                  GNL3, 
                  PHGDH, 
                  SENP3, 
                  WIPI2, 
                  ZNF451, 
                  PRDX5, 
                  SH3BP4, 
                  NUP62, 
                  CDK20, 
                  PRAME, 
                  SUZ12, 
                  PHF8, 
                  PEG10, 
                  MYCBP2, 
                  WDFY3, 
                  DKK1, 
                  KLRK1, 
                  GABARAPL2, 
                  USP18, 
                  SP140, 
                  RGCC, 
                  KLF15, 
                  MARCKSL1, 
                  DERL2, 
                  GPSM3, 
                  BCORL1, 
                  USP37, 
                  ARID1B, 
                  PNPLA2, 
                  CHPT1, 
                  ENAH, 
                  SYBU, 
                  KRBOX4, 
                  QRSL1, 
                  RMDN3, 
                  MSTO1, 
                  PIWIL2, 
                  WIPI1, 
                  SWT1, 
                  RHOF, 
                  MBD3, 
                  BCL11A, 
                  KDM3B, 
                  ASB2, 
                  GINS2, 
                  SF3B6, 
                  IKBKG, 
                  WT1-AS, 
                  LEF1, 
                  DCTN4, 
                  RMDN1, 
                  PIR, 
                  CCL5, 
                  CNTNAP1, 
                  IGFBP3, 
                  GATA2, 
                  FOS, 
                  FLG, 
                  FOXO3, 
                  FOXO1, 
                  FOXC1, 
                  FH, 
                  FGFR1, 
                  FGF13, 
                  FEN1, 
                  F13B, 
                  F13A1, 
                  F10, 
                  F2RL1, 
                  F2, 
                  EZH2, 
                  EYA2, 
                  ETV6, 
                  ERBB4, 
                  EPS15, 
                  EPHB2, 
                  EP300, 
                  ELAVL1, 
                  EIF4G2, 
                  EIF4EBP1, 
                  EGR1, 
                  EGF, 
                  KAT2A, 
                  GCY, 
                  GDNF, 
                  HLA-DRB1, 
                  ID1, 
                  HTR3A, 
                  HSPG2, 
                  HSP90AB1, 
                  HSP90AA1, 
                  HES1, 
                  HOXD3, 
                  HOXB2, 
                  HOXA9, 
                  HNMT, 
                  HMGN2, 
                  HMGN1, 
                  HK3, 
                  GFRA1, 
                  HIC1, 
                  HHEX, 
                  HGF, 
                  HFE, 
                  HDAC1, 
                  HCK, 
                  GTF2I, 
                  GTF2H1, 
                  GSTP1, 
                  GSK3B, 
                  GLB1, 
                  GHR, 
                  EFNA4, 
                  E2F1, 
                  DTNA, 
                  AIRE, 
                  CAMP, 
                  CAD, 
                  BRAF, 
                  BMP6, 
                  BMP4, 
                  BMP2, 
                  BIK, 
                  BAX, 
                  ARSD, 
                  AR, 
                  AQP7, 
                  FAS, 
                  APAF1, 
                  CASP10, 
                  ANXA5, 
                  ANXA3, 
                  ALOX5, 
                  ALK, 
                  ALB, 
                  AGTR2, 
                  AGL, 
                  ADCY9, 
                  ADCY7, 
                  ACTL6A, 
                  ACTB, 
                  ABO, 
                  CASP8, 
                  CBR1, 
                  ATN1, 
                  CGB3, 
                  ARID3A, 
                  DNMT1, 
                  DIO3, 
                  DAPK1, 
                  DAP, 
                  CYP2B6, 
                  CUX1, 
                  CRYBA1, 
                  CREB1, 
                  KLF6, 
                  CEACAM7, 
                  CEACAM3, 
                  CGA, 
                  CCNA2, 
                  CEACAM5, 
                  CD52, 
                  CDKN2C, 
                  CDC25C, 
                  CDK1, 
                  CD68, 
                  CD47, 
                  CD14, 
                  CD6, 
                  CD2, 
                  CCNE1, 
                  CCNB1, 
                  ID2, 
                  IL1A, 
                  PPM1D, 
                  IL6, 
                  TGM1, 
                  TGFA, 
                  TFRC, 
                  TERC, 
                  TACR1, 
                  STAT5A, 
                  STAT2, 
                  STAT1, 
                  SPI1, 
                  SOD1, 
                  SUMO3, 
                  SMARCA4, 
                  SLC1A2, 
                  SHB, 
                  SFRP1, 
                  SDHD, 
                  SCT, 
                  ATXN1, 
                  S100A9, 
                  RPE65, 
                  RNPEP, 
                  RNASE3, 
                  RET, 
                  PLAAT4, 
                  RAF1, 
                  RAD21, 
                  PVT1, 
                  TIMP1, 
                  TNFAIP2, 
                  TPMT, 
                  ZFP36, 
                  NR0B2, 
                  FZD9, 
                  ARID1A, 
                  TAM, 
                  NCOA3, 
                  CDR3, 
                  WT4, 
                  TFEB, 
                  DEK, 
                  ZMYM2, 
                  RNF112, 
                  MZF1, 
                  XRCC1, 
                  TWIST1, 
                  XPO1, 
                  XBP1, 
                  WNT5A, 
                  VIM, 
                  VHL, 
                  VDR, 
                  UVRAG, 
                  UCN, 
                  UBE2I, 
                  UBE2E2, 
                  TYMS, 
                  TXNRD1, 
                  PTPRC, 
                  PTPN6, 
                  PTGS1, 
                  MCM2, 
                  MRE11, 
                  MPST, 
                  MPL, 
                  MMP9, 
                  AFF1, 
                  MLLT1, 
                  MAP3K10, 
                  MLF1, 
                  MGMT, 
                  RAB8A, 
                  MEIS1, 
                  MDM4, 
                  SMAD4, 
                  COX1, 
                  LPA, 
                  LMO2, 
                  LMNB1, 
                  LMNA, 
                  LGALS1, 
                  LBR, 
                  STMN1, 
                  LAMP1, 
                  KLRD1, 
                  KLRB1, 
                  IL18, 
                  IL15, 
                  MSH3, 
                  MYB, 
                  PTGDS, 
                  PLSCR1, 
                  PSMC6, 
                  PSG5, 
                  PSG2, 
                  PROS2P, 
                  MAPK8, 
                  MAPK1, 
                  PRKCB, 
                  PRKCA, 
                  SRGN, 
                  PRF1, 
                  POLD1, 
                  PMAIP1, 
                  PLAT, 
                  NEDD8, 
                  PHB, 
                  PGR, 
                  PFAS, 
                  PECAM1, 
                  PDGFRB, 
                  PBX1, 
                  PAX5, 
                  PRKN, 
                  NOTCH1, 
                  NME1, 
                  NGFR, 
                  NFIL3, 
                  H3P10
                
                
              Drugs
            
                —
              
            Registered!
                
          
        
        
                    
                    Acute promyelocytic leukemia (APL) is an aggressive type of acute myeloid leukemia in which there are too many immature blood-forming cells (promyelocytes) in the blood and bone marrow. This build up of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body. The signs and symptoms of APL include an increased risk to both bleed and form blood clots. Individuals may also experience excessive tiredness, pain in affected areas, loss of appetite, and weight loss. APL usually occurs in middle-aged adults, but can be diagnosed at any age. It is caused by a mutation that is acquired over a person's lifetime, usually involving a translocation between chromosomes 15 and 17.  Treatment may include the use of all-trans retinoic acid (ATRA) and arsenic trioxide or anthracycline-based chemotherapy.