Premature Aging Syndrome, Okamoto Type

Okamoto et al. (1997) described an apparently new premature aging syndrome in a 15-year-old girl with severe growth and developmental abnormalities. Features also included osteosarcoma, cataracts, diabetes mellitus, osteoporosis, and erythroid macrocytosis. A photograph showed a round face, microcephaly, poor hair growth, flat nasal bridge, and low-set somewhat deformed ears. The parents were healthy and unrelated.