Von Hippel-Lindau Disease

Watchlist

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Retrieved

2022-04-26

Source

Gard

Trials

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Genes

VHL, CCND1, VEGFA, RET, SDHB, TCHP, HIF1A, RAF1, SETD2, SDHD, EPAS1, CBLL2, EPO, PRKN, MUL1, CUL2, ELOB, MEN1, PTEN, RARB, FN1, THRB, FHIT, TP53, NF1, APC, CXCR4, CHGA, BRCA1, FLCN

VHL, CCND1, VEGFA, RET, SDHB, TCHP, HIF1A, RAF1, SETD2, SDHD, EPAS1, CBLL2, EPO, PRKN, MUL1, CUL2, ELOB, MEN1, PTEN, RARB, FN1, THRB, FHIT, TP53, NF1, APC, CXCR4, CHGA, BRCA1, FLCN, PTHLH, SDS, MKI67, RASSF1, ATP2B2, PNMT, ELOC, SORD, MAX, CA9, SARDH, PROM1, IGF1R, HTC2, MIR155, EGLN3, DDIT4, VBP1, SLC49A4, SDHC, SESN2, BRK1, MIB1, SST, EPOR, STK11, AURKA, TIMP3, TCP1, TH, TGM2, TGFBI, TGFB1, ELOA, TGFA, TRBV20OR9-2, HNF1B, ADRB2, RWDD3, WT1, TUSC3, RBMXL1, MIR21, VHLL, RBMY1D, HYLS1, TDRD9, DERL3, SYVN1, JADE1, RHBDF2, CDC73, RAPH1, TMEM127, PBRM1, SDHAF2, EGLN1, PIAS4, LEF1, ANGPTL4, HILPDA, CD274, SMUG1, JMJD6, RAB40B, SIX2, CIB1, RBX1, BAP1, ELL, SPP1, RBMY1A1, SMN2, SMN1, EGFR, ERG, F10, FECH, FLT1, GCG, GNA12, GRN, NR3C1, HPT, IDH2, IGF1, KLRD1, LHX1, MAGEA1, DNMT1, DAPK1, CLU, CCT, APEH, APOH, AR, ATP1B1, BRCA2, CALCA, CD38, CISH, CDH1, CDK4, CDK6, CDKN1A, CDKN1B, CGA, MAZ, MET, MIP, RHEB, PIK3CG, PLAU, PTGS2, PYGM, RARA, RB1, CXCL12, PIK3CB, SEC13, SFRP1, SLC2A3, SLC6A2, SLC18A1, SLC18A2, PIK3CD, PIK3CA, MITF, MYC, MMP1, MMP3, MMP14, MST1, COX2, MYBL2, NF2, SERPINA1, NME1, NPY, NTRK1, SERPINE1, PAX2, PDGFRB, MTCO2P12

Drugs

Propranolol hydrochloride ( HEMANGEOL )

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Von Hippel-Lindau (VHL) disease is an inherited disorder characterized by the abnormal growth of both benign and cancerous tumors and cysts in many parts of the body. Tumors usually first appear in young adulthood. The types of tumors associated with VHL disease include hemangioblastomas (slow-growing tumors of the central nervous system); kidney cysts and clear cell renal cell carcinoma; pancreatic neuroendocrine tumors; pheochromocytomas (noncancerous tumors of the adrenal glands); and endolymphatic sac tumors. VHL disease is caused by a mutation in the VHL gene and is inherited in an autosomal dominant manner. Early detection and treatment of VHL disease is important, and usually involves surgical removal of tumors.