Ischemic Cardiomyopathy

Watchlist

(log in to enable)

Retrieved

2021-01-18

Source

Wikipedia

Trials

—

Genes

WNT16, LMNA, KIF26B, ACE, SLC6A8, CALCR, CALR, GJA1, SLC5A1, ACE2, VEGFA, CSF3, CXCL12, ADIPOQ, NCAM1, MIR126, TNF, PLN, MAPK3, DMD, TPO, TM7SF2, TXN, ADCYAP1, TIMP1, TGFB1, TEK, SPP1, CSRP3, SP100

WNT16, LMNA, KIF26B, ACE, SLC6A8, CALCR, CALR, GJA1, SLC5A1, ACE2, VEGFA, CSF3, CXCL12, ADIPOQ, NCAM1, MIR126, TNF, PLN, MAPK3, DMD, TPO, TM7SF2, TXN, ADCYAP1, TIMP1, TGFB1, TEK, SPP1, CSRP3, SP100, SLC6A4, SLC5A2, SDHB, SCD, PXDN, ABCG2, PDE5A, MBTPS1, MIR508, MIR21, IL34, ZBP1, NOX5, MARCKSL1, RHOU, SUGP1, PCDHGA3, TRPM7, RNF111, ASB1, FOXP3, NOX4, HIPK2, ANKRD1, PHLDA1, PTGDR2, CITED2, RENBP, HAND1, ATXN1, PGF, RBP4, FOXM1, ESRRB, ESR1, CHRNA4, CEBPD, SCARB1, RUNX1, CASP3, CACNA1C, VPS51, BCL3, AXL, ATP2A2, ARHGAP1, ANGPT2, ANGPT1, ALB, ALAS2, AKT1, AGT, GRK3, GRK2, PTK2B, GATA4, ABCB1, GH1, ADRB1, SERPINE1, OGG1, ROR1, NOS2, NOS1, MYC, MUC2, MPO, MMP3, MME, SMAD2, IL18, IL6, CCN1, IGFBP3, IGF1, IFIT3, HIF1A, HGF, GRK5, MIR662

Drugs

—

Interested in hearing about new therapies?

Ischemic cardiomyopathy is a type of cardiomyopathy caused by a narrowing of the coronary arteries which supply blood to the heart. Typically, patients with ischemic cardiomyopathy have a history of acute myocardial infarction, however, it may occur in patients with coronary artery disease, but without a past history of acute myocardial infarction. This cardiomyopathy is one of the leading causes of sudden cardiac death. The adjective ischemic means characteristic of, or accompanied by, ischemia — local anemia due to mechanical obstruction of the blood supply.

Signs and symptoms

Signs and symptoms of ischemic cardiomyopathy include sudden fatigue, shortness of breath, dizziness, and palpitations.

Cause

Ischemic cardiomyopathy is the cause of more than 60% of all cases of systolic congestive heart failure in most countries of the world. A chest radiograph that demonstrates coronary artery calcification is a probable indication of ischemic cardiomyopathy.

The following are causes of ischemic cardiomyopathy:

Diabetes
Atherosclerosis
Vasospasm
Inflammation of arteries

Pathophysiology

Ischemic cardiomyopathy is caused by too little blood flow and hence oxygen reaching the muscular layer of the heart due to a narrowing of coronary arteries in turn causing cell death. This can cause different levels of tissue injury and affect large and intermediate arteries alike.

Diagnosis

Ischemic cardiomyopathy can be diagnosed via magnetic resonance imaging (MRI) protocol, imaging both global and regional function. Also the Look-Locker technique is used to identify diffuse fibrosis; it is therefore important to be able to determine the extent of the ischemic scar. Some argue that only left main- or proximal-left anterior descending artery disease is relevant to the diagnostic criteria for ischemic cardiomyopathy. Myocardial imaging usually demonstrates left ventricular dilation, severe ventricular dysfunction, and multiple infarctions. Signs include congestive heart failure, angina edema, weight gain and fainting, among others.

Management

Play media

Cardiac-Stem-Cells

Restoring adequate blood flow to the heart muscle in people with heart failure and significant coronary artery disease is strongly associated with improved survival, some research showing up to 75% survival rates over 5 years. A stem cell study indicated that using autologous cardiac stem cells as a regenerative approach for the human heart (after a heart attack) has great potential.

American Heart Association practice guidelines recommend implantable cardioverter-defibrillator (ICD) use in those with ischemic cardiomyopathy (40 days post-MI) that are (NYHA) New York Heart Association functional class I. A LVEF measurement (simply called LVEF alone among cardiologists) of greater than (>) 30% is often used to differentiate primary from ischemic cardiomyopathy, and as a prognostic indicator.

Coronary artery bypass surgery

A 2004 study showed the patients in that study who underwent ventricular restoration as well as a coronary artery bypass achieved greater postoperative LVEF than with the latter surgery alone. Severe cases are treated with heart transplantation.

Prognosis

One of the most important features differentiating ischemic cardiomyopathy from the other forms of cardiomyopathy is the shortened, or worsened all-cause mortality in patients with ischemic cardiomyopathy. According to several studies, coronary artery bypass graft surgery has a survival advantage over medical therapy (for ischemic cardiomyopathy) across varied follow-ups.