Acromegaly

Watchlist

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Retrieved

2022-04-26

Source

Gard

Trials

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Genes

GH1, AIP, IGF1, GNAS, GPR101, SST, GHR, MEN1, PTPRF, GHRH, SSTR2, SSTR5, PRL, IGFBP3, AHR, PPARG, IGF1R, POU1F1, SOCS2, PRKAR1A, SLC20A1, CDKN1B, BRAF, REN, CST3, SSTR1, AGT, MTHFR, RET, SMS

GH1, AIP, IGF1, GNAS, GPR101, SST, GHR, MEN1, PTPRF, GHRH, SSTR2, SSTR5, PRL, IGFBP3, AHR, PPARG, IGF1R, POU1F1, SOCS2, PRKAR1A, SLC20A1, CDKN1B, BRAF, REN, CST3, SSTR1, AGT, MTHFR, RET, SMS, VDR, ARRB1, FGF21, GIPR, KL, TRIM21, GDNF, POMC, ESRP1, CALR, TP53, ACE, CDKN2A, TRH, TWIST1, TP73, TXN, SLPI, VEGFA, TNFSF11, TRHR, ZHX2, DGCR2, ABCB6, ZGLP1, MIR660, MIR21, ZACN, RSS, ARHGAP24, ASRGL1, EHMT1, FTO, MIB1, NDRG2, NPDC1, GPRC5C, GPRC5D, NAT10, UGT1A1, GHRL, SOST, PDLIM3, ATRNL1, RAB18, CCL2, CHEK2, UTS2, CCL27, CIB1, NAMPT, SLC5A2, GRK2, SRL, CYP11B2, GSTP1, GNAI2, GLP1R, GIP, GHRHR, GCG, FLNA, FGF2, E2F1, DPP4, DMBT1, CTSB, IGSF1, CRP, CISH, CALCA, CA1, BTF3P11, BAX, ATHS, APOE, AMH, ALPP, AGTR1, HSD11B1, INS, S100A1, OGG1, RORC, BRD2, RENBP, RAF1, PTPN4, PTPN3, PTH, AGRP, PRKACB, PLAGL1, TNFRSF11B, NRAS, EIF6, NPPB, NCAM1, MYC, MTRR, MTR, MMP2, MKI67, LPL, LGALS3, LEP, JAK2, H3P10

Drugs

2'-O-(2-Methoxyethyl) phosphorothioate antisense oligonucleotide targeting the growth hormone receptor, Cyclo(-gamma-aminobutyryl-L-phenylalanyl-L-tryptophanyl-D-tryptophanyl-L-lysyl-L-threonyl-L phenylalanyl-N-3-carboxypropyl)-glycine amide, acetate salt, Lanreotide acetate ( SOMATULINE DEPOT, SOMATULINE LP ), Octreotide ( SANDOSTATINE ), Octreotide acetate (oral use), Octreotide chloride (lipid depot solution), Pasireotide ( SIGNIFOR, SIGNIFOR LAR ), Pegvisomant ( SOMAVERT ), Recombinant protein consisting of modified human growth hormone releasing hormone and the translocation and endopeptidase domains of botulinum toxin serotype D, Vapreotide

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Acromegaly occurs when the pituitary gland makes too much growth hormone (GH). It is most often diagnosed in middle-aged adults, although symptoms can appear at any age. Signs and symptoms include abnormal growth of the hands and feet and overgrowth of the bones in the face. Other symptoms may include joint pain, headache, backbone fractures, high blood pressure, and diabetes. Acromegaly is most often caused by non-cancerous tumors on the pituitary called adenomas. In some cases, acromegaly occurs because of a genetic variant in one of several different genes. Acromegaly may also be part of other genetic syndromes such as multiple endocrine neoplasia syndrome type 1 and type 4, hereditary paraganglioma-pheochromocytoma syndrome, McCune-Albright syndrome, neurofibromatosis, or Carney complex. Diagnosis is based on the symptoms, clinical examination and laboratory tests. Treatment is focused on managing the symptoms and may include hormones, various medications, radiotherapy, and surgery. When left untreated, it can result in serious illness and premature death.