Familial Alzheimer Disease
Watchlist
Retrieved
2022-04-26
Source
Trials
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Genes
TOMM40,
TREM2,
ABCA7,
APP,
APOE,
PSEN2,
PSEN1,
MAPT,
SORL1,
PRNP,
CASP3,
BACE1,
GSK3B,
NCSTN,
IDE,
IL1B,
HFE,
A2M,
ACE,
DHCR24,
BIN1,
ESR1,
ADAM10,
ADAMTS1,
PGRMC1,
VEGFA,
ARC,
CYP46A1,
SLC30A4,
VSNL1
TOMM40,
TREM2,
ABCA7,
APP,
APOE,
PSEN2,
PSEN1,
MAPT,
SORL1,
PRNP,
CASP3,
BACE1,
GSK3B,
NCSTN,
IDE,
IL1B,
HFE,
A2M,
ACE,
DHCR24,
BIN1,
ESR1,
ADAM10,
ADAMTS1,
PGRMC1,
VEGFA,
ARC,
CYP46A1,
SLC30A4,
VSNL1,
PICALM,
HMOX1,
HLA-DRB5,
IGF1R,
IGF1,
INPP5D,
IGF2,
MPO,
NPY,
NOS3,
PLAU,
PLCG2,
PPARG,
RELN,
MTHFR,
PYY,
NECTIN2,
SLC2A4,
IGF2R,
SOD2,
MAOB,
TF,
LEP,
TFAM,
INSR,
INS,
TNF,
TPI1,
EPHA1,
F2,
ENO1,
CR1,
CASS4,
ATP5F1A,
CLU,
CHRNB2,
CHRNA7,
MIR766,
CD33,
IQCK,
EIF2S1,
MIR505,
APOC1,
CALM1,
MIR100,
MIR146A,
BDNF,
BCL2,
MIR375,
MIR296,
BCHE,
MIR708,
TPP1,
SLC30A6,
SNAR-I,
DPYSL2,
ACHE,
CD2AP,
GAPDHS,
PCDH11X,
CYP2D6,
MIR4467,
CRH,
MIR3622B,
BAX,
AMFR,
ABI3,
CST3,
MS4A4A,
WWOX,
BRCA2,
FANCD2,
TFF1,
TAS2R64P,
CTNNB1,
SUCLA2,
SNCA,
CTSD,
RNR2,
NEFL,
TAS2R62P,
SOD1,
ITPR3,
ITPR2,
ITPR1,
FLAD1,
PSENEN,
TP53,
CDK5R1,
EIF2AK3,
UBQLN1,
ALG3,
PIK3CG,
PIK3CA,
PIK3CD,
SERPINA3,
PIK3CB,
DOCK3,
APLP1,
OGDH,
CREB1,
NOTCH1,
CASP6,
NGF,
CCND1,
FOS,
DLX4,
DLG4,
DDIT3,
RABGEF1,
PEBP1,
PYCARD,
DAPK2,
KCNIP3,
CTSB,
CSF2,
CRMP1,
CTSG,
EHMT2,
ENO2,
ERBB4,
TMED10,
TERF2IP,
PTK2B,
FCN2,
PTGES3,
FGF2,
ACKR1,
DNM1L,
SDC3,
G6PD,
GCHFR,
ITM2B,
CREBBP,
MAP3K8,
TRPM7,
ADI1,
MTCO2P12,
UPK3B,
ACTB,
AKT1,
AKT2,
ANXA1,
APBB1,
DNLZ,
STS,
MIR34A,
BRCA1,
MIR137,
C5AR1,
DDR1,
CAMK4,
TMED10P1,
MPEG1,
C9orf72,
ESCO1,
CDCA5,
PRRT2,
MAP1LC3B,
CAT,
EHMT1,
CNR2,
SPPL2B,
RAB9A,
NRXN3,
GFAP,
SYNJ1,
SERPINB5,
CD99,
MME,
MNAT1,
CCL2,
RRAS,
RPS27,
RPS21,
RAP1A,
PYCR1,
COX2,
PTS,
PTGS2,
MTHFD1,
MMUT,
NCAM1,
NFIA,
NFIB,
MAPK8,
MAPK3,
PRKCB,
PRKCA,
PPBP,
MED1,
NFIC,
PPARA,
NFIX,
PKD1,
NOTCH3,
NRGN,
MEOX2,
MEF2A,
SPRR2A,
TTC3,
GRIN2A,
DENR,
GRIN2B,
RAB7A,
LRP8,
HPRT1,
HSP90AA1,
VIM,
IDUA,
UTRN,
SUMO1,
UBE2I,
TTK,
TPT1,
SULT1E1,
IL1A,
IL6,
IL12A,
TSPAN6,
TIE1,
TGFB1,
TG,
KNG1,
LAMC2,
LGALS3,
TERT,
TERC,
STIM1,
H3P17
Drugs
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Registered!
Familial Alzheimer disease (familial AD) is a degenerative disease of the brain that causes gradual loss of memory, judgment, and the ability to function socially. About 25% of all Alzheimer disease is familial (more than 2 people in a family have AD). When Alzheimer disease begins before 60 or 65 years of age (early-onset AD) about 60% of the cases are familial (also known as Early-onset familial AD). These cases appear to be inherited in an autosomal dominant manner.
There are three subtypes of early-onset familial AD which are each associated with changes (mutations) in unique genes:
(1) Alzheimer disease, type 1 is caused by mutations in the APP gene
(2) Alzheimer disease, type 3 is caused by mutations in the PSEN1 gene
(3) Alzheimer disease, type 4 is caused by mutations in the PSEN2 gene.
The condition known as late-onset familial AD includes only the subtype Alzheimer disease, type 2 and is associated with the APOE*4 allele on chromosome 19. This condition results in an increased risk of having AD.
There are three subtypes of early-onset familial AD which are each associated with changes (mutations) in unique genes:
(1) Alzheimer disease, type 1 is caused by mutations in the APP gene
(2) Alzheimer disease, type 3 is caused by mutations in the PSEN1 gene
(3) Alzheimer disease, type 4 is caused by mutations in the PSEN2 gene.
The condition known as late-onset familial AD includes only the subtype Alzheimer disease, type 2 and is associated with the APOE*4 allele on chromosome 19. This condition results in an increased risk of having AD.