Splenic Marginal Zone Lymphoma
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
TP53,
NOTCH2,
BRAF,
CCND1,
IGH,
MYD88,
BIRC3,
BCL2,
LOC102724971,
LOC102723407,
KLF2,
IGHV3-69-1,
IGHV1-2,
FCER2,
IRF5,
KRT20,
MALT1,
TLR9,
TNFAIP3,
IKBKB,
TCL1A,
MS4A1,
ZNF608,
MIB1,
BHLHE40,
TCL1B,
KMT2B,
FAM72A,
FAM72B,
MIR26B
TP53,
NOTCH2,
BRAF,
CCND1,
IGH,
MYD88,
BIRC3,
BCL2,
LOC102724971,
LOC102723407,
KLF2,
IGHV3-69-1,
IGHV1-2,
FCER2,
IRF5,
KRT20,
MALT1,
TLR9,
TNFAIP3,
IKBKB,
TCL1A,
MS4A1,
ZNF608,
MIB1,
BHLHE40,
TCL1B,
KMT2B,
FAM72A,
FAM72B,
MIR26B,
PDE10A,
MIR223,
SMUG1,
FOXP1,
B3GAT1,
SGSM3,
IGHV3OR16-7,
IGHV4-39,
MIR182,
IGHV3-52,
IGHV3-21,
MIR16-1,
IGHV1-69,
MIR15A,
IGKV3-20,
SLC35B2,
TLR7,
CYP4V2,
ARID1A,
CENPX,
AMOTL1,
SMYD1,
POLE3,
TGFB1,
CLLS2,
CDK6,
IFNA13,
IFNA1,
CXCR3,
FUT4,
ERCC3,
EPHB2,
CREBBP,
CD38,
ISG20,
TNFRSF8,
CD80,
CD22,
CCND2,
SERPING1,
BTK,
BCL6,
IL2RA,
LTB,
KMT2D,
PTPRC,
TRAF3,
TERT,
SYK,
SOX11,
SLC22A2,
SLC7A4,
RB1,
MAPK1,
MME,
POU2F2,
PLAT,
PIK3CD,
PAX5,
NOTCH1,
NFKB2,
NCAM1,
H3P11
Drugs
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus,
Axicabtagene ciloleucel
(
YESCARTA
),
Bendamustine for 50 ml admixture
(
BENDEKA
)
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus,
Axicabtagene ciloleucel
(
YESCARTA
),
Bendamustine for 50 ml admixture
(
BENDEKA
),
Cladribine
(
LITAK
),
Copanlisib
(
ALIQOPA
),
Ibrutinib
(
IMBRUVICA
),
Idelalisib
(
ZYDELIG
),
Iodine (131I) tositumomab,
Lenalidomide
(
LENALIDOMIDE ACCORD,
REVLIMID
),
Lutetium (177LU) lilotomab satetraxetan,
Obinutuzumab
(
GAZYVA,
GAZYVARO
),
Parsaclisib,
haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate
Registered!
Splenic marginal zone lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma characterized by abnormal clonal proliferation of mature B-lymphocytes with involvement in the spleen, bone marrow and, frequently, the blood. It usually presents with splenomegaly, lymphocytosis, anemia and/or thrombocytopenia. Hepatitis C virus and autoimmune manifestations, such as autoimmune hemolytic anemia and autoimmune thrombocytopenia, could be associated.