Prostate Cancer, Hereditary, 4

Watchlist

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Retrieved

2019-09-22

Source

Omim

Trials

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Genes

RNASEL, HOXB13, ELAC2, MSR1, CHEK2, BRCA2, BRCA1, CDKN1B, MSMB, SRD5A2, CDH1, EPHB2, NBN, TTC28, LARP4B, KDM2A, BCL2L11, TSHZ1, HAUS6, DENND4B, ADGRG1, MBD2, BCAS1, PPFIBP2, TCF7L2, HNF1B, TCF4, B3GAT1, MAD1L1, UHRF1BP1, COL23A1, RN7SKP114, RNU6-491P, RNU6-148P, THEG5, MEIS1-AS3, OACYLP, DUBR, RASSF3, CDCA7, RNF43, MOB2, ATAT1, SUGCT, RFX7, PKNOX2, FBRSL1, KNL1, RNLS, EMSY, RNU6-456P, DOCK2, PAX9, MYO9B, MMP14, POU2F2, MBNL1, MAP2K1, ITGB8, INCENP, CHD3, HLA-DOA, DNMT3B, MECOM, CASP8, BCL2, ATM, ARHGAP6, TOR1A, KLK3, PCAP, CBX4, HPCX, AMACR, KLF6, AR, HPC3, CYP17A1, MYC, NPEPPS, PROS1, PSAT1, PLAG1, GSTK1, CYP19A1, RGS8, BRIP1, SLCO6A1, MIR888, ARL11, CYP1B1, CYP1A1, RGSL1, SULT1A1, PALB2, ERG, RASA1, PTEN, TP53, VDR, SPOP, PPM1D, PPP2R2A, PON1, PKHD1, LZTS1, MLH1, LGALS8, KLK2, RASA2, PINX1, GSTT1, PDSS2, GSTP1, GSTM1, CT55

Drugs

Mitoxantrone ( NOVANTRONE )

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For a general discussion of hereditary prostate cancer, see 176807.

Mapping

Because Americans of Ashkenazi Jewish descent comprise a population with a relatively limited number of founders, Friedrichsen et al. (2004) hypothesized that genomewide linkage analyses of hereditary prostate cancer families in this population would increase locus homogeneity and the likelihood of finding a true susceptibility locus. They therefore performed a genomewide scan of 36 Jewish families: 17 from the Fred Hutchinson Cancer Research Center and 19 families collected by The Johns Hopkins University. The data highlighted the 7q11-q21 region, with a nonparametric linkage (NPL) score of 3.01. After genotyping additional markers within the 7q11-q21 peak, the NPL score increased to 3.35.

Molecular Genetics

By screening 541,129 SNPs in a large 2-stage genomewide association study of prostate cancer involving white participants from the United Kingdom and Australia, Eeles et al. (2008) found association of a single-nucleotide polymorphism (SNP) in intron 9 of the LMTK2 gene (610989), rs6465657, and susceptibility to prostate cancer (P = 1.1 x 10(-9)). The LMTK2 gene maps to chromosome 7q21-q22.