Uveal Melanoma
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
GNA11,
BAP1,
GNAQ,
SF3B1,
CYSLTR2,
PLCB4,
EIF1AX,
JMJD6,
GRM1,
CLPTM1L,
TDP1,
LRP1B,
OCA2,
TP53,
CDKN2A,
MAP2K7,
BRAF,
STAP1,
CACNA2D1,
VEGFA,
OCM,
RASSF1,
AKT1,
YAP1,
HIF1A,
CD274,
CTLA4,
TYR,
PRAME,
H3P10
GNA11,
BAP1,
GNAQ,
SF3B1,
CYSLTR2,
PLCB4,
EIF1AX,
JMJD6,
GRM1,
CLPTM1L,
TDP1,
LRP1B,
OCA2,
TP53,
CDKN2A,
MAP2K7,
BRAF,
STAP1,
CACNA2D1,
VEGFA,
OCM,
RASSF1,
AKT1,
YAP1,
HIF1A,
CD274,
CTLA4,
TYR,
PRAME,
H3P10,
ACKR3,
PIK3CG,
PIK3CA,
PIK3CB,
PIK3CD,
CXCR4,
CXCR6,
LPAR2,
ADRA1A,
ADRA2B,
KIT,
MET,
EDNRA,
ATN1,
SSTR4,
BRS3,
PTP4A3,
IGF1,
MAPK3,
BCL2,
GPR42,
TNF,
HSPB1,
HSPB2,
IL6,
NME1,
HTR2B,
PTEN,
PVT1,
EGF,
CD47,
BRCA2,
PERP,
HSPB3,
CDK4,
PROM1,
GPR151,
COASY,
PRRT2,
MRGPRX3,
PRKCB,
PRKCA,
MRGPRX4,
RASEF,
CCL2,
OXER1,
GPRC6A,
MRGPRX1,
PDCD1,
RTL1,
ANXA2R,
NRAS,
VN1R17P,
GPR166P,
RPE65,
LGR6,
CXCL12,
TNFSF10,
TP63,
FZD4,
MBD4,
CD163,
UVRAG,
GDF15,
EFS,
CDC42EP3,
SMR3B,
CKAP4,
TIMP3,
LPAR3,
RASGRP3,
SSTR2,
SST,
SETD2,
SPP1,
SOX10,
SRSF2,
MC1R,
TERT,
FGF2,
GNRH1,
CXCL8,
HTC2,
CXCL10,
CD68,
HSP90AA1,
BRCA1,
MLANA,
PARP1,
EGFR,
FOXO3,
CCR7,
IFNG,
COL11A2,
IDH1,
CD80,
KIF15,
NLRP2,
BTNL2,
DDX43,
LGR4,
MUC13,
SULF2,
KISS1,
CCK,
RUNX1,
PRX,
FBXW7,
CAV1,
SIL1,
SPANXD,
SPANXC,
BRD9,
ZBTB10,
DLK2,
RHPN1-AS1,
TRPM8,
CHAC1,
ABTB1,
ANKRD36B,
CD44,
ZNF654,
SEC14L2,
PRDX3,
RAB31,
CD160,
PSIP1,
CCR6,
PHB2,
TBC1D9,
CDKN2B,
DICER1,
CDKN1B,
BRD4,
RPL13A,
CDKN1A,
CDK9,
PHF10,
CDK7,
CDK2,
B3GAT1,
TMEM97,
CDC25B,
NXT1,
RBM15B,
RMC1,
SPANXA1,
FOXP3,
ANGPTL4,
ADA2,
CCND1,
BMP7,
MAGT1,
LBH,
MIR145,
MIR155,
MIR17,
MIR182,
MIR20A,
MIR216A,
MIR224,
MIR27A,
MIR34A,
MIR34B,
ALPI,
ALCAM,
XRCC6P5,
MIR367,
WG,
JPX,
MIR506,
POU5F1P3,
POU5F1P4,
MIR652,
SPANXA2,
MIR454,
MIR873,
FTX,
MICA,
CENPS-CORT,
PAUPAR,
LOC110806263,
H3P9,
H3P42,
MIR146A,
MIR144,
ARHGAP24,
MIR143,
SESN2,
COX8A,
DNER,
BAX,
AHNAK2,
ADPRHL1,
MIR155HG,
RHPN1,
KCTD12,
BAD,
B2M,
CANT1,
ATM,
RSS,
BTNL9,
CNKSR3,
ARF6,
XIAP,
HOXA11-AS,
APC,
ANGPT2,
CENPS,
ANGPT1,
ALPP,
CASC15,
MIRLET7B,
MIR134,
MIR137,
MIR142,
SUB1,
MRPL28,
USP19,
RNF2,
PMS2,
POU5F1,
IFNA13,
PRKDC,
IFNA1,
LGMN,
ICAM1,
IAPP,
RAD51,
RARB,
REL,
RELB,
RET,
RPS19,
IGF1R,
S100A2,
SCN10A,
HSPG2,
CCL22,
SDCBP,
SDHD,
HLA-G,
SKP2,
SLC2A1,
SNAI2,
SMS,
SOS1,
HLA-A,
PLG,
CCN1,
HK2,
NF1,
KTN1,
LEP,
ITGB2,
MCAM,
MDM2,
RAB8A,
ITGAL,
MGMT,
CIITA,
MLH1,
MMP2,
MYC,
NBN,
NFKB1,
IL1A,
NFKB2,
NGF,
IDO1,
NTRK2,
P2RX7,
PEBP1,
PAK1,
PCNA,
IL2,
SERPINF1,
ABCB1,
IL1RN,
IL1B,
SPARC,
HIC1,
CYSLTR1,
HDAC9,
SQSTM1,
NAE1,
F3,
EZH2,
LATS1,
ATG12,
ERBB2,
MAGI1,
COX5A,
LIPG,
ABCG2,
ATG5,
EDNRB,
HDAC4,
TNFRSF10C,
GAB2,
AKT3,
EIF1,
CTDSPL,
GDF11,
DPYSL2,
WARS2,
DES,
CIB1,
JAG2,
CTNNB1,
CPOX,
NES,
FABP3,
TNFRSF10D,
SSTR1,
TPI1,
GTF2H4,
GRN,
SSTR5,
STAT3,
ADAM17,
TAZ,
ZEB1,
ADAM10,
TFPI,
THBS2,
GNA12,
GLI1,
TP73,
TRIO,
FANCD2,
GFAP,
FTH1P3,
MTOR,
VIM,
TRPV1,
WARS1,
XIST,
SEM1,
MIA,
BRAP,
FKBP4,
LOH19CR1,
IKBKG,
ACTB
Drugs
Registered!
Uveal melanoma is a rare tumor of the eye, arising from the choroid in 90% of cases and from the iris and ciliary body in the other 10% of cases, which clinically presents with visual symptoms (including blurred vision, photopsia, floaters, and visual field reduction), a visible mass and pain. Fatal metastatic disease is seen in about half of all patients, with the liver being the most frequent site of metastasis.