Duodenal Atresia
Mishalany et al. (1970) described 2 children with duodenal atresia, all 4 parents of whom were descendants from one couple related as first cousins. Mishalany et al. (1971) then reported that a third affected child had been born in this kindred. Der Kaloustian et al. (1974) reported yet another affected child. See jejunal atresia (243600). Best et al. (1989) described 2 families: in 1, a son and daughter of unrelated parents were affected; in the second, 2 sons of a consanguineous marriage were affected as well as the daughter of 1 of the affected males. In a 10-year survey of 65 hospitals by the surgical section of the American Academy of Pediatrics, 503 patients were identified with congenital duodenal atresia; 13 instances of intestinal atresia in sibs were found, with 4 sibs affected in 1 family (Fonkalsrud et al., 1969).