Parc Syndrome

Verloes et al. (1990) described a possibly new autosomal dominant syndrome that combined poikiloderma, alopecia, retrognathism, and cleft palate--the PARC syndrome. The family came to attention with the birth of a son who had striking alopecia with absent eyebrows and eyelashes, as well as absent lanugo of other parts of the skin except the scalp. The infant had severe microretrognathism and median posterior cleft palate without glossoptosis. The father, aged 32 years, was in good health and of normal height, but had retrognathism with overbite but no palatal defect. He was almost completely bald.