Renal Medullary Carcinoma

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Retrieved

2022-04-26

Source

Gard

Trials

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Genes

SMARCB1, ALK, MTOR, ABL1, CCND1, MTTP, PTEN, SCT, SMARCA1, VCL, VEGFA, CD274

Drugs

(R, S)-3-(bromomethyl)-3-butanol-1-yl-diphosphate, 26 base single stranded phosphodiester DNA oligonucleotide, 4-amino-5-oxo-4 (pyridinium-1-ylmethyl) proline

(R, S)-3-(bromomethyl)-3-butanol-1-yl-diphosphate, 26 base single stranded phosphodiester DNA oligonucleotide, 4-amino-5-oxo-4 (pyridinium-1-ylmethyl) proline, Aldesleukin ( PROLEUKIN ), Autologous Tumor-Derived gp96 Heat Shock Protein-Peptide Complex ( ONCOPHAGE ), Autologous renal cell tumor vaccine, Axitinib ( INLYTA ), Bevacizumab ( Equidacent, AVASTIN, Aybintio, MVASI ), Everolimus ( AFINITOR, VOTUBIA ), Genetically modified allogeneic (human) tumour cells for the expression of IL-7, GM-CSF, CD80 and CD154, in fixed combination with a DNA-based double stem loop immunomodulator (dSLIM), Girentuximab ( RENCAREX ), HLA class I/II binding tumour associated peptides (ADF-APO-CCN-GUC-K67-MET-MMPMMPMUC-RGS), Human interleukin-2 (glycosylated tetrasaccharide, glycosylated trisaccharide and nonglycosylated) (inhalation use), Humanized anti-KSA monoclonal antibody-human interleukin-2 fusion protein, Interferon gamma 1b ( ACTIMMUNE, IMUKIN ), Iodine (131I) chimeric IgG monoclonal antibody cG250, N-{2-Chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl}-N'-(5-methyl-3-isoxazolyl) urea hydrochloride monohydrate, Naptumomab estafenatox, Pazopanib hydrochloride ( VOTRIENT ), Recombinant human interleukin-21, Recombinant modified vaccinia Ankara expressing human 5T4, Siltuximab ( SYLVANT ), Sorafenib tosylate ( NEXAVAR ), Sunitinib malate ( SUTENT ), Talactoferrinum alfa, Temsirolimus ( TORISEL )

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Renal medullary carcinoma is a rare kidney cancer that mostly affects young people with African ancestry. The tumor develops in the medulla of the kidney. The first sign is often blood in the urine (hematuria). Patients may also develop flank pain or feel a lump in the abdomen that is usually on the right side of the body. Having sickle cell trait is a risk factor for developing renal medullary carcinoma. Treatment options include surgery to take out part or all of the kidney (radical nephrectomy), chemotherapy, and palliative radiation therapy. In most cases, the disease is advanced when the diagnosis is made and has spread to other parts of the body (metastasis).