Hansen's Disease
Watchlist
Retrieved
2022-04-26
Source
Trials
—
Genes
CCDC88B,
SLC11A1,
TLR2,
TLR1,
IL23R,
RAB32,
BATF3,
LTA,
HLA-DRB1,
LACC1,
CCDC122,
TNFSF15,
C1orf141,
HLA-B,
PRKN,
TNF,
RIPK2,
SIGLEC5,
IL18R1,
IL10,
IL1RL1,
LINC02571,
DELEC1,
FILIP1,
BBS9,
COX4I1,
CDH18,
SLC2A13,
RMI2,
SNX20
CCDC88B,
SLC11A1,
TLR2,
TLR1,
IL23R,
RAB32,
BATF3,
LTA,
HLA-DRB1,
LACC1,
CCDC122,
TNFSF15,
C1orf141,
HLA-B,
PRKN,
TNF,
RIPK2,
SIGLEC5,
IL18R1,
IL10,
IL1RL1,
LINC02571,
DELEC1,
FILIP1,
BBS9,
COX4I1,
CDH18,
SLC2A13,
RMI2,
SNX20,
LINC01091,
WASF5P,
UBE2V1P15,
LINC00690,
IFNG,
NOD2,
VDR,
LRRK2,
SDHD,
PACRG,
IL6,
MBL2,
RBM45,
TLR4,
MICA,
ERBB2,
IL4,
IL12B,
BTNL2,
HLA-A,
HSPD1,
HLA-DQA1,
IL2,
GEM,
S100A6,
DDX39A,
SLC26A3,
MRC1,
NGF,
CFP,
CCL4,
CFH,
DDX39B,
TOLLIP,
TGFBR2,
KIR3DL1,
CTLA4,
IL17F,
SLC7A9,
IL2RA,
HSD11B2,
APOE,
IL1B,
IL10RB,
CXCL10,
IL17A,
IL12RB2,
BCHE,
CD209,
ACTG2,
IL22,
CCR2,
TOR1B,
FOXP3,
NT5C3A,
POTEM,
CD274,
IL37,
CYP2E1,
PARL,
CYP19A1,
ACAD8,
RNU1-1,
NUPR1,
H3C9P,
SPAG8,
PTPN22,
NLRP1,
ACOT7,
ACTG1,
POTEKP,
EMC3,
CR1,
ADGB,
PWAR1,
CASP8,
APOA1,
STING1,
CD14,
TNFSF8,
CD40,
IRGM,
TIRAP,
CD40LG,
DEFB1,
ACTBL2,
IL26,
GAL3ST4,
SLC52A2,
PINK1,
CCR5,
ANXA2,
ZNF410,
HAMP,
MAVS,
AKR1B10,
ANXA1,
FMNL1,
HLA-DQB1,
SOCS1,
MASP2,
MFN2,
PCK1,
HIF1A,
PAEP,
NOS2,
NFKBIL1,
MPZ,
MNAT1,
MICB,
CIITA,
LTB,
LGALS3,
LDLR,
KIR3DL2,
KIR2DS1,
KDR,
ISG20,
IL15,
IL13RA1,
IL13,
IL10RA,
HLA-C,
CXCR2,
IL5RA,
IL1RN,
IL1A,
IGF1,
HSPE1,
POLG,
PREP,
RNU1-4,
FLNA,
BMS1,
FHL5,
IL32,
MAP3K14,
BCL10,
NR1I2,
F2R,
FCN1,
FCN2,
HLA-DRB4,
FCN3,
VEGFA,
TOP2A,
S100A1,
CXCR3,
GSTM1,
TGFBR1,
TGFB1,
TFAM,
TAP1,
STAT3,
SOD2,
SLAMF1,
ACACA,
CCL3,
S100B,
SERPINA3
Drugs
Clofazimine
(
LAMPREN,
LAMPRENE
),
Ofloxacin
(
TARIVID
),
Rifampicin
(
APTECIN,
RIFADIN,
RIFADINE,
RIMACTANE
)
Clofazimine
(
LAMPREN,
LAMPRENE
),
Ofloxacin
(
TARIVID
),
Rifampicin
(
APTECIN,
RIFADIN,
RIFADINE,
RIMACTANE
),
Thalidomide
(
THALIDOMIDE CELGENE,
THALOMID
)
Registered!
Hansen's disease (also known as leprosy) is a rare bacterial infection that affects the skin, nerves and mucous membranes. After exposure, it may take anywhere from 2 to 10 years to develop features of the condition. Once present, common signs and symptoms include skin lesions; muscle weakness or paralysis; eye problems that may lead to blindness; nosebleeds; severe pain; and/or numbness in the hands, feet, arms and legs. Hansen's disease is caused by the bacterium Mycobacterium leprae; however, the way in which the bacterium is transmitted (spread) is poorly understood. It appears that only about 5% of people are susceptible to the condition. Hansen's disease is easily treated with combination antibiotics for 6 months to 2 years.