Igg4-Related Skin Disease
IgG4-related skin disease is the recommended name for skin manifestations in IgG4-related disease (IgG4-RD). Multiple different skin manifestations have been described.
Classification
Although a clear understanding of the various skin lesions in IgG4-related disease is a work in progress, skin lesions have been classified into subtypes based on documented cases:
- Angiolymphoid hyperplasia with eosinophilia (or lesions that mimic it) and cutaneous pseudolymphoma
- Cutaneous plasmacytosis
- Eyelid swelling (as part of Mikulicz's disease)
- Psoriasis-like eruptions
- Unspecified maculopapular or erythematous eruptions
- Hypergammaglobulinemic purpura and urticarial vasculitis
- Impaired blood supply to fingers or toes, leading to Raynaud's phenomenon or gangrene
In addition, Wells syndrome has also been reported in a case of IgG4-related disease.
Note:
- ^ Some do not consider cutaneous plasmacytosis to be a feature of IgG4-related disease for reasons that include: a lack of systemic features, no response to steroid therapy and a different histological pattern.
See also
- IgG4-related disease