Early-Onset Non-Syndromic Cataract
Watchlist
Retrieved
2021-01-23
Source
Trials
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Genes
CRYBB3,
CRYAA,
CRYBA2,
CRYGB,
IL6,
CRP,
HSF4,
COL4A3,
IL10,
ACE,
COPD,
KLK3,
TNF,
HMGB1,
CXCL8,
ALB,
PROS1,
PSAT1,
TIMP1,
MBL2,
MMP9,
SLC2A10,
CXCL10,
NPEPPS,
PLAG1,
IRF5,
IL1B,
IL1RN,
MIR184,
TLR4
CRYBB3,
CRYAA,
CRYBA2,
CRYGB,
IL6,
CRP,
HSF4,
COL4A3,
IL10,
ACE,
COPD,
KLK3,
TNF,
HMGB1,
CXCL8,
ALB,
PROS1,
PSAT1,
TIMP1,
MBL2,
MMP9,
SLC2A10,
CXCL10,
NPEPPS,
PLAG1,
IRF5,
IL1B,
IL1RN,
MIR184,
TLR4,
AR,
CHI3L1,
SFTPD,
PTX3,
BTBD8,
CCL18,
COL4A5,
VDR,
TNFRSF1B,
TP53,
ARTN,
VEGFA,
TIMELESS,
RNGTT,
IKBKG,
CSRP3,
VIP,
ARHGEF5,
A2M,
FGF21,
SMC3,
NDRG1,
AK6,
SFTPA2,
SFTPA1,
MIR384,
MIR222,
MIR146A,
CRIP3,
EPHA6,
CTAG1A,
DCD,
NLRP3,
BIRC8,
MLIP,
ACKR3,
TMCO3,
TLR9,
PCA3,
HAVCR1,
SLC17A5,
SPATS2L,
GABARAPL1,
HEY2,
SLC9A6,
TLR2,
SERPINE1,
TGM2,
TAT,
FCGR2A,
FAAH,
ERBB3,
EGFR,
DPP4,
DDX3X,
CYP1A1,
CTAG1B,
CCR5,
CEBPD,
CDKN2A,
CD28,
CAMP,
BGLAP,
BDNF,
BCL2,
BCHE,
AVP,
ARG1,
APOB,
ANXA11,
FCGR3A,
FCGR3B,
FCN2,
MEFV,
SPP1,
SMPD1,
SLC7A4,
SFTPB,
SDC4,
CCL22,
PTPRC,
ADM,
MUC1,
KRAS,
FGF1,
INSRR,
IL13,
IL1A,
IGHG1,
IFNG,
TNC,
HOXB7,
GRN,
FGF2,
H3P10
Drugs
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Registered!
A rare, genetic, non-syndromic developmental defect of the eye disorder, with high clinical and genetic heterogeneity, most frequently characterized by bilateral, symmetrical, non-progressive cataracts which present at birth or in early-childhood. Additional ocular manifestations (e.g. anterior segment dysgenesis, colobomas, nystagmus, microcornea, microphthalmia, myopia) may be associated, however other organs/systems are usually not affected.