Early-Onset Non-Syndromic Cataract
Watchlist
            
          Retrieved
            2021-01-23
          Source
            
          Trials
            
                —
              
            Genes
            
                  
                  CRYBB3, 
                  CRYAA, 
                  CRYBA2, 
                  CRYGB, 
                  IL6, 
                  CRP, 
                  HSF4, 
                  COL4A3, 
                  IL10, 
                  ACE, 
                  COPD, 
                  KLK3, 
                  TNF, 
                  HMGB1, 
                  CXCL8, 
                  ALB, 
                  PROS1, 
                  PSAT1, 
                  TIMP1, 
                  MBL2, 
                  MMP9, 
                  SLC2A10, 
                  CXCL10, 
                  NPEPPS, 
                  PLAG1, 
                  IRF5, 
                  IL1B, 
                  IL1RN, 
                  MIR184, 
                  TLR4
                
                
                  
                  CRYBB3, 
                  CRYAA, 
                  CRYBA2, 
                  CRYGB, 
                  IL6, 
                  CRP, 
                  HSF4, 
                  COL4A3, 
                  IL10, 
                  ACE, 
                  COPD, 
                  KLK3, 
                  TNF, 
                  HMGB1, 
                  CXCL8, 
                  ALB, 
                  PROS1, 
                  PSAT1, 
                  TIMP1, 
                  MBL2, 
                  MMP9, 
                  SLC2A10, 
                  CXCL10, 
                  NPEPPS, 
                  PLAG1, 
                  IRF5, 
                  IL1B, 
                  IL1RN, 
                  MIR184, 
                  TLR4, 
                  AR, 
                  CHI3L1, 
                  SFTPD, 
                  PTX3, 
                  BTBD8, 
                  CCL18, 
                  COL4A5, 
                  VDR, 
                  TNFRSF1B, 
                  TP53, 
                  ARTN, 
                  VEGFA, 
                  TIMELESS, 
                  RNGTT, 
                  IKBKG, 
                  CSRP3, 
                  VIP, 
                  ARHGEF5, 
                  A2M, 
                  FGF21, 
                  SMC3, 
                  NDRG1, 
                  AK6, 
                  SFTPA2, 
                  SFTPA1, 
                  MIR384, 
                  MIR222, 
                  MIR146A, 
                  CRIP3, 
                  EPHA6, 
                  CTAG1A, 
                  DCD, 
                  NLRP3, 
                  BIRC8, 
                  MLIP, 
                  ACKR3, 
                  TMCO3, 
                  TLR9, 
                  PCA3, 
                  HAVCR1, 
                  SLC17A5, 
                  SPATS2L, 
                  GABARAPL1, 
                  HEY2, 
                  SLC9A6, 
                  TLR2, 
                  SERPINE1, 
                  TGM2, 
                  TAT, 
                  FCGR2A, 
                  FAAH, 
                  ERBB3, 
                  EGFR, 
                  DPP4, 
                  DDX3X, 
                  CYP1A1, 
                  CTAG1B, 
                  CCR5, 
                  CEBPD, 
                  CDKN2A, 
                  CD28, 
                  CAMP, 
                  BGLAP, 
                  BDNF, 
                  BCL2, 
                  BCHE, 
                  AVP, 
                  ARG1, 
                  APOB, 
                  ANXA11, 
                  FCGR3A, 
                  FCGR3B, 
                  FCN2, 
                  MEFV, 
                  SPP1, 
                  SMPD1, 
                  SLC7A4, 
                  SFTPB, 
                  SDC4, 
                  CCL22, 
                  PTPRC, 
                  ADM, 
                  MUC1, 
                  KRAS, 
                  FGF1, 
                  INSRR, 
                  IL13, 
                  IL1A, 
                  IGHG1, 
                  IFNG, 
                  TNC, 
                  HOXB7, 
                  GRN, 
                  FGF2, 
                  H3P10
                
                
              Drugs
            
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            Registered!
                A rare, genetic, non-syndromic developmental defect of the eye disorder, with high clinical and genetic heterogeneity, most frequently characterized by bilateral, symmetrical, non-progressive cataracts which present at birth or in early-childhood. Additional ocular manifestations (e.g. anterior segment dysgenesis, colobomas, nystagmus, microcornea, microphthalmia, myopia) may be associated, however other organs/systems are usually not affected.