Diffuse Large B-Cell Lymphoma
Watchlist
Retrieved
2021-01-23
Source
Trials
—
Genes
EZH2,
MYD88,
CARD11,
PIK3CD,
CD79B,
CD79A,
PRDM1,
CD274,
PIK3CG,
MYC,
CDKN2A,
PIK3CA,
ALK,
PIK3CB,
ABCB1,
BCL2,
MALT1,
CREBBP,
EP300,
JAK2,
FAS,
FOXO1,
GLI1,
B2M,
KMT2D,
ABCG2,
CDK2,
RPS6KB1,
GNA13,
STAT6
EZH2,
MYD88,
CARD11,
PIK3CD,
CD79B,
CD79A,
PRDM1,
CD274,
PIK3CG,
MYC,
CDKN2A,
PIK3CA,
ALK,
PIK3CB,
ABCB1,
BCL2,
MALT1,
CREBBP,
EP300,
JAK2,
FAS,
FOXO1,
GLI1,
B2M,
KMT2D,
ABCG2,
CDK2,
RPS6KB1,
GNA13,
STAT6,
CDK1,
IRF8,
FBXO11,
IKZF1,
NOTCH2,
SKP2,
CLTC,
PDPK1,
PRDM11,
RANGAP1,
NECTIN2,
SOD2,
SGK1,
SOD3,
NOM1,
PRDX3,
SPEN,
CAT,
TRAF5,
TP53,
TXNIP,
BCAS2,
SEC31A,
CCDC86,
PRDX4,
IMMP2L,
SMURF2,
HLA-B,
CD86,
SMUG1,
PWWP3A,
TNFRSF8,
ARAP3,
MIR34A,
GBA,
NCOA5,
BCL10,
AICDA,
DDIT3,
CDC42BPB,
FOXP1,
RTEL1,
IGH,
MIR155,
NPR2,
NOS2,
TNF,
KRT20,
TNPO2,
STAT3,
MIR21,
LMO2,
NOS1,
AKT1,
SYK,
CCND1,
KALRN,
CXCR4,
MCL1,
MME,
IGHV3-69-1,
PVT1,
MMEL1,
MGMT,
IL10,
IRF4,
BTK,
DLEU1,
ATM,
ABCB6,
BCL6,
CD19,
MS4A1,
FCGR3A,
LOC102723407,
H3P10,
PAX5,
PRKAR1A,
PTEN,
IL6,
LOC102724971,
SPG7,
CXADR,
ARR3,
FOXP3,
CASR,
PDLIM7,
TRIM13,
NR1I3,
BIRC3,
NFKB1,
CXADRP1,
IL2,
CCND2,
CD40,
SOAT1,
TCL1A,
MEF2B,
REL,
MET,
GSTP1,
MCTS1,
PDE4B,
PDCD1,
SLC16A1,
CDKN1B,
PDCD1LG2,
PIM1,
IGHV3OR16-7,
HDAC9,
IL4,
HDAC6,
SDC1,
DNER,
TBC1D9,
MCAT,
MDM2,
ALB,
CDKN2B,
CDR3,
TNFAIP3,
TCL1B,
HTC2,
CMA1,
MTHFR,
CCND3,
ZC3H12D,
DAPK1,
WEE1,
VEGFA,
TP63,
CTNNB1,
MIR17HG,
GCSAM,
CD44,
CD38,
PLK1,
GSTT1,
PTPN6,
GSTM1,
FHIT,
MAPK3,
ERCC2,
MAPK1,
MTOR,
CDK4,
BCL3,
SOCS1,
SMAD1,
CASP3,
LTA,
XBP1,
CD22,
TNFSF13B,
LAIR1,
KMT2B,
TET2,
BCL2A1,
BACH2,
IFNG,
CD163,
S1PR2,
LIG4,
IL21,
MIR15A,
HSP90AA1,
NFKB2,
PARP9,
CDK9,
KRAS,
UHMK1,
MTA3,
POU2F2,
IL21R,
PDE4A,
MLH1,
JAK1,
ACKR3,
MKI67,
HIF1A,
KMT2A,
MIR155HG,
MTX1,
MUC1,
NEK2,
NRAS,
HLA-DRB1,
KLHL6,
HLA-C,
NCAM1,
LGALS1,
CDKN1C,
CXCL12,
SERPINA9,
BCR,
SLC22A2,
ARID1A,
LOC390714,
CUX1,
SOX11,
CIB1,
SPIB,
SPN,
SPP1,
MRPL28,
CR2,
CASP1,
TPX2,
CCK,
TRBV20OR9-2,
CHEK2,
FOXM1,
MIR224,
SUB1,
CD37,
TXN,
SIRT1,
CD58,
H3P9,
PTPN1,
EPHB2,
NXT1,
FCGR2A,
PTPRC,
LOC105379528,
SART3,
RHOH,
CES2,
PARP1,
CCL2,
CCL5,
APC,
MSH3,
WRN,
MIB1,
LPP,
EZR,
VIM,
MTAP,
SLC16A4,
UVRAG,
DCTN6,
SLC16A3,
XPO1,
MBTPS1,
XRCC1,
PRMT5,
MAL,
EBI3,
CFLAR,
EFS,
UCHL1,
MAD2L1,
LYN,
EXOC2,
MDM4,
SOCS3,
ZNRD2,
HIP1R,
ZAP70,
MTA1,
DIABLO,
PRKCB,
TYMS,
HPGDS,
SLC19A1,
PMEL,
BRD4,
CRBN,
SCT,
IBTK,
RPE65,
SND1,
RFC1,
PLCG2,
MXI1,
IRAK4,
PTPRO,
TMED7,
POLD1,
POU2AF1,
PTPN2,
IGK,
IL22,
PSMD9,
PCNA,
SLPI,
ABL2,
SMO,
TRAF6,
TRAF3,
NR2C2,
TP73,
CKAP4,
NFATC1,
NFE2L2,
PSIP1,
NME1,
ZEB1,
MAP3K7,
KDM6B,
TLR9,
STAT1,
ACSBG1,
NOTCH1,
ROR1,
OAS3,
SPI1,
SLC7A4,
SMARCA4,
LGALS3,
GRN,
FKBP4,
CCNE1,
CASP9,
FLT1,
MIR497,
GABPA,
GAPDH,
C1QA,
ANTXR2,
GNA12,
GOT2,
TNFRSF13C,
GPX4,
BTG1,
HSPA4,
GTF2H4,
GZMB,
H2AX,
BRCA1,
MTDH,
HK2,
BPI,
HLA-DQB1,
HMGB1,
HAVCR2,
TMED7-TICAM2,
BDNF,
NR4A1,
FCGR3B,
FASN,
ETS1,
CD28,
CRP,
CSF2,
MIR146A,
MIRLET7B,
MALAT1,
MIR17,
MIR195,
TICAM2,
DNMT1,
DNMT3A,
MIR214,
E2F1,
MIR223,
EIF4B,
CDKN1A,
EIF4E,
MIR23A,
EIF4EBP1,
CDH1,
MIR31,
CD70,
ERCC5,
BTLA,
DTX3L,
ESR2,
CD36,
ETFA,
OPN1SW,
MIR142,
ASCC2,
PPP1R2C,
IL2RA,
IL4R,
CXCL8,
IL10RA,
ID3,
IL17A,
VTCN1,
BIRC5,
IRF1,
ISG20,
RAPH1,
ITGAX,
ITPR2,
H3P23,
H3P42,
ADA,
KDR,
ACVRL1,
GAS5,
LAG3,
LAMC2,
LBR,
ACTB,
ATP7A,
TNFRSF9,
ATR,
BCL2L2-PABPN1,
BCL2L2,
IFI27,
HDAC4,
IL24,
WIF1,
RASSF1,
MIR221,
CORO1A,
GLMN,
IL1RAPL1,
MIR222,
CCR2,
PIM2,
BCL2L10,
METAP2,
H3P47,
TNIP1,
COPS5,
SH3BP5,
MIR25,
MIR27A,
MIR27B,
MELK,
MIR28,
MIR22,
VSIG4,
CD300A,
SNHG16,
NCR2,
RCOR1,
AIM2,
PASK,
MIR145,
RAD50,
LINC01672,
MIR150,
MIR16-1,
SPART,
KDM1A,
MIR30A,
MAP4K4,
MIR1234,
MIR197,
MLXIP,
BCL2L11,
MIR200C,
SYCE1L,
MIR210,
PHB2,
HOTAIR,
MIR29C,
NAPSA,
POTEF,
MIR33A,
MIR494,
RACK1,
RBCK1,
NCOR2,
AHSA1,
CCT4,
MIR504,
CXCL13,
SNHG14,
MIR4638,
POU5F1P3,
TP53COR1,
ANP32B,
YAP1,
BATF,
POU5F1P4,
PANDAR,
MIR144,
USP34,
HULC,
D2HGDH,
CIB2,
MAD2L2,
LUNAR1,
MIR146B,
NCOR1,
KEAP1,
BAG3,
HSPH1,
MASP2,
WARS2,
MNS16A,
MIR99A,
MTCO2P12,
MIR135B,
LRP1-AS,
NPM3,
MTSS1,
SMAD5-AS1,
BCLAF1,
MIR148B,
CXCR6,
MIR328,
MIR431,
PRDX6,
MIR323B,
MIR451A,
MIR511,
WTAP,
LINC00273,
NEAT1,
MDN1,
KDM2B,
MAP3K20,
BCL11A,
IL17D,
FCRLA,
PRKAG3,
RIPK4,
GLIS2,
MIR127,
MIXL1,
FSD1L,
ARHGAP24,
PARP14,
LY6K,
DOHH,
ORAI1,
IL23A,
CHRDL1,
UCHL5,
NAPRT,
C1RL,
MZB1,
CGB5,
FOXP2,
CGB8,
PRRT2,
LEF1,
CARD16,
RMDN1,
ASCC1,
RASGRP4,
MSI2,
FCRL4,
DOCK8,
TRPM4,
EAF2,
KLHL1,
PCDH10,
GRAP2,
SLC5A7,
NDRG2,
NSD1,
GMCL1,
PCBP4,
GORASP1,
P2RY12,
WNK1,
MYDGF,
LMO3,
FSD1,
PAG1,
MAP1LC3B,
MORC4,
CCAR1,
RNF34,
NLRP2,
SYBU,
MEG3,
LAPTM4B,
FBXW7,
RMDN3,
TUG1,
ELL3,
MPIG6B,
DEFB126,
PGPEP1,
IL31RA,
F11R,
SLCO6A1,
SIRT3,
CNRIP1,
FOXK1,
CNOT6L,
RNF19A,
SSBP2,
IL27,
AMACR,
PATZ1,
NUTM1,
SLAMF7,
LOC283177,
PRAME,
LYPD5,
FIRRE,
ILDR1,
TES,
EIF4E3,
DICER1,
TSPAN33,
ZACN,
GSTK1,
SLC27A1,
CRTC1,
TMEM189,
TMEM189-UBE2V1,
NEDD4L,
SIK2,
MIRLET7G,
MIR10A,
MIR125A,
POLDIP2,
PHGDH,
PPARGC1B,
COMMD1,
ADGRE2,
CD109,
PASD1,
HT,
VPREB3,
BLNK,
IL34,
LGALS13,
MYLIP,
PYCARD,
APCDD1,
LYPD4,
LGALS16,
SETD2,
IGHV3-23,
CKAP2,
IGHV3-52,
RMDN2,
IGHV4-34,
EML4,
SGSM3,
NKX6-3,
UBR1,
CRTC2,
AGO2,
KLHDC8B,
MORC1,
MARCHF8,
RASGEF1A,
HAVCR1,
CXCL16,
NAT2,
KL,
GCLC,
FLI1,
FN1,
FOS,
FOSB,
KDSR,
XRCC6,
GATA2,
GATA3,
GEM,
GLI2,
LIF,
GPI,
XCR1,
MKNK2,
GPX1,
NR3C1,
GSTA1,
GUCA1B,
HDAC2,
HELLS,
FBP1,
FABP7,
ETV6,
ETV5,
ATN1,
DUSP4,
DVL3,
S1PR1,
EFNA5,
EFNB2,
EGF,
EGR3,
EIF4A1,
EIF4A2,
ELAVL2,
ELF3,
ENO2,
EPHA4,
EPHX1,
EPO,
ERG,
ERN1,
ESR1,
HGF,
HIC1,
HLA-DQA1,
IL9,
IL13,
IDO1,
CXCL10,
INPP5D,
IRAK1,
IRF2,
ISL1,
ITGAM,
ITPR1,
ITPR3,
JAK3,
JUN,
JUNB,
JUND,
KIF2A,
KIR3DL1,
LAMP1,
LCK,
LEP,
IL10RB,
IL1B,
HLA-G,
IL1A,
HLX,
HMMR,
HMOX1,
HNMT,
HNRNPK,
TLX1,
HSPA8,
MRPL58,
IDH1,
IDH2,
IFNA1,
IFNA13,
IFNB1,
IGF1,
IGHA1,
IGHM,
JCHAIN,
IGL,
IKBKB,
DPP4,
DOCK2,
DNMT3B,
BLK,
BMI1,
BMP6,
BRAF,
BRCA2,
BUB1B,
BYSL,
TSPO,
SERPING1,
CACNA1C,
CALD1,
CALR,
CASP8,
RUNX3,
CCNH,
CCNT1,
CD247,
CD5,
CD14,
CD27,
CXCR5,
BIK,
CD59,
BGN,
ABO,
ADAM10,
AHR,
ALDH1A1,
AMCN,
AMPD1,
ANXA5,
APAF1,
XIAP,
APP,
APRT,
RHOA,
ARNT,
STS,
ATF3,
BAX,
BCL2L1,
BCL7A,
NBEAP1,
CD47,
CD63,
NQO1,
CCR8,
CNC2,
CNP,
COL3A1,
CRK,
CRY1,
MAPK14,
CSE1L,
CSF1R,
CSF3,
CSNK2B,
CTLA4,
CX3CR1,
CYBA,
CYP1A1,
CYP17A1,
CYP24A1,
DAP,
DAXX,
DCK,
ABCC2,
CCR7,
CD68,
CCR1,
CD74,
CD81,
ADGRE5,
CDC20,
CDC25C,
CDH11,
CDH13,
CDK3,
CDK5,
CDK6,
CDS1,
CEBPA,
CGA,
CGB3,
CHEK1,
FOXN3,
CHGB,
CHM,
CLU,
LEPR,
LMNA,
SLIT2,
UBE2V1,
TNFRSF1B,
TOP1,
TOP2A,
TP53BP1,
TP53BP2,
TPM3,
TPT1,
UBA52,
UBE2N,
UCN,
LMNB1,
UGCG,
UMOD,
VAV1,
WARS1,
YY1,
ZNF134,
ZBTB17,
PRDM2,
BTG2,
TMSB4X,
TLR1,
TLE1,
NKX2-1,
SPARC,
SPRR1A,
SRM,
STAT5A,
STAT5B,
STIM1,
SYN2,
SYT1,
TAP2,
TAT,
TCF4,
TCF7,
TRA,
TRB,
TRG,
TFF3,
TGFB1,
TGFBR1,
THOP1,
BAG6,
AIMP2,
ARHGEF5,
TNFRSF14,
FADD,
TNFRSF10B,
HDAC3,
CDK5R1,
PER3,
PER2,
ARHGEF7,
SPHK1,
TIMELESS,
MBD2,
BTRC,
P4HA2,
NOL3,
MAP3K14,
AIP,
PIAS2,
USP14,
CD83,
RPL23,
TNFRSF6B,
TNFSF10,
NR4A3,
TNFSF13,
MLLT10,
HMGA2,
CLLS2,
USP11,
USP9X,
SMC1A,
PICALM,
CDC7,
SPOP,
NR0B2,
CUL4B,
OGT,
CAMK1,
MKNK1,
RFXANK,
NCOA1,
EIF4G3,
EED,
RIPK1,
SOX2,
SNAP25,
SLC8A1,
NBN,
NEDD8,
NFATC2,
NFE2L1,
NGF,
NODAL,
NOTCH3,
NPM1,
NRF1,
NT5E,
NTRK1,
P2RY1,
SERPINB2,
PCYT1A,
PDK1,
PECAM1,
PHB,
PLAGL1,
PLG,
PLOD2,
NCL,
MTRR,
POLA1,
MTR,
LPL,
LRMP,
SH2D1A,
MXD1,
SMAD5,
MAP4,
MBP,
MC1R,
BORCS8-MEF2B,
MFAP1,
CIITA,
CD99,
CXCL9,
FOXO4,
ABCC1,
MSH2,
MSN,
MST1R,
COX2,
PMAIP1,
POU5F1,
SIAH1,
RDX,
RELB,
RGS1,
RNASEL,
BRD2,
RPS6,
RPS6KA1,
RPS6KA2,
RPS6KA3,
RPS20,
RREB1,
S100A8,
CCL3,
CCL4,
CCL13,
CCL18,
CCL22,
SELL,
SELPLG,
SET,
RELA,
OPN1LW,
PPA1,
RBL1,
PTPA,
PPP2R5E,
PRKAA2,
PRKCA,
MAPK11,
MAP2K7,
LGMN,
PSMB5,
PSMB9,
PTH,
PTGS2,
PTMS,
PTPN13,
PTPRD,
PTPRJ,
RAD1,
RAD23B,
RAD51,
RARA,
H3P40
Drugs
3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione hydrochloride,
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus
3-(5-amino-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione hydrochloride,
5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine,
Allogeneic multi-virus specific T lymphocytes targeting BK virus, cytomegalovirus, human herpesvirus-6, Epstein Barr virus and adenovirus,
Autologous CD4+ and CD8+ T cells expressing a CD19-specific chimeric antigen receptor,
Autologous Epstein-Barr virus specific T cells derived from peripheral blood mononuclear cells, expanded ex vivo-,
Autologous engineered anti -CD19 Chimeric Antigen Receptor (CAR +) T -cells
(
KYMRIAH
),
Axicabtagene ciloleucel
(
YESCARTA
),
Brentuximab vedotin
(
ADCETRIS
),
Enzastaurin hydrochloride,
Everolimus
(
AFINITOR,
VOTUBIA
),
Humanised Fc engineered monoclonal antibody against CD19,
Humanised anti-CD37 monoclonal antibody conjugated to maytansinoid DM1,
Ibrutinib
(
IMBRUVICA
),
Iodine (131I) tositumomab,
Lenalidomide
(
LENALIDOMIDE ACCORD,
REVLIMID
),
Mocetinostat,
Obinutuzumab
(
GAZYVA,
GAZYVARO
),
Pixantrone dimaleate
(
PIXUVRI
),
Polatuzumab vedotin
(
POLIVY
),
Pralatrexate
(
FOLOTYN
),
Recombinant histidine-tagged idiotype immunoglobulin Fab fragment of clonal B-cell receptors,
Rituximab
(
BLITZIMA,
MABTHERA,
TRUXIMA,
RITEMVIA,
RITUXAN,
RITUZENA,
RIXATHON,
RIXIMYO,
Ruxience
),
Selinexor
(
XPOVIO
),
Tazemetostat
(
TAZVERIK
),
Valproic acid, sodium,
Venetoclax
(
VENCLEXTA,
VENCLYXTO
),
haematopoietic stem cells and blood progenitors umbilical cord-derived expanded with (1R, 4R)-N1-(2-benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine dihydrobromide dihydrate
Registered!
Diffuse large B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma (NHL; see this term) in adults characterized by a median age of presentation in the sixth decade of life (but also rarely occurring in adolescents and children) with the initial presentation being single or multiple rapidly growing masses (that may or may not be painful) in nodal or extranodal sites (such as thyroid, skin, breast, gastrointestinal tract, testes, bone, or brain) and that can be accompanied by symptoms of fever, night sweats and weight loss. DLBCL has an aggressive disease course, with the elderly having a poorer prognosis than younger patients, and with relapses being common.