Kaposi Sarcoma
Watchlist
Retrieved
2022-04-26
Source
Trials
—
Genes
IL6,
GPR42,
TNFRSF4,
ADRA1A,
LPAR2,
ACKR3,
MRGPRF,
EDNRA,
CXCR6,
TP53,
BRS3,
BCL2,
SSTR4,
ADRA2B,
PCNA,
RBFOX2,
VEGFA,
HIF1A,
CASP8,
WDR19,
SHISA8,
TAT,
IL1B,
IRF4,
IFNA1,
FLT4,
ANGPT2,
RAC1,
CXCL8,
STAT3
IL6,
GPR42,
TNFRSF4,
ADRA1A,
LPAR2,
ACKR3,
MRGPRF,
EDNRA,
CXCR6,
TP53,
BRS3,
BCL2,
SSTR4,
ADRA2B,
PCNA,
RBFOX2,
VEGFA,
HIF1A,
CASP8,
WDR19,
SHISA8,
TAT,
IL1B,
IRF4,
IFNA1,
FLT4,
ANGPT2,
RAC1,
CXCL8,
STAT3,
FGF2,
FAM120C,
IFNA13,
PROX1,
MLYCD,
MUC1,
MYC,
PECAM1,
CASP3,
KDR,
AGRP,
DLL4,
KIT,
TNF,
HMOX1,
CXCR4,
PTGS2,
HLA-C,
CD274,
CDK6,
ARTN,
GPR166P,
EPHA2,
GPR151,
VN1R17P,
IRF3,
TLR4,
IL1A,
MTOR,
BCL6,
MRGPRX3,
CXCR2,
LPAR3,
FCGR3A,
FZD4,
MRGPRX4,
GPRC6A,
OXER1,
PIK3CD,
PIK3CG,
IKBKE,
CTCF,
XBP1,
CDKN1B,
HLA-B,
MDM2,
HLA-A,
SLK,
PIK3CB,
AR,
LGR6,
PIK3CA,
CTNNB1,
STAT6,
NR3C1,
MRGPRX1,
RBP4,
SUGP1,
RBPJ,
INTS2,
RENBP,
IFNB1,
ANOS1,
IL4,
IL6ST,
LYVE1,
NM,
ANGPTL4,
PDPN,
MKI67,
MIP,
POMC,
MBL2,
ADA2,
KRT20,
LGALS1,
KRT15,
MUL1,
MAPK1,
NFE2L2,
ITGB3,
IRF7,
IRF5,
INSR,
TRIM28,
LRPPRC,
NPM1,
IL10,
FSD1,
CLIP2,
MAP4K4,
EPHB2,
EPHA1,
EIF4E,
EFNB2,
EDNRB,
EDN1,
CBLL2,
SIGLEC1,
CREB1,
MIR126,
CCR5,
TERT,
MIR155,
CEBPA,
CDKN3,
CDKN1A,
CD40LG,
CD40,
CD34,
CD86,
MS4A1,
USP7,
AKT1,
VEGFC,
CFLAR,
OSM,
FAM107B,
FGF3,
CLIP1,
CCL1,
GBP1,
EPHB4,
H2AX,
HGF,
FSD1L,
SDC1,
SELE,
PRKN,
F13A1,
ETS1,
HLA-DRB1,
EZH2,
H4C1,
H4C8,
ADAMTS1,
PDLIM7,
ZNF629,
IL32,
XPO1,
MSC,
H4C3,
ARC,
ZIC2,
DCTN6,
H4C11,
H4C12,
MALT1,
H4C2,
H4C4,
H4C9,
KLRK1,
H4C6,
RAD50,
H4C5,
AURKB,
FADD,
TNIP1,
SEMA3A,
TNFSF10,
SOCS1,
IKBKG,
NDRG1,
HDAC5,
YAP1,
CACNA1G,
SOCS6,
CIB1,
BCL10,
SEMA7A,
NR0B2,
H4C14,
CLDN2,
KAT5,
H4C13,
ZNRD2,
ARID3B,
NCOA2,
ACTB,
SIRT1,
ZNF569,
MIR140,
MIR125B1,
TMEM189-UBE2V1,
TMEM189,
NDUFS7,
TICAM2,
ZNF763,
OR10A4,
IFNL3,
MPLKIP,
PLVAP,
TRIM43,
RBM45,
H4-16,
CGAS,
UBASH3B,
PWWP3A,
KISS1R,
MAK16,
TCHP,
MIR146A,
MIR21,
MIR30B,
MIR30C1,
MTCO2P12,
RN7SL263P,
IFNL4,
ERVK-20,
KLRC4-KLRK1,
TMX2-CTNND1,
MIR711,
TMED7-TICAM2,
CASTOR2,
CASTOR1,
H4C15,
MIR375,
LNCR1,
BECN2,
MIR17HG,
MIR99A,
MIR34A,
MIR31,
MIR30C2,
CTTNBP2,
UNC93B1,
HEY1,
TMED7,
FBXW7,
TESC,
TLR9,
GDE1,
SIRT6,
TAOK3,
TLR7,
MZB1,
EGFL7,
ERVW-1,
ZNF436,
TNRC6A,
RBMS3,
AGO2,
SND1,
LRIT1,
SMPX,
SLC7A11,
DDX58,
SRRM2,
SHFL,
ZNF331,
FERMT1,
CHD7,
COL18A1,
PDCD1LG2,
TNIP3,
EHMT1,
SHCBP1,
RBM15,
CERK,
ROBO3,
ERVK-6,
MIB1,
AICDA,
PCBP4,
SLC12A9,
PNO1,
SPHK2,
ZNF253,
WT1,
DCP1A,
NLRP2,
PAG1,
OPN1LW,
VDR,
FOXO3,
HP,
HLA-G,
HLA-DQA1,
HDAC1,
CXCL1,
XCR1,
GEM,
GABPA,
FUS,
FOXO1,
ITGB1,
FGFR2,
FGFR1,
FGF5,
FGF4,
PTK2B,
ERG,
EREG,
ERBB2,
EPHA7,
HSPA4,
HSP90AA1,
ICAM1,
ID1,
ITGA5,
IRF2,
IRF1,
IRAK1,
CXCL10,
INHBB,
IDO1,
IL13,
IL12A,
CXCR1,
IL1RN,
IGF2R,
IGF2,
IGF1R,
IGF1,
IFNG,
IFNA2,
IFI27,
IFI16,
EPHA4,
EPAS1,
EIF4EBP1,
CD80,
SERPINH1,
RUNX3,
CAMP,
BUB1,
BSG,
BCR,
OPN1SW,
BCL2L1,
CCND1,
AXL,
ATM,
ASS1,
APEX1,
APBA2,
APBA1,
ANXA6,
ANPEP,
ALB,
JAG1,
CD1D,
TNFRSF8,
EGR1,
CD70,
EGF,
S1PR3,
S1PR1,
RCAN1,
ATN1,
DHFR,
DDX6,
DCN,
CTSB,
CTNND1,
CSHL1,
CREBBP,
CNR2,
CCR6,
CCR3,
CISH,
CEBPB,
CDKN2A,
CDK1,
ITGAV,
KIR2DL2,
VCAM1,
BRD2,
SKP2,
CXCL12,
CCL20,
CCL11,
CCL5,
SCTR,
RREB1,
RPS6KB1,
RPS6KA3,
RNASE2,
KIR3DL1,
RNASE1,
REL,
RECQL,
PLAAT4,
PTX3,
PTPRC,
PTPN6,
PTK2,
PTBP1,
SLC6A3,
SLC12A3,
SLC22A2,
SUMO3,
KDM6A,
UCHL1,
SUMO1,
UBE2V1,
TYRO3,
TYMS,
TNFSF4,
TSC2,
TSC1,
TRAF3,
TNFAIP3,
THBS1,
TGFBR2,
TGFB1,
TEK,
MAP3K7,
SUV39H1,
SSRP1,
SUMO2,
PSMD9,
EIF2AK2,
MAP2K1,
NBN,
COX2,
MT3,
MRE11,
MPO,
MNDA,
MMP14,
MMP13,
MMP7,
MMP2,
MLH1,
MCL1,
LTA,
LRPAP1,
LRP1,
LPA,
LIG4,
LGALS3,
KRAS,
KIR3DS1,
GADD45B,
NCL,
MAPK8,
NEDD8,
PPARG,
POU2F2,
POU2AF1,
PLCG1,
PIN1,
PIK3R2,
PIK3C2A,
PF4V1,
PDGFRB,
PDGFA,
PDCD1,
PAX2,
PAM,
NTRK1,
NOS3,
NME1,
NFKB1,
NFATC2,
NEUROG1,
H3P23
Drugs
(-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1yl)-4-(1H-indol-3-yl) pyrrolidine-2, 5-dione,
(1-methyl-2-nitro-1H-imidazole-5-yl)methyl N,N'-bis(2-bromoethyl) diamidophosphate,
16-base single-stranded peptide nucleic acid oligonucleotide linked to a 7-amino acid peptide
(-)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1yl)-4-(1H-indol-3-yl) pyrrolidine-2, 5-dione,
(1-methyl-2-nitro-1H-imidazole-5-yl)methyl N,N'-bis(2-bromoethyl) diamidophosphate,
16-base single-stranded peptide nucleic acid oligonucleotide linked to a 7-amino acid peptide,
18-(p-(,
4-oxo-4H-chromene-2-carboxylic acid (2-(2-4-(2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl)-phenyl-2H-tetrazol-5-yl)-4,5-dimethoxy-phenyl)-amide,
7-ethyl-10-hydroxy-camptothecin,
Alitretinoin
(
PANRETIN
),
Anlotinib,
Autologous CD4+ and CD8+ T cells transduced with a lentiviral vector encoding an affinity enhanced T cell receptor specific to MAGE-A4,
Autologous CD4+ and CD8+ T cells transduced with lentiviral vector containing an affinity-enhanced T-cell receptor targeting the New York esophageal antigen-1,
Brostallicin,
Camsirubicin,
Crenolanib besylate,
Daunorubicin liposome injection
(
DAUNOXOME
),
Deforolimus,
Doxorubicin hydrochloride (liposomal)
(
DOXIL
),
Doxorubicin(6-maleimidocaproyl)hydrazone,
Fenretinide,
Fibromun,
Genetically modified serotype 5/3 adenovirus coding for granulocyte-macrophage colony-stimulating factor,
Human/murine chimeric monoclonal antibody against endoglin,
Interferon alfa 2a
(
ROFERON A
),
Interferon alpha 2b
(
INTRONA
),
Larotrectinib
(
VITRAKVI
),
Mammalian target of rapamcyin (mTOR) inhibitor,
N-acetylsarcosyl-glycyl-L-valyl-D-allo-isoleucyl-L-threonyl-L-norvalyl-L-isoleucyl-L-arginyl-L-prolyl-N-ethylamide,
Olaratumab
(
LARTRUVO
),
Ombrabulin,
Paclitaxel
(
TAXOL
),
Palifosfamide,
Propranolol hydrochloride
(
HEMANGEOL
),
Sindbis virus envelope pseudotyped lentiviral vector encoding New York oesophageal squamous cell carcinoma-1 protein,
Trabectedin
(
YONDELIS
),
Vinorelbine tartrate,
Yttrium (90Y)-DTPA-radiolabelled chimeric monoclonal antibody against frizzled homologue 10
Registered!
Kaposi sarcoma (KS) is a cancer that develops from the cells that line lymph or blood vessels. It usually appears as tumors on the skin or on mucosal surfaces such as inside the mouth, but tumors can also develop in other parts of the body (including the lymph nodes, lungs, or digestive tract). The abnormal cells of Kaposi sarcoma cause purplish, reddish blue, or dark brown/black skin lesions (macules, nodules, plaques) on the legs and the face. These lesions may look bad, but they usually cause no symptoms. However, when the lesions are in the lungs, liver, or digestive tract, they may cause serious problems like gastrointestinal bleeding or trouble breathing. Kaposi sarcoma is caused by infection with a virus called the Kaposi sarcoma associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8). Kaposi sarcoma is classified into four types based upon the different populations in which it develops: classic (which presents in middle or old age), endemic (described in sub-Saharan indigenous Africans), iatrogenic (associated with immunosuppressive drug therapy) and AIDS-associated (epidemic KS). Options for treatment may include local therapy, radiation therapy, chemotherapy and biologic therapy (immunotherapy). The main aim is to restore immunity.